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Showing 1 to 20 of 21 for “"Nicotinamide Adenine Dinucleotide (NAD+)"”.

  1. Novel derivatives of nicotinamide adenine dinucleotide (NAD) and their biological evaluation against NAD-consuming enzymes

    Pergolizzi, GiuliaUniversity of East Anglia2012

    Nicotinamide adenine dinucleotide (β-NAD+) is a primary metabolite involved in fundamental biological processes. Its molecular structure with characteristic functional groups, such as the quaternary nitrogen of the nicotinamide ring, and the two high-energy pyrophosphate and nicotinamide …

    east-anglia Repository record

  2. Investigating the Role of PARylation in Regulating Skeletal Muscle Mass and Function in Healthy Mature Mice

    Pandey, DheerajUniversité d'Ottawa / University of Ottawa2023

    … dependent on the transfer of ADPr units from nicotinamide adenine dinucleotide (NAD+) on to a plethora of biomolecules (i.e., proteins, DNA, RNA, etc.) in response to physiological stressors (i.e., nutrient deprivation, oxidative stress, DNA strand breaks). Poly-ADP-ribosylation (PARylation) …

    ottawa-retro Repository record

  3. A study of succinic dehydrogenase, indole acetic acid oxidase, nitrate reductase and cytochrome c reductase in Hygrophorus Conicus

    Mehta, Jagdish M.University of Missouri--Rolla2016

    … blue, the former was found to be the best. Nicotinamide adenine dinucleotide (NAD⁺) was a necessary cofactor for the enzyme and could be readily dissociated from the enzyme. The enzyme has the properties of a high molecular weight nucleo- or lipoprotein.</p> <p>The presence of two kinds of …

    must-thes Repository record

  4. The role of NAD+ compartmentation and dynamics in Arabidopsis thaliana

    Araujo, Elias FeitosaUniversidade Federal de Viçosa2020

    Nicotinamide adenine dinucleotide (NAD+) is a fundamental coenzyme required to regulate plant central metabolism and redox status homeostasis. Plants produce NAD+ via de novo and salvage pathways. Despite early steps of the two pathways occur in different subcellular compartments, de novo in …

    brazil-ufv Repository record

  5. Properties of NadV / NatV Proteins in a Pyridine Nucleotide (NAD+) Scavenging System Encoded by Vibriophage KVP40

    Li, Zhiqun2004

    … kbp dsDNA genome, a set of bacterial-like genes, nadV, natV, pnuC, nadR and sir2 are predicted to be involved in the synthesis and recycling of nicotinamide adenine dinucleotide (NAD+). Comparison with proteins of known function indicates that NadV possesses a nicotinamide …

    ncsu Repository record

  6. Modulation of Transcription Factor Chromatin Association and Gene Transcription Program in Embryonic Stem Cell and Triple Negative Breast Cancer by Poly (ADP-Ribose) Polymerase 1

    Liu, ZiyingUT Southwestern Medical Center2016

    … the transfer of ADP-ribose (ADPR) units from nicotinamide adenine dinucleotide (NAD+) onto target gene regulatory proteins, thereby modulating their activities. Although great strides have been made in the past decade in deciphering the seemingly opposing and varied roles of PARP-1 in gene …

    utswmed Repository record

  7. Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer

    Coleman, MichaelUniversity College Cork2017

    … We implicated disruption of the activity of the Nicotinamide adenine dinucleotide (NAD+) dependent deacetylase Sirtuin 1 (SIRT1) in this impairment of mitophagy/autophagy. Crucially we observed strong support for these key findings in human cancer, where PNC1 expression is inversely correlated …

    cork Repository record

  8. NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer

    Bowlby, Sarah ChamberlainWake Forest University2012

    Traditionally, nicotinamide adenine dinucleotide (NAD<super>+</super>) is recognized as a redox cofactor which participates in numerous metabolic reactions. However, new evidence shows that many enzymes consume NAD+ as a substrate to regulate activities from posttranslational modifications to DNA …

    wfu Repository record

  9. Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis

    Ryu, Keun Woo2020

    … transcriptional outcome is poorly understood. Nicotinamide adenine dinucleotide (NAD+) is an essential small molecule co-factor in metabolic redox reactions as well as a substrate for many NAD+-dependent enzymes, such as poly(ADP-ribose) polymerases (PARPs; e.g., PARP-1) or sirtuins (SIRTs; …

    utswmed Repository record

  10. Bio-Nano Interfaces: Enzyme Immobilization for Biomimetic Energy Harvesting

    Hjelm, Rachel2018

    … overpotential through regeneration of oxidized nicotinamide adenine dinucleotide (NAD+) from reduced form (NADH).'</p>

