Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"Nicotinic Acetylcholine Receptors"”.
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The Characterisation Of Bee Nicotinic Acetylcholine Receptors
… of commercially important insecticides are the nicotinic acetylcholine receptors. In this study we clone the majority of the Apis mellifera nAChR gene family and putative nAChR chaperones in an attempt to functionally characterise the pharmacological effects of these insecticides. Through the …
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Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂
… suggest that the two major CNS cholinergic nicotinic acetylcholine receptor subtypes a4p2 and a7 may interact directly with Ap and therefore, a multidisciplinary approach has been used to evaluate the reported interaction.
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Searching for structural determinants of agonist selectivity in nicotinic acetylcholine receptors
The α4β2 and α7 receptors are the most abundant nicotinic acetylcholine receptors (nAChRs) in the brain, where they contribute to cognition, reward, nociception and mood. They are also implicated in depression, schizophrenia, cognitive deficit and in addiction to nicotine (Nic). Activation of these …
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THE MECHANISMS AND PHARMACOLOGY OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN THE CENTRAL NERVOUS SYSTEM
Neuronal nicotinic acetylcholine receptors (nAChRs) are key players in both cognitive and autonomic processes. In the cognitive domains of the brain, destruction of cholinergic inputs or disruption of nAChR function result in cognitive deficits as observed in Alzheimer's disease, schizophrenia, …
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THREE-FINGER TOXINS AS SELECTIVE PROBES TO DISTINGUISH SUBUNIT INTERFACES OF NICOTINIC ACETYLCHOLINE RECEPTORS
… that selectively antagonize postsynaptic nicotinic acetylcholine receptors (nAChRs). For the first time, the cryo-EM structure of a natural ?-neurotoxin, Erabutoxin-A (Ea), complexed with Tetronarce californica nAChR has been elucidated. From the atomic model, in silico Ea mutants at the …
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Heterologous Expression of Alpha 6*- Nicotinic Acetylcholine Receptors and the Natural Distribution of Alpha 6 Subunits
Nicotinic acetylcholine receptors (nAChR) are neurotransmitter-gated ion channels that exist as a family of subtypes defined by unique subunit compositions. nAChR containing α6 subunits (α6*-nAChR) have attracted interest because α6 subunits are thought to be localized in brain regions implicated …
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The role of high affinity nicotinic acetylcholine receptors on anxiety-like behavior: a study in female mice
… yet little is known about the contributions of nicotinic acetylcholine receptors (nAChRs) on anxiety-like behavior. β2*nAChRs (*denotes assembly with other subunits) are the most abundantly expressed nAChRs in the brain yet little is known about the contributions of β2*nAChRs on anxiety-like …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
Allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs) is considered to be one of the most promising approaches for therapeutics. By binding to a site of the receptor distinct from the neurotransmitter binding site, allosteric modulators alter the response of the receptors to …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
Allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs) is considered to be one of the most promising approaches for therapeutics. By binding to a site of the receptor distinct from the neurotransmitter binding site allosteric modulators alter the response of the receptors to …
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Studies of nicotinic acetylcholine receptors containing α4 and α6 subunits in nicotine-induced synaptic plasticity in brain reward areas
… in tobacco smoke, activates and/or desensitizes nicotinic acetylcholine receptors (nAChRs) throughout the brain. nAChRs in ventral tegmental area (VTA) dopamine (DA) neurons are crucial for the rewarding and reinforcing properties of nicotine. Nicotine causes cellular changes in VTA DA neurons, …
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The emerging role of the a4(+)a4(-) interface as a determinant of functional signatures of a4ß2 nicotinic acetylcholine receptors
The a4~2 nicotinic acetylcholine receptor (nAChR) assembles in two alternate forms, (a4p2ha4 and (a4~2hP2, which display stoichiometry-specific agonist sensitivity. Being heteromeric pentameric ligand-gated ion channels (pLGIC), a4p2 receptors are activated by binding of agonist to sites located at …
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Classification of Neuronal Nicotinic Acetylcholine Receptors in Rat CA1 Hippocampal Interneuron Subpopulations Defined by Calcium-Binding Protein mRNA Expression
… calbindin, calretinin, parvalbumin) and eight nicotinic acetylcholine receptor (nAChR) subunits (alpha2-alpha5, alpha7, beta2-beta4) from interneurons from the stratum radiatum or stratum oriens within the CA1 region of rat hippocampi was analyzed using quantitative real time RT-PCR. …
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INVESTIGATING THE ROLE OF α6 and α4 CONTAINING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN NICOTINE AND COCAINE CONDITIONED PLACE PREFERENCE TESTS IN MICE.
<p>Neuronal nicotinic acetylcholine receptors modulate both cholinergic and non-cholinergic synaptic transmission. Our research concerns α6 and α4 neuronal nicotinic subunits because they often co-assemble with the β2 subunit, which has abundant expression in the CNS and previous work has …
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Engineering and functional characterisation of pentameric concatenated (alpha 4)2 (beta 2)3 and (alpha 4)3 (beta 2)2 nicotinic acetylcholine receptors
Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that influence neurotransmitter release, hence constituting a key component of the physiological mechanisms of neuronal signalling. This thesis is concerned with the properties of the a4P2 nAChR, the most abundant …
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Functional characterisation of aphid, Myzus persicae, nicotinic acetylcholine receptors and identification of a novel biogenic amine-gated ion channel from the honeybee, Apis mellifera
Nicotinic acetylcholine receptors (nAChRs) are cysteine-loop ligand-gated ion channels that are the targets of effective insecticides, including neonicotinoids and spinosad. The heterologous expression of nAChRs, in Xenopus laevis oocytes, has enabled the study of functional and pharmacological …
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Synthesis and Biological Evaluation of Novel Epibatidine Analogues
… an effect to develop for more selective neuronal nicotinic acetylcholine receptor analgesics that have less toxicity and adverse side effects relative to epibatidine, three new classes of epibatidine analogues were synthesized and evaluated in vitro as potential potent selective nAChR ligands. …
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Preclinical Investigations Of Genetic Correlates Of Alcohol Use Disorder
… transporter, (ii) the GluK1-containing kainate receptors, and (iii) the α5-containing nicotinic acetylcholine receptors (nAChR). First, we describe disturbances in baseline behavior and increased volitional alcohol intake in animals lacking the ZIP8 transporter. We then report the effects of …
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Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats
… the effects of mecamylamine, an antagonist to nicotinic acetylcholine receptors, on conditioned hyperactivity and sensitization. This antagonistic drug has been shown to attenuate the locomotor effects of nicotine. In the current study, EC, IC, and social condition (SC) rats were reared from 21 …
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