Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"Nevirapine"”.
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Detection of positive selection resulting from Nevirapine treatment in longitudinal HIV-1 reverse transcriptase sequences
Nevirapine (NVP) is a cheap anti-retroviral drug used in poor countries worldwide, administered to pregnant women at the onset of labour to inhibit HIV enzyme reverse transcriptase. Viruses which may get transmitted to newborns are deficient in this enzyme, and HIV-1 infection cannot be …
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Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis
… are superior compared to those achieved with nevirapine-based ART [4] and concomitant TB treatment does not significantly reduce efavirenz concentrations [5]. However nevirapine is cheaper than efavirenz and is used extensively used in lower income countries with limited access to efavirenz …
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Pharmacokinetic-Pharmacogenetic-and-Pharmacodynamic Adherence Relationships in Cohort South African HIV Infected Children on Lopinavir-and Nevirapine-Based Regimens
… therapy (ART), notably lopinavir and nevirapine substantially reduces Human immune-deficiency virus (HIV) associated morbidity and mortality in HIVinfected children. Low concentrations of nevirapine and lopinavir have been linked to inferior virological outcomes; it is recommended that …
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Pharmacokinetics, pharmacogenetics and optimisation of treatment with non-nucleoside reverse transcriptase inhibitors in HIV-infected African children
Efavirenz and nevirapine are the most widely used agents for treatment of HIV in children. Sources of variability in their pharmacokinetics and its association with virological outcome and adverse events in African children are poorly characterised, thereby limiting treatment optimisation. To fill …
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The operational effectiveness of a single dose Nevirapine prevention of mother to child transmission of HIV/AIDS programme in Khomas region, Namibia
… the operational effectiveness of a single dose Nevirapine for PMTCT programme among infants aged six weeks in Khomas region of Namibia. Methods: This was a retrospective record review quantitative study based on a descriptive approach. The record review aimed at measuring operational …
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Factors associated with Nevirapine adherence in the prevention of mother-to-child transmission of HIV in the Free State province of South Africa and discrepancies between service records and cord-blood surveillance
… including South Africa using the simple nevirapine-based PMTCT regimen, found that prophylaxis coverage for the PMTCT of HIV was on average poor, at only 50% among HIV-exposed infants during 2007-2008. Incomplete HIV testing in pregnancy accounted for 46% of missed opportunities for PMTCT …
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Factors affecting Compliance in the uptake of Zidovudine(AZT) and Nevirapine (NVP) By HIV Seropositive Expectant women delivering out side a health facility in Lusaka
… in their third trimester of pregnancy and Nevirapine given intrapartum to mother when labor begins and postpartum to baby reduce the chance of Mother to Child Transmission of HIV. However, some studies have revealed that many HIV seropositive expectant women do not comply with the uptake of …
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Factors affecting Compliance in the uptake of Zidovudine(AZT) and Nevirapine (NVP) By HIV Seropositive Expectant women delivering out side a health facility in Lusaka
… in their third trimester of pregnancy and Nevirapine given intrapartum to mother when labor begins and postpartum to baby reduce the chance of Mother to Child Transmission of HIV. However, some studies have revealed that many HIV seropositive expectant women do not comply with the uptake of …
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Willingness to pay for VCT and nevirapine for the prevention of mother to child transmission of HIV in the Kassena-Nankana district of Northern Ghana
… of mother-to-child-transmission (PMTCT) and Nevirapine (NVP) is the cheapest, most feasible and highly cost-effective of all and suitable for resource poor settings. Voluntary Counselling and HIV Testing (VCT), known for its effectiveness in behavioral change, is also essential for the …
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The effectiveness of PMTCT in the Free State - An anonymously linked cord blood survey
… be seropositive were tested for the presence of nevirapine using chromatography. All PMTCT sites used single dose nevirapine as the minimum prophylaxis, a few used dual therapy including zidovudine and nevirapine and some included nevirapine-based HAART for eligible women. Information was also …
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Drug-drug interactions between antiretrovirals and bedaquiline
… cytochrome P450 3A (CYP3A). The antiretrovirals nevirapine, efavirenz, and lopinavir/ritonavir (LPV/r) can affect the activity of this enzyme, and consequently affect the concentration of bedaquiline in the patient's blood. Nevirapine and efavirenz increase the activity of CYP3A, which may result …
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Supramolecular derivatives of selected bioactive compounds : a physicochemical study
… (polymorphs), and the antiretroviral agent, nevirapine (co-crystals). The solubility and dissolution profiles of the three compounds and those of selected ‘supramolecularly-derived’ species were also assessed. Three distinct phases of 2-methoxyestradiol (2ME) were successfully isolated, the …
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Analysis of HIV early infant diagnosis and linkage to care in the Western Cape: a laboratory perspective
… and other Sub-Saharan countries, single dose Nevirapine, amongst other cost- effective regimens, have been adopted as part of the national HIV prevention program2 since 2003.
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Factors influencing the follow-up visits of mothers registered with prevention of mother to child transmission (PMTCT) of HIV/AIDS programme at the Katutura State Hospital
… HIV transmission in Namibia using Nevirapine (an Antiretroviral drug). The programme was initiated at two pilot sites i.e. Katutura State Hospital Antenatal Clinic (KSH-ANC) and Oshakati State Hospital. This programme was aiming to reach 500 HIV positive women, 250 from each site, …
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Estudos de modelagem molecular da piperina e CYP3A4 : a influência na biodisponibilidade de fármacos
… of propranolol, theophylline, phenytoin, nevirapine, rifampicin, nimesulide, pyrazinamide , carbamazepine, and spartein in the presence of piperine. The complex formed with piperine and CYP3A4 was shown to be the most stable of all, with the binding energy of - 8.60 kcal/mol. This explain …
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Supramolecular modification of selected antiretroviral drugs
… and attempt cyclodextrin complexation with nevirapine, efavirenz, lamivudine and zidovudine, with a view to identifying and isolating new solid forms of these drugs. Any new forms were to be characterised by a variety of analytical techniques, including thermal, spectroscopic and X-ray …
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Quantification, phase distribution, and persistence of antiretroviral drugs in wastewater treatment systems and their ecotoxicological impacts in aquatic environments
… ARVs, efavirenz (EFZ), emtricitabine (EMT) and nevirapine (NVP), examining their behaviour in conventional activated sludge (CAS) WWTPs and their potential effects on aquatic organisms. Seasonal monitoring of two WWTPs over two years showed consistent detection of all three ARVs in influent and …
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Measuring PMTCT effectivenss through HIV free survival in children under 2 years
… available at the time the guidelines recommended nevirapine in labour and to the child postpartum. Aim: The aim was to determine the effectiveness of the PMTCT program in the Free State by measuring HIV transmission and HIV-free survival in children less than two years of age. Variables associated …
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Morbidity from antiretroviral metabolic effects in Africa: The Mama Study
… diabetes in patients receiving efavirenz versus nevirapine containing regimens was compared with a Kaplan-Meier plot and a log-rank test. The association of efavirenz exposure with the hazard of developing diabetes was modelled using a multivariate Cox-proportional hazards model. The following …
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The sorption fate of active pharmaceutical ingredients in soils receiving high wastewater inputs and implications for risk assessments
… were ofloxacin, propranolol, naproxen and nevirapine, and represent a range of API physico-chemical properties. These experiments showed that the changes to soil properties (pH and dissolved organic carbon (DOC)) caused by irrigation with SWW can change the fate of APIs in soils. The …
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