Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Newborn rats"”.
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Some metabolic effects of high oxygen concentrations in relation to retrolental fibroplasia
Newborn rats and young guinea pigs have been exposed to high oxygen concentrations with subsequent analyses of ascorbic acid in liver and brain tissue. Newborn vats show a depletion of liver ascorbic acid only after exposure to 100% oxygen. Extending the exposure period in 70% oxygen did not result …
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mRNA EXPRESSION ANALYSIS OF MIDBRAIN DOPAMINE NEURONS IN RESPONSE TO NICOTINE INTAKE DURING MATURATION
… between the VTA and the SN in the 24-month old rats. In addition, nicotine treatment did not show any up-regulatory effects on the expression of neuroprotective genes in rats after 12-months maturation. We also investigated the whole-genome expression of midbrain dopaminergic and …
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Effects of Neonatal Dexamethasone on the Maturation and Endowment of Cardiomyocytes
… the role of epigenetic modifications. In newborn rats, dexamethasone was administered in tapered, clinically relevant doses during the first three days of life. We found that newborn dexamethasone treatment induced premature terminal differentiation in cardiomyocytes resulting in reduced …
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Retinoic acid signaling after nerve injury
… in Schwann cell primary cultures isolated from newborn rats. After RA treatment the spatial distribution of RXRs and CRABP-II but not from RARs changed from a cytosolic to a nuclear localization, and CRABP-II was downregulated via RA. In the search for possible genetic targets of RA signaling I …
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
… in both splenectomized and non-splenectomized rats to verify the role of COX-2 in splenic immune cell responses following HI. We found that elevations in COX-2 expression by immune cells promoted IL-15 expression in astrocytes and infiltration of inflammatory cells; additionally, down-regulated …
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The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… Following the Rice-Vannucci model, seven-day old rats (P7) were subjected to unilateral carotid ligation followed by 2.5 hours of hypoxia. Our results show that both G-CSF and metyrapone significantly reduced infarct volume via anti-apoptotic properties but lost its protective effect when combined …