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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Nicotine Exposure"”.
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THE IMPACT OF ADOLESCENT NICOTINE EXPOSURE ON DRUG DEPENDENCE IN ADULTHOOD
Nicotine is one of the first and most commonly abused drugs in adolescence. According to The Center for Disease Control, every day more than 6000 adolescents try their first cigarette and over 3000 of them become daily smokers. Smoking among adolescents is a strong predictor of future drug abuse …
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Plasticity of Brainstem Motor Systems in Response to Developmental Nicotine Exposure
Developmental nicotine exposure (DNE) is known to cause abnormal development of multiple brain regions and results in impaired control of breathing and altered behaviors that rely on proper coordination of the muscles of the tongue. The adverse effects of nicotine are presumably caused by its …
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Perinatal Nicotine Exposure and Programming of HIE Sensitive Phenotype in Neonatal Rat Brains
… study aims to test the hypothesis that perinatal nicotine exposure induces reprogramming of susceptibility to hypoxic ischemic brain injury in the immature brain, focusing on the roles of AT1R and/or AT2R and trying to reveal the underlying epigenetic mechanisms. Therefore, we established two rat …
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EARLY ADOLESCENT NICOTINE EXPOSURE HAS LONG-LASTING EFFECTS ON COCAINE-INDUCED BEHAVIORS IN MICE
<p>Nicotine is one of the most commonly used drugs among adolescent populations. Given the fact that adolescence is a unique developmental stage, during which nicotine has long-term effects on future drug-taking behavior, it is essential to understand how early exposure to nicotine during …
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The influence of maternal nicotine exposure on development lung as gas exchanger: the protective effect of copper
… the developing fetus is well reported. Maternal nicotine exposure during pregnancy and lactation interferes with fetal and neonatal lung growth and development, rendering the lungs more susceptible to damage and disease. interference with the normal developmental processes at any stage may …
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Developmental Nicotine Exposure And Its Effects On Morphology And Electrophysiology Of Hypoglossal Motoneurons In The Neonatal Rat
Developmental nicotine exposure (DNE) is known to cause deleterious effects in neonatal mammals through nicotine's actions on nicotinic acetylcholine receptors (nAChRs). In this work, we studied how DNE altered the structure and function of the hypoglossal motoneurons (XIIMNs) over the first few …
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Premature aging of the lungs of the offspring induced by maternal nicotine exposure during gestation and lactation: protective effects of tomato juice
… The offspring is as a result exposed to nicotine through the blood and the milk of the mother. Nicotine is thus expected to interact with the developing fetus and the offspring of mothers who smoke or use NRT for smoking cessation, resulting in the interference with normal fetal and …
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Prenatal Intravenous Nicotine Exposure: Increased Motivation For Methamphetamine Self-Administration, Altered Methamphetamine-Induced Locomotor Activity and Brain-Derived Neurotrophic Factor Protein Levels In Adult Rats
… the experiment investigated the impact of US-preexposures on METH-induced CTA, in periadolescent (PND 30 - 40) and young adult (PND 60 - 70) rats with two preexposure-to-conditioning delays; either 3 or 9 days. </p> <p> Animals were preexposed for 5 consecutive days to METH (1.0 mg/kg), prior to …
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Does maternal nicotine exposure during gestation and lactation change the oxidant-antioxidant status of the lungs of the offsprings and is tomato juice protecting the lungs of the offsprings?
Nicotine exposure to the fetus through tobacco smoking or nicotine replacement therapy during the whole period of gestation and lactation causes diverse effects on fetal and neonatal lung development, integrity and maturation which compromise the gas exchange function of the lungs and renders this …
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Nicotine Alters Gene Regulatory Networks in Dopaminergic Neurons in the Ventral Tegmental Area
… abuse later in life. Studies have shown that nicotine, the primary addictive and psychoactive component of tobacco, modulates gene expression in many brain regions implicated in the reward pathway. Dopaminergic (DA) neurons originating from the ventral tegmental area (VTA) of the brain are …
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An investigation into the effect of maternal exposure to nicotine and copper on neonatal lung development
… smoke, despite awareness of the implications of exposure for themselves and those around them. Campaigns for the promotion of effective tobacco legislation and awareness are continuously being confronted by the tobacco industry’s reluctance to put the health of their consumers before company …
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Three Generations, One Future: A Systematic Analysis on Nicotine's Effect across generations in C. elegans.
… tobacco-smoke related negative consequences is nicotine. Nicotine is an addictive poison that entraps users in a vicious cycle of constant drug seeking and reinforcement. Despite the public health policies and laws enforced to decrease the habitual smoking, it is still prevalent, especially …
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Obstructive Lung Disease among tobacco farmers in Malawi
… are exposed to toxic workplace hazards such as nicotine and pesticides in addition to known agriculture related hazards like dust, and ergonomic factors. Nicotine and pesticide exposure have been linked to the development of chronic respiratory diseases. This study was aimed at determining the …
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Strain-dependent and age-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.
… in both humans and animals demonstrates that nicotine addiction is a complex disorder that can be influenced by several factors. For instance, individual differences in genetics can impact sensitivity to nicotine and can modulate the severity of nicotine withdrawal. Although nicotine alters …
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The Effects of Ethanol and Nicotine on Hepatic and Brain CYP2 Family Enzymes in African Green Monkeys
… independent and combined effects of ethanol and nicotine on hepatic and/or brain levels of CYP2E1, CYP2B6 and CYP2A6 in African green monkeys. Monkeys were randomized into four groups (N = 10/group): an ethanol-only group, a nicotine-only group, an ethanol + nicotine group and a control (no drug) …
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Auswirkungen der in-utero-Nikotinexposition auf kardiorespiratorische Phänomene während des ersten Lebensjahres : polysomnographische Vergleichstudie einer Referenzgruppe mit einer Studiengruppe mittels linearer und logistischer Regressionen
… incidence of cot death and the previous in utero nicotine exposure of the fetus. To date, few studies have examined their effects on cardio-respiratory phenomena in infants. Our retrospective study compares 37 polysomnography of 32 children (16 m/16 f) of a study group of 86 children with 95 …
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NICOTINE AND METHYLPHENIDATE CHORNIC EXPOSURE ON ADULT CANNABINOID RECEPTOR AGONIST (CP 55,940) PLACE CONDITIONING IN MALE RATS
… has been reported between those who use nicotine related products alone or in combination with ADHD medications, like methylphenidate (MPH), in late childhood or early adolescence and the increased likelihood of later marijuana abuse in adulthood. Pre-clinical studies have found that the …
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Pharmacological studies of C. elegans cultured in axenic media: nicotine and its effects on growth, body morphology, and reproduction
… phenotypic effects brought about by teratogenic nicotine exposure at various concentrations. This was used as a proof of concept that axenic media can be used as an alternative for pharmaceutical assays on C. elegans and that the baseline data acquired for CeHR will enable more laboratories to …
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Intracellular Signaling Contributions to Behaviors Relevant to Nicotine Addiction
Nicotine is the primary addictive substance in tobacco, and most smokers who quit will relapse within a year. Evidence shows that cigarette craving increases over time, termed “incubation.” The purpose of these studies was to see if protracted abstinence from chronic nicotine increases rat …
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E-Cigarettes: Biomarkers of Exposure and the Development and Validation of a Research Toolkit
Electronic nicotine delivery systems (ENDS) have gained worldwide popularity. Even so, there is limited research on the potential effects of regular ENDS use on health. Moreover, little is known about ENDS dependence and studies are often limited by a lack of validated research tools. Current …
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