Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Neutrophil extracellular traps"”.
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Neutrophil extracellular traps in periodontitis
This thesis has investigated the role of neutrophil extracellular traps (NETs) in the pathogenesis of periodontitis. A fluorometric assay was developed for the in vitro quantification of NET release and used to assess relative levels in chronic periodontitis patients, indicating elevated release …
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Induction of Neutrophil Extracellular Traps by Nontypeable Haemophilus Influenzae And Defense Mechanisms Against Host NETs and Oxidative Stress
Nontypeable Haemophilus influenzae (NTHi) is a Gram-negative commensal bacteria of the human nasopharynx. Normally residing in healthy individuals, NTHi rarely causes adverse effects. However, infection with NTHi in children often leads to middle ear inflammation and disease in the form of otitis …
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Synthesis, Radiolabeling and Evaluation of a suite of Tracers with <sup>44</sup>Sc for Detecting Extracellular DNA
<p>Neutrophil extracellular traps involve the rapid translocation of DNA to the outside of the cell under certain stimuli. This structure forms a fibrous network that is able to limit the spread of pathogens and to kill microorganisms. It has also been shown to be present in various pathological …
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Host-Defense Function of Anuclear Polymorphonuclear Neutrophil in Lung Injury
Polymorphonuclear neutrophils (PMN) function through rapid mobilization to the site of infection and are primary effectors of the innate immune response. Activated PMN extrude genomic DNA to form web-like structures called Neutrophil Extracellular Traps (NETs). After NET release (NETosis), the PMN …
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Human neutrophils generate extracellular vesicles that modulate their functional responses
Neutrophils influence innate and adaptive immunity by releasing various cytokines and chemokines, by generating neutrophil extracellular traps (NETs), and by modulating their own survival. Neutrophils also produce extracellular vesicles (EVs) termed ectosomes, which influence the function of other …
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Early and late events in NET formation
Neutrophils are immune cells that are central to host defense against infection and injury. Among other antimicrobial responses, neutrophils are known to produce NETs (for neutrophil extracellular traps) – networks of extruded decondensed chromatin adorned with antimicrobial molecules, which …
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Characterization of the Staphylococcus aureus Immunodominant Surface Antigen B, IsaB
… pH induce expression. We found that IsaB is an extracellular nucleic acid binding protein, able to bind to dsDNA, ssDNA, and RNA and leads significant accumulation of eDNA on the cell surface. We employed multiple virulence models to ascertain the role of IsaB in virulence. Excitingly, we found …
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Hypoxia induces selective neutrophil degranulation to promote endothelial damage in COPD
Neutrophils are the key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. They deploy pre-formed proteases packaged within cytoplasmic granules, generate reactive oxygen species and release neutrophil extracellular traps (NETs). However, these …
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Mild traumatic brain injury augments innate immune responses through neurokinin and cholinergic signaling
… mTBI-induced release of SP augments pulmonary neutrophil recruitment and microbicidal activity to pulmonary bacterial pathogens. In TT mice, NK1R agonism enhanced the same neutrophil functions, further supporting the hypothesis. No differences were found between mTBI and TT neutrophils’ ability …
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Development of 3D multicellular liver organoids derived from human induced pluripotent stem cells to model antiretroviral therapy induced liver injury
… oxidative stress, protein synthesis, neutrophil extracellular traps (NETs) formation, the ATP-dependent chromatin remodelling and necroptosis. Conclusion: We successfully generated multicellular 3D liver organoids consisting of hepatocytes, Kupffer cells and hepatic stellate cells. …
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Characterizing The Source of Neutrophil Elastase and Proteinase 3 Cross-Presentation In B-Cell Acute Lymphoblastic Leukemia
… antigen derived from serine proteases neutrophil elastase (NE) and proteinase 3 (P3). NE and P3 are primarily expressed in cells of myeloid lineage including granulocytes, bone marrow progenitors and myeloid leukemia. Our lab reported that NE and P3 are cross-presented by antigen …
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Autoimmune Consequences of Histone Deimination during Neutrophil Activation
… initiation of autoimmune reactions. One form of neutrophil cell death deserves attention because it occurs as a consequence of neutrophil activation, requires the post-translational modification of histones and results in the extracellular release of chromatin. The extracellular chromatin …
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Novel innate immune functions of saliva
… functions of the prime guardian leucocyte, the neutrophil. Saliva triggers a response via salival mucins, which stimulates neutrophils to undergo a rapid mode of cell death called NETosis, wherein the neutrophils extrude a web to catch microbes in the form of a DNA framework decorated with AMPs …
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
Innate immune recognition of extracellular host-derived self-DNA and self-RNA is prevented by endosomal seclusion of the Toll-like receptors (TLRs) in the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with …
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Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse by Rewiring the Immune Microenvironment
… through the recruitment of pro-tumorigenic neutrophils while downregulating macrophages and dendritic cells <em>in vivo</em>. scRNAseq informed us that while the loss-of-Brd7 led to upregulation of neutrophils, stress response CD4+ T cells and exhausted CD8+ T cells in vivo. Furthermore, …
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The effect of human cytomegalovirus on neutrophil survival, autophagy, and extracellular traps
Neutrophils provide a rapid first response to invading pathogens and orchestrate the immune response. They are able to employ potent antipathogenic mechanisms such as phagocytosis, reactive oxygen species (ROS) generation, protease release from granules, and formation of neutrophil extracellular …
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Characterizing Inflammatory Mechanisms in Hidradenitis Suppurativa
… nodule) and is marked by an increase of Th17 and neutrophil-related signatures. Given that inflammation in HS extends beyond visible nodules to perilesional skin, we asked if dermal inflammation also contributes to disease pathogenesis. Dermal tunnels, also known as tracts or sinuses, are …
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Understanding the biochemical properties and physiological function of the protein syncollin
… to be expressed in the gut, the spleen and in neutrophils. The protein contains intramolecular disulphide bonds and is present both free within the ZG lumen and tightly associated with the luminal leaflet of the ZG membrane; it is also secreted into the pancreatic juice. Syncollin is able to …
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Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease
… between immune cells (primary healthy human neutrophils) and motile Pseudomonas aeruginosa bacteria in an inflammation-rich microenvironment. Neutrophils, being the first responding immune cells to infection, defend by deploying various defense mechanisms either by phagocytosing and killing …
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