Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Nicotinic Agonists"”.
-
The Influence of Alpha7 and Alpha4 Beta2 Nicotinic Receptor Agonists on Feature Based Reversal Learning in Macaque Monkeys
Selective and non-selective nicotinic agonists are associated with improvements in higher order cognitive functions. However, the effects of selectively activating nicotinic sub-receptors on attention and learning are not well understood. In my project, I used two agonists selective for alpha7 (7) …
-
Organophosphorus Pesticide Exposure Effects on Neurobehavioral Development of Zebrafish and Characterization of Developmental Switch Between Two Cation-chloride Cotransporters (zfnkcc1 and zfkcc2)
… </p><p>We preliminarily examined how affecting nicotinic signaling with exposures to nicotinic agonists/antagonists can affect the expression of <italic>zfnkcc2</italic> and <italic>zfkcc2</italic>. While there were no apparent changes in the expression pattern from any of the exposures at 2 …
-
Single-Channel Studies of Agonist Interactions With the Neurotransmitter-Binding and Pore Domains of the Muscle Nicotinic Acetylcholine Receptor
The nicotinic acetylcholine receptor, a ligand-gated ion channel, is activated by a variety of naturally occurring and synthetic ligands. The overall 'response' elicited by any ligand of the nicotinic receptor is not only a consequence of its binding to the extracellular neurotransmitter-binding …
-
Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ganglia, where it contributes to signal transduction from the central nervous …
-
DESIGN, SYNTHESIS AND PHARMACOLOGICAL INVESTIGATION OF NOVEL BIFUNCTIONAL COMPOUNDS
… containing D2 autoreceptors and non-alpha7 nicotinic acetylcholine receptors (nAChRs). This evidence encouraged an in-depth investigation of the biochemical and functional interactions between dopaminergic autoreceptors and nAChRs containing the beta2 subunit. Aims - The deliberate, rational …
-
THE MECHANISMS AND PHARMACOLOGY OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN THE CENTRAL NERVOUS SYSTEM
Neuronal nicotinic acetylcholine receptors (nAChRs) are key players in both cognitive and autonomic processes. In the cognitive domains of the brain, destruction of cholinergic inputs or disruption of nAChR function result in cognitive deficits as observed in Alzheimer's disease, schizophrenia, …