Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Nicotinic acetylcholine receptor (AChR)"”.
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Structure-function studies of agonist binding to the muscle-type nicotinic acetylcholine receptor and the development of a trifunctional non-competitive antagonist suitable for activity-dependent profiling
The muscle-type nicotinic acetylcholine receptor (AChR) is a ligand-gated ion channel required for fast synaptic transmission at the neuromuscular junction. It is the archetype of the Cys-Loop superfamily of receptors and a prototypic allosteric protein. The muscle-type AChR has two distinct …
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Poly(ethylene glycol)-based open-channel blockers for the acetylcholine receptor : mechanistic and structure-function studies at the single-channel level
… study is presented for the muscle-type nicotinic acetylcholine receptor (AChR). Single-channel electrophysiological measurements with a series of PEG-trimethylammonium (PEG-TMA) conjugates show that short bivalent PEG-TMAs containing four to thirteen ethylene oxide units in the backbone …
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Molecular determinants of conductance and charge-selectivity in pentameric ligand-gated ion channels
… ion channels, that includes (in vertebrates) the nicotinic Acetylcholine Receptor (AChR), Serotonin Receptor type 3 (5-HT3R), γ-Aminobutyric acid Receptor type A (GABAAR), and the Glycine Receptor (GlyR). All of these channels are made up of five subunits. Some pLGICs are homomeric and others are …
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Έκφραση μεταλλαγμένων τμημάτων του νικοτινικού υποδοχέα ακετυλοχολίνης και χρήση τους για την ανάπτυξη θεραπείας για τη μυασθένεια
… του εξωκυτταρικού τμήματος του υποδοχέα, της acetylcholine binding protein (AChBP) από το σαλιγκάρι Lymnaea stagnalis έφερε και τις πρώτες πληροφορίες υψηλής ανάλυσης. Η AChBP είναι μια υδατοδιαλυτή πρωτεΐνη, η οποία σχηματίζει σταθερά ομοπενταμερή, με ομολογία 20%-24% με το εξωκυτταρικό τμήμα …