Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Nf2/Merlin"”.
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Hyperactive Rac1 Drives MAPK-Independent Proliferation in Melanoma by Assembly of a Mechanosensitive Dendritic Actin Network
… results in the inactivation of tumor suppressor NF2/Merlin. These data suggest an alternative mechanism for mechanosensitive growth regulation that can be hijacked by cancer cells to circumvent the adverse conditions of foreign microenvironments or drug treatment.
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UNRAVELLING MECHANISMSOF SCHWANN CELLS IN VESTIBULAR SCHWANNOMA AND THEIR IMPACT ON HEARING LOSS.
… the cerebellopontine angle. Although the loss of NF2/merlin is a well-established driver of schwannoma (SCH) formation, likely of the VS, the early biological events that promote SC transformation and the mechanisms underlying VS-associated sensorineural hearing loss (SNHL) remain largely …
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New roles for Hox and Wnt in Cell Migration
… of the C. elegans Neurofibromatosis Type II(NF2)/Merlin homolog nfm-1 is detailed in chapter IV. Previously in the Lundquist lab an unbiased forward genetic screen identified an allele of nfm-1 is required for Q descendant migration. I show that nfm-1 promotes migration of QR and QL lineages …
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Preliminary Study on How Tumor Suppressor Nf2 Inhibits Transcriptional Coactivators Yap/Taz in the Developing Mouse Brain
… the tumor suppressor neurofibromatosis 2 (Nf2) was shown to regulate the balance of neural progenitor proliferation and differentiation in the developing mouse brain through the Hippo pathway effectors, transcriptional coactivators Yap/Taz. The molecular mechanism of how Nf2 regulates …