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Showing 1 to 2 of 2 for “"NiRAN domain"”.
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Structural and Functional Studies of the SARS-CoV-2 NiRAN Domain
… RdRp-associated nucleotidyltransferase (NiRAN) domain is essential for viral propagation, with three distinct activities associated with modification of the nsp9 N terminus, NMPylation, RNAylation, and deRNAylation/capping via a GDP-polyribonucleotidyltransferase reaction. The latter two …
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Biochemical and Structural Characterization of Divergent Members of the Protein Kinase Family
… kinase family: SidJ-catalyzed Glutamylation, and NiRAN-catalyzed RNA capping. A Legionella pneumophila effector SidJ adopts a kinase fold yet catalyzes calmodulin (CaM)-dependent glutamylation to inactivate the SidE ubiquitin ligases. SidJ becomes activated upon translocation into the host cell …