Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Nhlh2"”.
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Transcriptional and Post-transcriptional Control of Nhlh2 with Differing Energy Status
Nescient Helix Loop Helix 2 (Nhlh2) is a member of the basic helix-loop-helix transcription factor family. Mice with a targeted deletion of Nhlh2, called N2KO mice, show adult onset obesity in both males and females. Nhlh2 regulates other genes by binding to the E-box in the promoter region of …
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The Role of the Nhlh2 Protein in Regulating Male Fertility and Sexual Development
… in men. The nescient helix-loop-helix 2 (NHLH2) transcription factor is expressed in the hypothalamic-pituitary-gonadal axis (HPG), which controls the development of primary and secondary sex characteristics. Signaling from the pituitary reaches the Leydig cells of the testis, which in …
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Transcriptional Regulation of Melanocortin 4 Receptor by Nescient Helix-Loop-Helix-2 and its Implications in Peripheral Energy Homeostasis
… factor Nescient Helix Loop Helix 2 (Nhlh2), is known to influence the melanocortin pathway. It regulates the transcription of genes by binding to the E-Box binding sites present in the promoter region. Here in this dissertation, Nhlh2's role as a transcriptional regulator of Mc4r and …
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Non-coding RNA genes lost in Prader-Willi Syndrome stabilize target RNAs
… the SNORD116 gene is implicated in regulation of NHLH2, a transcription factor gene which plays a key role in development, hormonal regulation, and body weight. In this study we identify phylogenetically conserved regions of SNORD116 and predict interactions with its potential downstream RNA …
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Hypothalamic Transcriptional Profiling and Quantitative Proteomics of Mice under 24-Hour Fasting
Energy balance includes energy intake and energy expenditure. Either excessive food intake or insufficient physical activity will increase the body mass and cause obesity, a worldwide health problem. In the US, more than two-thirds of people are obesity or overweight. Conversely, it is well …