    unm Repository record

  11. Nampt-Mediated Nad+ Homeostasis in Skeletal Muscle: Implications for Healthy Aging

    Frederick, David2016

    … the fundamental electron-shuttling metabolite, nicotinamide adenine dinucleotide (NAD), as a co-factor and signaling intermediate uniquely positioned to modulate whole-body energy balance through transcriptional and post-translational mechanisms. Though it has long been known that NAD supports …

    penn Repository record

  12. USING CHEMICAL AND PROTEOMICS APPROACHES TO STUDY THE FUNCTIONS OF SIRT6 AND KRAS

    Zhang, XiaoyuCornell University2017

    … regulator 2) family of enzymes (or sirtuins) are nicotinamide adenine dinucleotide (NAD+)-dependent protein lysine deacylases and play a variety of roles in biological systems. SIRT6 is one of the seven mammalian sirtuins and has diverse biological functions such as maintaining genomic stability, …

    cornell Repository record

  13. Reactive Oxygen Species-Induced Necrotic Cell Death

    Xie, RuiyuThe University of Arizona.2009

    … hyperactivation of PARP-1, rapid depletion of nicotinamide adenine dinucleotide (NAD), elevations in intracellular Ca2+ concentrations, loss of mitochondrial membrane potential, and subsequent necrotic cell death. Interestingly, PARP-1 hyperactivation was not accompanied by the translocation of …

    arizona-thes Repository record

  14. Coenzyme engineering of NAD(P)+ dependent dehydrogenases

    Huang, RuiVirginia Tech2017

    Coenzyme nicotinamide adenine dinucleotide (NAD, including the oxidized form-- NAD+ and reduced form--NADH) and the phosphorylated form--nicotinamide adenine dinucleotide phosphate (NADP, including NADP+ and NADPH) are two of the most important biological electron carriers. Most NAD(P) dependent …

    vt Repository record

  15. A Role for PI31-Mediated Proteasome Regulation in Proteostasis and Neuronal Health

    Jones, Sandra

    … how proteasomes are regulated by changes in nicotinamide adenine dinucleotide (NAD+) metabolism and how this impacts neurodegeneration. Using Drosophila melanogaster, I describe the necessity for the proteasome regulator, DmPI31, in neuronal maintenance and show that dietary restriction and …

    rockefeller Repository record

  16. The Physiological Effects of CD38 in Prostate Cancer: A multifunctional NAD'ase capable of regulating cell metabolism, gene expression, and therapeutic response

    Chmielewski, Jeffrey PWake Forest University2018

    … sustain membrane biogenesis, and cell survival. Nicotinamide adenine dinucleotide (NAD+) is linked all aspects of cell metabolism though its ability to act as both an oxidizing and reducing agent for hydride transfer reactions. Proper regulation of NAD+ is also vital to cells as it also serves as …

    wfu Repository record

  17. Protective effect of Nicotinamide on High glucose (HG)/Palmitate (PA)-induced Glucolipotoxicity to INS-1 beta cells

    이, 수진2013

    … and beta cell death in type 2 diabetes. Nicotinamide, via its major metabolite NAD+, is involved in a wide range of biological processes, including the production of energy. Nicotinamide (NAM) significantly protected the cells against the HG/PA-induced cell death. The aim of this study is …

    ajou Repository record

  18. Molecular Effects of the Nampt Inhibitor FK866 on Leukemia Cells

    Zucal, ChiaraUniversità degli studi di Trento2016

    … A critical factor in cellular metabolism is nicotinamide adenine dinucleotide (NAD+) and cancer cells highly rely on it to face increased metabolic demands and proliferation rates. Intracellular NAD+ is a key metabolite involved in several cellular processes, acting either as a coenzyme in …

    trento Repository record

  19. Integrative multiomic insights into Alzheimer’s disease pathology

    Yu, YizhouUniversity of Cambridge2023

    … expressing human Aβ and uncovered alterations in nicotinamide adenine dinucleotide (NAD<sup>+</sup>) metabolism. NAD<sup>+</sup>, a component of vitamin B, is essential for both mitochondrial bioenergetics and DNA repair through NAD<sup>+</sup>-consuming poly (ADP-ribose) polymerases (PARPs). I …

    cambridge Repository record

  20. Quinoline-triazole half-sandwich iridium(III) complexes: Synthesis, antiplasmodial activity and preliminary transfer hydrogenation studies

    Melis, DianaDepartment of Chemistry2020

    … facilitate transfer hydrogenation, by reducing β-nicotinamide adenine dinucleotide (NAD+) to NADH in the presence of hydrogen source, sodium formate. Through preliminary qualitative and quantitative cell-free experiments, it was found that the two most active neutral, cyclometallated complexes …

    cape-town Repository record

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