Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Nicotinamide Riboside (NR)"”.
-
Nicotinamide Riboside Delivery Generates NAD+ Reserves to Protect Vascular Cells Against Oxidative Damage
… do not exist. This study determines if nicotinamide riboside (NR) delivery can augment NAD+ stores and fuel resistance to oxidative stress. I established that oxidative-stress insult on vascular cells decreased NAD+ levels, accompanied by a striking increase in nuclear PAR-chain …
-
Mitochondrial protein acetylation and left ventricular function in a model of hypertrophic cardiomyopathy and heart failure
… were treated with NAD+ replacement therapy with nicotinamide riboside (NR), and FXN/SIRT3 DKO mice were treated with FXN protein replacement therapy. Results: Acetylation was temporally progressive and paralleled evolution of heart failure in the FXN KO model. High levels of acetylation were …
-
Mutational and Structural Investigation of SARM1, a Protein that Mediates Axon Loss
… and/or WT after removing NAD precursor nicotinamide riboside (NR) or addition of Vacor, which normally leads to SARM1 activation. All artificial mutants in the SARM1 ARM domain allosteric site influence NAD levels in transfected HEK293T cells and alter basal and/or induced SARM1 NADase …
-
Chronic activation and downstream mechanisms of programmed axon death
… and hyperactive SARM1 variants found to be enriched in patients with motor nerve disorders. While the pathway’s role in axon degeneration caused by acute insults has been well characterised, the emerging clinical data highlight the need to study the contribution of programmed axon death to …
-
Targeting Metabolic Alterations Associated With Smooth Muscle Α-Actin Pathogenic Variant Attenuates Moyamoya-Like Cerebrovascular Disease
… decreased electron transport chain activity. Nicotinamide riboside (NR), a NAD+ analogue, altered this metabolic profile. NR decreased glycolysis and increased OXPHOS by enhancing complex I activity without altering mitochondrial mass in <em>Acta2</em><sup>SMC-R179C/+</sup> SMCs. Furthermore, …
-
Genotype and phenotype in mitochondrial disorders
… treatment is to induce mitochondrial biogenesis. Nicotinamide Riboside (NR) is an NAD+ booster which showed promising results in two mouse models of mitochondrial disorders. We describe an open label study to test the effect of NR for four weeks in eight individuals with m.3243A>G, m.3243A>T or …
-
Chronic Gestational Inflammation: Comparisons of Obesity-Mediated and Preeclampsia-Mediated Placental Inflammation using Transcriptomic and Histological Methods
… analysis using DESeq2. Ranked gene set enrichment was conducted using fold change values through GO Annotation Database. Similarly, pathway enrichment was performed through KEGG database (FDR <= 0.10). Fetal growth restriction was observed in both chronic gestational inflammation models. …