Global ETD Search
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Showing 1 to 7 of 7 for “"Nicotinamide adenine dinucleotide phosphate (NADPH)"”.
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The impact of NOX4 deficiency on sexually dimorphic lipid handling in HFD-challenged mice
… of proteins that regulate nutrient metabolism. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is a dynamic, pleiotropic enzyme that generates ROS in response to nutrient levels. Here we demonstrate, particularly in the liver, skeletal muscle, and bone marrow, that in …
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Metabolic Regulation of Cellular Signaling
… of cell death. We found that glucose-6-phosphate (G6P) via the pentose phosphate pathway leads to increased nicotinamide adenine dinucleotide phosphate (NADPH) levels, a subsequent increase in cytosolic acetyl-coenzyme A and activation of Ca2+/calmodulin-dependent protein kinase II …
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Toward Quantitative Understanding of Compartmentalized NADPH Metabolism in Cancer Cells
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential molecule in living organisms by virtue of its function as electron donor driving reductive biosynthesis and protecting cells against oxidative stress. Over the past decades, extensive research has studied key NADPH …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… enzymes that associate with flavin adenine dinucleotide (FAD) and use the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH) in oxidationreduction (Redox) reactions. Although MICALs have no known substrate/s, my in vivo and in vitro results revealed that Mical employs its …
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Direct Redox Regulation of F-Actin Assembly and Disassembly by MICAL
… enzymes that associate with flavin adenine dinucleotide (FAD) and use the co-enzyme nicotinamide adenine dinucleotide phosphate (NADPH) in oxidationreduction (Redox) reactions. Although MICALs have no known substrate/s, my in vivo and in vitro results revealed that Mical employs its …
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Towards next-generation enzymatic generators of hydrogen peroxide in quantitative redox biology
… to cell culture or stimulation and inhibition of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. However, these methodologies add conflating variables of extracellular H₂O₂, a gradient between extracellular and intracellular species, and production of superoxide (02-) as an …
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Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways
… of Erk1/2 activation in LSMCs and MSMCs; 4) NADPH oxidase components are expressed in leiomyoma and normal myometrial tissue; 5) PDGF induces translocation of p47phox into lipid rafts in LSMCs; 6) PKC mediates Erk1/2 activation by PDGF in MSMCs and LSMCs; 7) PKC activation alone is sufficient …