Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Nicotinic Receptors"”.
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Cytotoxic Alkaloids from Microcos paniculata with Activity at Neuronal Nicotinic Receptors
… alkaloids and certain previously identified nicotinic receptor (nAChR) antagonists, along with growing evidence to support the involvement of nAChRs in various aspects of cancer, provided a rationale to examine the effects of the isolates on nAChRs (Egleton et al., 2008; Schuller, 2009; …
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Regulation of Expression and Function of Neuronal Nicotinic Receptors by Accessory Subunits
Nicotine binds to nicotinic acetylcholine receptors (nAChRs) and perturbs the biogenesis and trafficking of these channels. The α4β2 and α3β4 subtypes are the most abundantly expressed nAChRs in the central and peripheral nervous system, respectively, and are key mediators of nicotine dependence …
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Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα
SPECIFIC AIMS OF THE STUDY 1) To investigate whether FAEs can suppress nicotine-induced stimulation of VTA dopamine (DA) neuron firing rate through the peroxisome-proliferator-activated receptor-α (PPARα) and to elucidate their mechanism of action in an in vitro brain slice preparation. 2) To …
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Role of M3 muscarinic receptor in regulation of immunity to infectious pathogens
… cholinergic signaling via acetylcholine and its receptors has emerged as an important regulator of immunity. Acetylcholine binds to and signals through two types of receptors; nicotinic and muscarinic receptors. Studies have shown that signaling through nicotinic receptors, particularly the α7 …
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ESTUDOS VISANDO A SÍNTESE DE DIAMINAS DERIVADAS DE PINENOS COM POTENCIAIS ATIVIDADES NOS RECEPTORES NICOTÍNICOS DO SISTEMA NERVOSO CENTRAL
… with potential activities as agonists of the nicotinic receptors. All the substances aimed are nicotinic analogous and the parameter of distance between the nitrogens sp2 and sp3 of these molecules was evaluated by molecular modeling in way half-empiricist AM1 method. The ketones 2a,b had been …
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The Influence of Alpha7 and Alpha4 Beta2 Nicotinic Receptor Agonists on Feature Based Reversal Learning in Macaque Monkeys
Selective and non-selective nicotinic agonists are associated with improvements in higher order cognitive functions. However, the effects of selectively activating nicotinic sub-receptors on attention and learning are not well understood. In my project, I used two agonists selective for alpha7 (7) …
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Cholinergic Control of Cortical Circuit Activity
… was reliant on the engagement of both nicotinic and muscarinic acetylcholine receptors. Nicotinic receptors mediated transient suppression by acting in the superficial cortical layers, while muscarinic receptors mediated prolonged suppression in layer 4. In agreement, we found …
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Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ganglia, where it contributes to signal transduction from the central nervous …
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A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… decreases in the binding at muscarinic and nicotinic receptors. MPTP also inhibited acetylcholinesterase (AChE) activity and increased choline levels. The MPTP-induced increase in DA release and the decreases in catecholamines in SH-SYSY cells were blocked by pretreatment with acetylcholine …
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Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of
… carbachol-induced AA is mediated by muscarinic receptors within the pVTA and by both muscarinic and nicotinic receptors within the aVTA. Using the conditioned place preference paradigm (CPP), the present study evaluated the muscarinic versus nicotinic involvement in intra-VTA carbachol-induced …
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The expression of muscarinc acetylcholine receptors on the avian vestibular hair cells and the modulation effects on KIR2.1
… acetylcholine (ACh). Two types of acetylcholine receptors (AChRs) have been suggested to be located on hair cells (HCs). They were nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs). Even though pioneering physiological and pharmacological studies have shown evidence of mAChR located …
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Neuronal plasticity in the enteric nervous system motor pathways
… are not yet known. Acetylcholine acting on nicotinic receptors mediates the majority of fast synaptic transmission between enteric neurons, however, recent studies suggest that the peristaltic motor pattern can occur during nicotinic receptor blockade. The aim of this thesis was to determine …
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EARLY ADOLESCENT NICOTINE EXPOSURE HAS LONG-LASTING EFFECTS ON COCAINE-INDUCED BEHAVIORS IN MICE
… factors, through activation of neuronal nicotinic receptors. We used mice as a model system to investigate the effects of adolescent nicotine exposure on responses to cocaine, amphetamine, and morphine in adulthood. We found that exposure to nicotine during the early phase of adolescence …
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Single-Channel Studies of Agonist Interactions With the Neurotransmitter-Binding and Pore Domains of the Muscle Nicotinic Acetylcholine Receptor
The nicotinic acetylcholine receptor, a ligand-gated ion channel, is activated by a variety of naturally occurring and synthetic ligands. The overall 'response' elicited by any ligand of the nicotinic receptor is not only a consequence of its binding to the extracellular neurotransmitter-binding …
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MODULATION OF SYNAPTIC TRANSMISSION AT THE NUCLEUS TRACTUS SOLITARIUS
… within the NTS, but studies have suggested that nicotinic acetylcholine receptors (nAChRs) and transient receptor potential (TRP) channels can modulate excitatory/inhibitory neurotransmission. I have designed studies to understand the role of nAChRs and TRP channels in the modulation of …
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INVESTIGATING THE ROLE OF α6 and α4 CONTAINING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN NICOTINE AND COCAINE CONDITIONED PLACE PREFERENCE TESTS IN MICE.
<p>Neuronal nicotinic acetylcholine receptors modulate both cholinergic and non-cholinergic synaptic transmission. Our research concerns α6 and α4 neuronal nicotinic subunits because they often co-assemble with the β2 subunit, which has abundant expression in the CNS and previous work has …
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The role of high affinity nicotinic acetylcholine receptors on anxiety-like behavior: a study in female mice
… yet little is known about the contributions of nicotinic acetylcholine receptors (nAChRs) on anxiety-like behavior. β2*nAChRs (*denotes assembly with other subunits) are the most abundantly expressed nAChRs in the brain yet little is known about the contributions of β2*nAChRs on anxiety-like …
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Development and application of quantitative ligand-binding studies to elucidate mechanistic aspects of pentameric ligand-gated ion channels
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-12-01
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Ruolo del peptide β-Amiloide nella sinapsi in condizioni fisiologiche e nella malattia di Alzheimer: interazioni con i recettori a7-nAChRs e i nucleotidi ciclici
La Malattia di Alzheimer (AD) è una patologia neurodegenerativa che rappresenta la più comune forma di demenza nell’anziano. Purtroppo, nonostante decenni di ricerca, la fisiopatologia dell’AD non è ancora stata compresa e non sono disponibili terapie efficaci. L'aumento del peptide …