Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Nf2"”.
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Targeting Aldehyde Dehydrogenases in NF2-null Meningioma and Schwannoma
… driven by loss or mutation of the gene NF2, which encodes the tumour suppressor protein Merlin. Dysregulated Hippo pathway signalling, caused by NF2 loss, drives overexpression of aldehyde dehydrogenase 1A1 (ALDH1A1) in NF2-null schwannoma. High expression of ALDH1A1, and the related …
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Analysis of the function of the Nf2 tumor suppressor protein, Merlin
… Neurofibromatosis type 2 tumor suppressor gene (NF2) is mutated in inherited and sporadically occurring central nervous system tumors. The NF2 encoded protein, merlin, shares close sequence similarity in its amino-terminal domain to members of the band 4.1 family of membrane-cytoskeletal linkers. …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… therapeutic options. Neurofibromatosis Type 2 (NF2) is one of the most commonly inactivated tumor suppressor genes in mesothelioma. The downstream signaling pathways that may be disrupted as a result of this inactivation are not entirely understood. Conversely, the tumor suppressor gene that is …
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The role of the tumor suppressor gene, NF2, in the development of malignant mesothelioma
… therapeutic options. Neurofibromatosis Type 2 (NF2) is one of the most commonly inactivated tumor suppressor genes in mesothelioma. The downstream signaling pathways that may be disrupted as a result of this inactivation are not entirely understood. Conversely, the tumor suppressor gene that is …
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NEUROFIBROMATOSIS TYPE 2 PROTEIN (NF2) AS A REGULATOR OF TUMOR SUPPRESSORS AND VIRAL ONCOPROTEINS IN HUMAN GLIOBLASTOMA
… their specific tumor suppressor genes, NF1 and NF2, respectively. Inactivation of the NF2 gene, results in the development of several multiple benign nervous system tumors. Traditionally, NF2 is viewed as a scaffolding protein primarily located at the plasma membrane, where it prevents excessive …
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Preliminary Study on How Tumor Suppressor Nf2 Inhibits Transcriptional Coactivators Yap/Taz in the Developing Mouse Brain
… the tumor suppressor neurofibromatosis 2 (Nf2) was shown to regulate the balance of neural progenitor proliferation and differentiation in the developing mouse brain through the Hippo pathway effectors, transcriptional coactivators Yap/Taz. The molecular mechanism of how Nf2 regulates …
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… tumors is surgery. Neurofibromatosis type 2 (NF2) is an autosomal dominant inherited cancer predisposition syndrome, caused by a germline mutation in the NF2 tumor suppressor gene, in which affected individuals develop spinal cord (SC) ependymomas. In this dissertation, we use NF2 as a …
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Exploring the Potential use of TEAD Inhibition as Part of a Combination Therapy for NF2-Deficient Schwannoma and Meningioma.
NF2-related Schwannomatosis is a genetic cancer predisposition syndrome, resulting in the development of schwannoma, meningioma and ependymoma tumours. Although surgical resection and adjuvant radiotherapy can be used, new avenues of therapeutic development are essential to target inoperable and …
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Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours
… causes life-altering symptoms. Individuals with NF2-related schwannomatosis may develop schwannomas and meningiomas, increasing tumour burden. The primary treatment for large or symptomatic schwannomas and meningiomas is surgical resection, which may not be suitable in cases involving tumours …
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Outcomes of Auditory Brainstem Implantation in Adults with Postlingual Deafness: A Systematic Review
… and to compare outcomes of ABIs in adults with NF2/tumors to adults without NF2.<strong> </strong></p> <p><strong>Methods: </strong>A comprehensive search utilizing various peer reviewed databases via the City University of New York (CUNY) Graduate Center Library was conducted to identify …
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STUDY OF PHYSIO-PATHOLOGICAL MECHANISMS AT THE BASE OF SCHWANNOMA DEVELOPMENT
… are associated with neurofibromatosis type 2 (NF2), schwannomatosis (SCH) or the pathology called Carney's complex. The schwannoma affecting the auditory nerve, called vestibular schwannoma (VS), is the most common benign tumor of the cerebellopontine angle. The occurrence of VSs is frequent …
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Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
Neurofibromatosis type 2 (NF2) is an autosomal dominant inherited condition that predisposes individuals to develop multiple nervous system tumours, primarily schwannoma, meningioma and ependymoma. NF2 is characterised by loss of the tumour suppressor protein Merlin, caused by bi-allelic mutations …
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The Role of Cellular Prion Protein in the Development of Schwannomas and other Merlin-Deficient Tumours
Neurofibromatosis type 2 (NF2) is an inherited, multiple tumour disease caused by loss of the tumour suppressor protein, Merlin. There are several tumours associated with NF2 including; ependymomas, meningiomas and schwannomas. Merlin loss can also occur sporadically in all of these tumours and is …
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The added value of BAP1 immunohistochemistry and fluorescence in situ hybridisation for CDKN2A/p16 and NF2 in the diagnosis and prognostication of pleural mesothelioma
Background: Mesothelioma is a rare but aggressive malignancy with therapeutic options that are generally palliative. The malignancy can be challenging to diagnose, commonly due to scant samples, often requiring patients to undergo multiple procedures before a definitive diagnosis can be reached. In …
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Investigating the role of TAM (TYRO3, AXL and MERTK) family receptors in merlin deficient tumours
Mutations in the NF2 gene, which codes for the tumour suppressor Merlin, is responsible for the development of all Neurofibromatosis Type 2 (NF2)-related tumours including schwannomas, meningiomas and ependymomas. These tumours can also occur spontaneously in non-NF2 patients. The only available …
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Analysis of Hippo pathway signalling in schwannoma and meningioma
… and meningiomas display the inactivation of the NF2 gene. The NF2 gene codes for the tumour suppressor protein Merlin and its loss is associated with a multitude of pro-tumourigenic mechanisms leading to the occurrence of schwannomas and meningiomas. The loss of Merlin function causes augmented …
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Proteomic analysis of genetically stratified grade-I meningioma
… defined, including in addition to most common NF2 loss, mutations of TRAF7, KLF4, and AKT1. The aim of this study is to identify novel biomarkers and therapeutic targets of genetically stratified meningioma by characterising the proteomic landscape. Materials and methods: Frozen meningioma …
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Characterization of the two major merlin isoforms and merlin regulation of YAP
… the protein encoded by the tumor suppressor gene NF2. Deletion or loss-of-function of NF2 leads to neurofibromatosis type 2, a disease characterized by the formation of multiple benign tumors of the nervous system. In addition to the genetic disorder, loss of merlin expression has been found in …
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Nanocápsulas furtivas de óleo de copaíba contendo anfotericina B: um sistema promissor no tratamento de infecções fúngicas sistêmicas
… other containing low molecular weight chitosan (NF2). NF1 had a particle mean size of 255.1 ± 1.1 nm, polydispersity index (PdI) of 0.144 ± 0.020 and zeta potential of - 27.6 ± 0.15 mV. NF2 system had a particle mean size of 342.6 ± 4.5 nm, PdI of 0.162 ± 0.022 and zeta potential of + 20.2 ± 0.68 …
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Endogenous retroviral proteins as potential drug targets for merlin-deficient tumours
… a hereditary disease Neurofibromatosis type 2 (NF2) characterised by the development of multiple tumours of the nervous system such as schwannomas, meningiomas and ependymomas. Current surgical treatments and radiotherapy for this group of tumours are not fully effective and there is an urgent …
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