Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Neutrophil Chemotaxis"”.
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Neutrophil Chemotaxis in Multiple Chemoattractant Gradients
Chemotaxis, the phenomenon in which cells move in response to extracellular chemical gradients, plays a prominent role in the mammalian immune response. During this process, a number of chemical signals, called chemoattractants, are produced at or proximal to sites of infection and diffuse into the …
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An in vitro study of neutrophil chemotaxis
… accounts of methods available for studying chemotaxis in vitro and many reports of diverse compounds of biological origin with attractant, or chemotactic, properties for motile, phagocytic cells. In general, these reports tended to substantiate the belief that chemical substances generated …
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Molecular mechanisms of signal transduction in neutrophil chemotaxis
Neutrophils play a critical role in host defense against invading pathogens. Chemotaxis, the directed migration of cells, allows neutrophil to seek out the sites of inflammation and infection. Neutrophil chemotaxis as well as other type of cell migration are considered as cycles composed of highly …
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Spatiotemporal organization, regulation and function of traction during neutrophil chemotaxis
… our understanding of biochemical regulation of neutrophil chemotaxis, little is known about how mechanical factors control neutrophils’ persistent polarity and rapid motility. Here, by using a human neutrophil-like cell line and human primary neutrophils, we describe a dynamic spatiotemporal …
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Microfluidic platforms for studying cell behavior
Neutrophil chemotaxis and intercellular signaling via diffusible molecules are vital physiological processes in the human body. The two processes play a role in diseases and disorders such as rheumatoid arthritis, tumorigenesis, and sepsis. A better understanding of the two processes will aid in …
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Photoperiodic Effects on Immune Function in Dairy Cattle: Potential Mediation Through Prolactin and Its Receptor
… increased lymphocyte proliferation and neutrophil chemotaxis to levels observed in short day photoperiod treated animals. The experiments described in Chapters 2 and 3 examined the effects of photoperiod treatment during the dry period of multiparous Holstein cows. Dry matter intake …
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A Mathematical-Experimental Strategy to Decode the Complex Molecular Basis for Neutrophil Migratory Decision-Making
Neutrophils are the innate immune system's first line of defense in response to an infection. During an infection in the tissue, chemical cues called chemoattractants are released, which signal neutrophils to exit circulation and enter the tissue. Once in the tissue, neutrophils directionally …
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Engineering cellular microenvironments for directed cell growth and migration
… and (2) using microfluidic platforms for neutrophil chemotaxis. Both of these applications are of crucial importance in modern biological and medical advancement. We have developed micropatterned platforms for systematic analysis of tenocyte behavior on topographical surfaces. These …
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Significant Association of IL-18 Genetic Polymorphisms with Aspirin-Intolerant Urticaria in a Korean Population
… been fully understood, mast cell activation and neutrophil infiltration have been suggested to be involved. Interleukin-18 (IL-18) can stimulate mast cells and then release inflammatory mediators such as IL-4, IL-13 by stimulating mast cells. IL-18 activates neutrophils by inducing the production …
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Molecular signaling programs underlying neutrophil polarity and chemotaxis
Neutrophils adopt a highly polarized morphology and integrate many matrix-specific signals to undergo specialized migratory events to pursue invading pathogens. While these matrix-specific signaling events have emerged as crucial elements for proper migration and recruitment of neutrophil cells, …
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Microfluidic platforms for studying cell behavior in complex microenvironments
… and applying microfluidic platforms to study (1) neutrophil chemotaxis, (2) intercellular communication, and (3) cell behavior under controlled oxygen conditions. In chapter 1, conventional methods and emerging techniques using microfluidic platforms to study cell behavior in complex …
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Quantitative Image Analysis in the Study of Neutrophil and Neutrophil-Like HL-60 Chemotaxis
Neutrophils are fast-moving first responders of the innate immune system. External chemoattractant signals result in neutrophil polarization: the neutrophil forms a leading edge (front) which constantly protrudes and retracts actin-rich pseudopods, and a contractile myosin-enriched trailing edge …
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Biofilm-derived Small Molecules Released from Mixed-species Cultures of Fusobacterium necrophorum and Porphyromonas levii Inhibit Bovine Neutrophil Functional Responses
… infections are so difficult to eradicate. Neutrophils are critical first responder cells that are recruited to a site of bacterial colonization to initiate the inflammatory response. In this dissertation research, an in vitro system for the growth of mixed-species anaerobic biofilms was …
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In Vitro and in Vivo Pharmacodynamic Characterization of the Novel Plasma Kallikrein Inhibitor Pf-04886847
… activates the complement system and stimulates neutrophil chemotaxis, aggregation and elastase release. Furthermore, kallikrein mediates the conversion of factor XII (FXII) to activated factor XII (FXIIa) thereby potentiating the intrinsic pathway of coagulation. Thus, plasma kallikrein …
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Identification of a Minimal Cis-element and Cognate Trans-factors Required for the Regulation of Rac2 Gene Expression during K562 Cell Differentiation
… many hematopoietic cellular functions, such as neutrophil chemotaxis, superoxide production, cytoskeletal reorganization, and stem cell adhesion. Despite the crucial role of Rac2 in blood cell function, little is known about the mechanisms of Rac2 gene regulation during blood cell …
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Leukocyte Chemotaxis Activity by Cotyledons of Dairy Cows With Normal Delivery and Retained Placenta
… morphology of placentome carunular crypts and neutrophil chemotaxis response by cotyledons of normal and retained placentas of dairy cows, and to determine the effects of 5mg of dexamethasone on placental hormone profiles, placentome morphology and PMN chemotaxis response. Experiment 1: Group 1 …
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Differential Stimulation of Monocytes to Secrete Secretory Leukocyte Protease Inhibitor by Lipopolysaccharide of Periodontal Pathogens
… that LPS of periodontal pathogens suppresses neutrophil's ability to secrete super oxide ions and also shown it to interfere with neutrophil chemotaxis. These factors are believed to aid the pathogens to remain "stealthy" and avoid killing by the mononuclear phagocyte cells. Secretory …
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Mechanisms of microbial-host interaction during asymptomatic bacteriuria
… by a low but host-specific increase in neutrophil chemotaxis but IL-6 levels did not increase. To define the effects of genetic variation on the urine proteomic host response, patients were genotyped for polymorphisms that have been linked to susceptibility to ABU and urine samples from …
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Microfluidic processes to create structured microparticle arrangements and their applications
… arrays; microenvironment fabrication for neutrophil chemotaxis; and UCN-laden covert 2D tags for anti-counterfeiting. Lastly, we modified the porous microwell platform to a closed system, microfluidic channels, to park and isolate particles in monodisperse droplets surrounded by …
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The effects of a yeast probiotic, saccharomyces cerevisiae boulardii, on common sow stressors and their effect on maternal-fetal programming
… cortisol, natural killer cell cytotoxicity, neutrophil chemotaxis C5a and IL-8, Interleukin-12, and the leukocyte differential. Moreover, few treatment x day interactions occurred in piglets for any measure assessed during suckling or weaning, except for plasma cortisol, total white blood …