Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 159 for “"New treatment"”.
-
New Treatment Of The Pulsar Equation
… to converge. We have replaced relaxation with Newton's method in the context of solving nonlinear equations. This technique is demonstrated by replicating the results of Michel 1973, Contopoulos et al. 1999, Takamori et al. 2012, Lovelace et al. 2006, and Contopoulos et al. 2014. These altered …
-
New Treatment Options Of Diabetes Melitus
New line treatment options of Diabetes mellitus excluding surgical and other invasive procedure and focusing most on pharmacological options.
-
Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas
… brain cancer in adults despite aggressive treatments with surgery and chemo-radiation. Advances in electrotherapeutics offer a foundation for developing new treatment modalities that exploit an innate vulnerability of glioblastoma (GBM). Low intensity, non-ablative electric fields are …
-
Molecular Studies on Pathogenesis, Prognostic Factors, and New Treatment Options for Ovarian Granulosa Cell Tumors
… of GCTs are largely unknown. Further, the treatment of advanced or recurrent GCT is difficult underscoring the need for biologically targeted treatments for aggressive GCTs. The molecular mechanisms leading to GCT formation are likely to include regulators of granulosa cell proliferation …
-
The synthesis & optimisation of irreversible ITK inhibitors as a potential new treatment for severe asthma
Interleukin-2-inducible tyrosine kinase (ITK) is a member of the Tec family of non-receptor tyrosine kinases and plays an important role in T cell receptor signalling. Phosphorylation of ITK ultimately results in the release of several cytokines from T cells which are involved in the inflammatory …
-
Does the inclusion of the cost and burden of adverse drug reactions associated with drug-resistant TB treatment affect the incremental cost-effectiveness of new treatment regimens? A case study from the introduction of bedaquiline in South Africa National TB Programme
… and drug-resistant TB. Second-line TB treatment is less effective, more expensive, and more toxic than treatment for drug-sensitive TB. Nearly 1 in every 5 persons who starts treatment for drug-resistant TB in South Africa will die; 1 in every 3 persons who survives treatments …
-
Treatment of bacterial infections by intradermal medication
… He is easily prejudiced in favour of any new treatment, and has not the means at hand to test out results, using controls &c. But his greatest interest is in treatment. if any method: of treatment will relieve his patients of their suffering, either mental or physical, he is justified in …
-
Bayesian sample-size determination and adaptive design for clinical trials with Poisson outcomes.
… on the first-stage results. Lastly, we present a new Bayesian meta-analytic non-inferiority method for binomial data that allows researchers a more direct interpretation of their results. Our method uses MCMC methods to approximate the posterior distribution of the new treatment compared to a …
-
Neurofeedback as a treatment method: perceptions of the child and youth care workers at Durbanville children's home
… Children’s Home on Neurofeedback as a treatment method. It primarily considered the child and youth care workers opinions, as this target group is considered the primary carers of the children in the setting. The participants opinions are based on the implementation of Neurofeedback as …
-
Novel polymer constructs for controlled release and presentation of topographic cues in support of neuronal cells
In order to improve nerve healing, a new treatment that uses conductive polymer scaffolds to bridge gaps between damaged nerve ends and deliver drugs controllably was explored. In order to optimize neuron growth across scaffolding a neuronal scaffold designed with an electrically conductive …
-
Smoothed particle hydrodynamics
… applications. In this thesis, we present a new application of the SPH method: a new algorithm for computing a null divergence velocity field using SPH for incompressible flow - a pure SPH solution of the Helmholtz-Hodge decomposition. Also, a new version of the Laplacian for SPH is proposed …
-
Responder Identification in Clinical Trials
… for responder identification and it proposes a new method for systematic search for responders. The responder identification method consists of the following three steps: 1. Identification of prognostic factors (e.g. via Cox-PH model on the standard treatment arm) 2. Identification of patients …
-
Nitric oxide-induced DNA recombination & glycosaminoglycan mediated differentiation in stem cells
… of the HSGAG-biosynthetic machinery by chlorate treatment, or by the enzymatic degradation of the HSGAGs. Exogenous addition of heparin to chlorate-treated cells partially restored differentiation into endothelial cells. These effects were mirrored in phospho-ERK levels, suggesting the …
-
Hidden Failures in Shipboard Electrical Integrated Propulsion Plants
… power would put the ship as risk. This new treatment reduces the region of vulnerability by providing a high impedance boundary that limits the effects of a hidden failure of a current magnitude or differential based protective element, without the installation of any additional hardware …
-
The Role of Anti-Viral Immune Response on the Therapeutic Efficacy of Oncolytic Virotherapy for High-Grade Gliomas
<p>Currently, there is no effective treatment for high-grade gliomas that are resistant to conventional treatments and immune checkpoint blockade therapies. Oncolytic viruses offer a new treatment modality by selectively replicating in cancer cells and inducing anti-tumor immunity. Among these …
-
Methods for Using Biomarker Information in Randomized Clinical Trials
… clinical trials. Biomarkers which influence treatment efficacy may be used to find subgroups of patients who are most likely to benefit from a new treatment. Consequently, there is a growing interest in better approaches to identify biomarker signatures and utilize the biomarker information …
-
DESIGN & DEVELOPMENT OF HETEROTOPIC TRANSCATHETER TRICUSPID VALVES TO AMELIORATE TRICUSPID REGURGITATION
… advent of transcatheter technology gives them a new treatment alternative. However, so far, there has been no commercially available transcatheter tricuspid valve. This may be because of the complex tricuspid valve anatomy and the lack of an anchorage zone. Thus, the next best anchorage zone is …
-
Modified 3+3 Design for MTD Re-estimation
… to identify the maximum tolerated dose (MTD) for new treatment regimens. While this design is widely used due to its simplicity , it has some notable limitations, including a maximum of six patients per dose level and fixed target toxicity rates. To address these issues, we propose a modified 3+3 …
-
Anorexia, Self Harm and Depression: Exploring Internal Worlds and Underlying Deficits
… clinical understandings of anorexia and new treatment approaches.
Page 1 of 8