Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 21 for “"New Drug Development"”.
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Study of Product Line Complexity, Supply Chain Coordination, and Phase III New Drug Development
… industry. When companies invest in developing a new drug in the last phase of human clinical study, they often encounter uncertainty in patient enrollment and the unknown safety, efficacy, and tolerability of the new drug. To test new drugs, companies use clinical studies without interim analysis …
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Continuous processing of multiphase reactions for pharmaceutical applications
With current needs to expedite new drug development, reduce cost and increase availability of existing drugs, and improve stability and safety of pharmaceutical manufacturing, the continuous flow synthesis has appeared as an attractive alternative to the conventional batch processes. Numerous …
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QUB-1453: A Bioactive Peptide from the Defensive Skin Secretion of Rana amurensis
… potent bioactivity and pharmaceutical value for new drug development. In this thesis, QUB-1452, an AMP, was isolated and characterised from the skin secretion of Rana amurensis. The peptide is composed of 13 amino acid residues, FLPVLISLIGRLL, and is C-terminally amidated. The structure and …
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Engineering membrane-selective antibiotic peptides to combat multidrug resistance
… is a global health emergency that mandates new drug development strategies. Natural antimicrobial peptides (AMPs) have been long-recognized as a potential source of bacteriolytic drugs, but the shortcomings of non-specific membrane toxicity, proteolytic instability, and in vivo toxicity have …
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Targeting Oncogenic Mirnas With Small Molecules For Breast Cancer Therapy
… pathobiology has driven the introduction of new drug development approaches such as miRNA inhibition. In order to advance miRNA-therapeutics, there is a need to develop screening strategies that can target tumors in a specific way. Small molecule inhibitors represent an attractive approach to …
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A bioactive peptide from the defensive skin secretion of <i>Odorrana versabilis</i>
… The bioactive peptides could play a key role in new drug development. In this thesis, a bioactive peptide named QUB-1966, was isolated and characterised from the skin secretion of the Chinese Ranidae frog, Odorrana versabilis. The peptide consisted of 21 amino acid residues, …
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A novel two-component signal transduction system in propionibacterium acnes and its association with a putative extracellular signalling peptide
… of human skin, is thought to be involved in the development of inflammatory acne, which is an exclusive human disease affecting more than 80% of the whole population. Quorum sensing is the regulation of gene expression in response to cell density. As it is often involved in pathogenecity of …
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Predicting Toxin-Antitoxin Systems Responsible for Host-Induced Persistence of Burkholderia pseudomallei
… and targeting them provides an avenue for new drug development to reduce chronic infection. When investigating TAS, the predominant issue is the presence of a large number of TAS in an organism. Currently, there is no predictive model to determine which conditions toxins respond to. Because …
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Repurposing itraconazole as a novel and promising therapeutic strategy for pancreatic cancer
… expense needs to be considered, as the costs of new drug development have been increasingly shifted to patients which can negatively affect clinical outcomes and quality of life. Repurposing drugs offers a rational, evidence-based approach which can provide sustainable access to cost-effective …
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In vitro and in vivo investigation of the anticancer activity and molecular mechanisms of disulfiram in non-small cell lung cancer
… This study aims to repurpose disulfiram (DS), a drug used to treat alcohol dependence, into an effective treatment for non-small cell lung cancer (NSCLC). Lung cancer is the leading cause of cancer related death worldwide because of early metastasis and chemoresistance. Cancer stem cells (CSCs) …
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Pin1 Catalytic and WW Domain Ligands
… arthritis. Pin1 is a very promising target for new drug development. Three stereoisomers: (R,S)-, (S,R)- and (S,S)-Ac–pSer–Ψ[(Z)CH=C]–Pip–2-(2-naphthyl)ethylamine were synthesized as inhibitors binding to the Pin1 catalytic domain. The (R,S)- and (S,R)-isomers were synthesized via a 13-step …
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Computational Insights into the Antimicrobial Mechanism of Action of Class II Bacteriocins.
… the overuse of antibiotics, as well as a lack of new drug development. Coordinated efforts are needed to overcome this challenge, including discovery of alternative drugs. Bacteriocins are bacteria-produced, antimicrobial peptides that are potentially powerful antibiotic drug candidates. Despite …
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Towards depth-resolved multi-cubic-centimeter field of view endoscopic camera for intraoperative nerve identification.
… and avoids regulatory pathways associated with new drug development. However, because OCT offers high-resolution, three-dimensional imaging. A surgical OCT system supporting video-rate acquisition of cubic centimeter fields would require signal capture bandwidths that are several orders of …
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Small molecule inhibitors against enteric bacterial glycosyltransferases
… 100066N and 102644N show high potential in new drug development because they have advantages of not interfering with bacterial growth curve when added to the LB culture, no significant toxicity to mammalian cells, and do not cross-react with human OGT. However, we encountered difficulties …
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Bridging the gap : using extrapolation to reduce the experimental burden in children
When developing a new drug product for children, it is important to provide safe and effective medicines whilst minimising the experimental burden where possible. Extrapolating data from clinical trials in adults or other relevant populations has the potential to reduce the number or size of …
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Functional Characterization of Serine Hydrolases Mediating Lipid Metabolism and Protein Depalmitoylation in Asexual Stage Plasmodium Falciparum
… mosquitos. Due to Artemisinin resistance, new druggable targets identification and new drug development are urgently needed. Serine hydrolases (SHs) are one of the largest classes of enzymes having important roles in life processes. The deadliest malaria parasite, P. falciparum, encodes …
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Investigation of the anticancer activity and mechanisms of zinc diethyldithiocarbamate in multiple myeloma
… treatment options such as immunomodulatory drugs (IMiDs), proteasome inhibitors (PI), CAR-T therapy and antibody-based therapies have improved the prognosis of MM, all patients eventually relapse due to the presence and development of drug resistance. Therefore, the development of new drugs …
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A problem driven approach to the miniaturizsation and automation of enzyme-based assays and an investigation of the dissipation of cyanazine and bromide in wetland mesocosms
… something of an identity crisis. Its role in the development of instrumental methods frequently relegates it into the category of a technology, while the curiosity-driven fundamental studies of the technology drive it into the category of a science. Fortunately, it is possible to do both science …
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Investigation of the effect of disulfiram on the chemoresistance and invasiveness in pancreatic cancer cells
… resistant to currently available anticancer drugs and the resistant cells metastasize to vital organs leading to a high rate of fatalities. Cancer stem cells (CSCs) are responsible for chemoresistance, relapse and metastasis. It is widely accepted that CSCs are located in the hypoxic niche …
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Essays on Mathematical Modeling and Empirical Investigations of Organizational Learning in Cancer Research
After numerous renewals and reignitions since the initiation of the "War on Cancer" more than five decades ago, the recent reignition of "Moonshot to Cure Cancer" points to the systemic persistence of cancer as a major cause of loss of life and livelihood. Literature points to the diminishing …
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