Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Niclosamide"”.
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Structure-activity relationships of niclosamide to overcome colistin resistance
… existing drugs, such as the anthelmintic niclosamide, known to enhance colistin activity in combination therapy. Despite its potential, niclosamide faces limitations due to poor solubility, bioavailability, and off-target toxicity. Thus, repurposing it as an antibacterial agent …
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INTEGRATION OF QUANTUM-MECHANICAL AND MOLECULAR DOCKING APPROACHES IN GLOBAL METHODS FOR METABOLISM PREDICTION OF XENOBIOTICS
… and uncoupling/inhibitory activity of two niclosamide-derivatives datasets were correlated with molecular descriptors related to the proton shuttle mechanism to further advance the chemical synthesis of niclosamide-based compounds in collaboration with experimental groups.
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A next generation theranostic nano-platform for sustained and enhanced inhibition of cancer stem cells
… unprecedented significance in modern medicine. Niclosamide (Nic), an FDA approved anthelmintic drug, has recently been reported as potent inhibitor of STAT3 and it is seen toand triggered the activation of cancer cell apoptotic mechanism. Despite its promising cancer treatment capabilities, lack …
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Remote Clinical trials Operations: Supply Chain Management and Framework Development
… 2b a clinical trial testing the effectiveness of niclosamide in the shortening the Covid-19 contagious period in children and adolescents and (2) a data collection trial with participants suffering from Long Covid symptoms. Although clinical trials can have different parameters and processes, this …
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Targeting phosphatidylserine exposure in pro-coagulant platelets.
… and CRP-XL or A23187 activation. Abamectin and niclosamide treatment caused a modest reduction in the percentage of platelets that exposed PS in response to thrombin and CRP-XL but this inhibition was attributed to off target effects. Additional experiments in human red blood cells also …
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Identifying novel drugs for the treatment of rhabdomyosarcoma
… were identified by z-scores and amongst these, niclosamide, piroctone olamine and pyrvinium pamoate were validated to be potent inhibitors of TBX2/3 and were shown to display anti-cancer activity in RMS. These drugs have the potential to be repurposed for the treatment of RMS and other TBX2/3 …