Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Next generation impactor"”.
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Development and Evaluation of a Small Volume Liquid Impaction Surface (SVLIS) in the Next Generation Impactor (NGI)
… Volume Liquid Impaction Surface (SVLIS) in the Next Generation Impactor (NGI), a cascade impactor for evaluation of aerodynamic particle size distribution. This SVLIS modified NGI allowed for incorporation of lung cell cultures or drug dissolution of orally inhaled powders following …
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Modification of the Next Generation Impactor and Incorporation of Bacterial Cultures as an In Vitro Pneumonia Model
… impaction surfaces (LVLIS) incorporated into the Next Generation Impactor (NGI). This model allowed for the correlation of deposition and aerodynamic parameters of an antibiotic solution and antibacterial effects. Amberlite® beads were incorporated into the model to absorb the antibiotic so that …
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Investigation to Identify the Influence of the Surface Energetics of the Dry Powder Formulations of Budesonide and Theophylline on Their Aerodynamic Dose Emission Characteristics.
… to their lung deposition performance using a Next Generation Impactor established a relationship between the two. A 1:10 mixing ratio of budesonide with either carrier was found to have the highest FPF. Coating the carriers with 0.05% sodium lauryl sulphate resulted in a further increase in …
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Characterisation of Aerosols Generated by Pressurised Metered Dose Inhalers
… measurements and laser techniques.<br/>The next generation impactor (NGI) experiments revealed the importance of actu-ation forces on the throat deposition. Automated actuation forces with high valve opening rates led to a lower throat deposition than a manual actuation force with low valve …
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DRY POWDER INHALATION OF PNEUMOCOCCAL VACCINE USING POLYMERIC NANOPARTICLES AS CARRIERS
… of anionic NPs/NCMPs determined using a Next Generation Impactor displayed a fine particle fraction (FPF) of 74.31±1.32% and mass median aerodynamic diameter (MMAD) of 1.70±0.03 μm indicating that the majority of the dose would be deposited in the respirable airways of the lungs. The …
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Development of Aerosolizable mRNA Incorporated Chitosan Nanoparticles for Efficient Lung Delivery
… particle size separation was performed using a Next-generation impactor (NGI). The aerodynamic characterization revealed that formulations had an optimal aerodynamic diameter between 1-5μm. Other properties like fine particle fraction and geometric standard deviation could be improved by …
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Creation and validation of an enhanced in vitro model of the lungs
… out modifications in the collection cups of the Next Generation Impactor (NGI) to allow incorporation of bacterial cultures for evaluation of formulation efficacy. The regular collection cup in the stage 4 of the NGI was replaced with a deep collection cup for incorporating bacterial cultures …
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Relative bioavailability of terbutaline to the lungs following inhalation using different methods.
… was measured using an Anderson Cascade Impactor (ACI) with a mixing inlet valve to allow measurement at different flows. A steady increase in total emitted dose (TED) and the fine particle dose (FPD) was observed as the inhalation flow increased thereby highlighting the flow dependent …