Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 77 for “"Neutralizing Antibody"”.
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Neutralizing antibody responses in HIV dual infection: lessons for vaccine design
… have been developed that elicit strain-specific neutralizing HIV antibodies in animal models, and are currently being evaluated in several human clinical trials. Identifying whether multiple immunogens could be administered to facilitate the broadening of responses represents a pivotal challenge. …
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Neutralizing antibody responses in HIV-1 dual infection : lessons for vaccine design
Includes abstract. Includes bibliographical references.
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Development and Characteristics of the Earliest Cross-Neutralizing Antibody Response to HIV-1
A neutralizing antibody response of sufficient potency, magnitude and duration is considered an important part of a successful HIV vaccine. A better understanding of the factors associated with the development of broadly neutralizing antibody responses (effective against a wide range of clinical …
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HIV-1 strain-specific neutralizing antibody responses and the dynamics of viral evolution
… immunity, it would need to elicit broadly neutralizing antibodies (bnAbs). However, factors underlying the development of these antibodies are not clear. There is evidence to suggest that in some individuals who develop bnAbs, the development of breadth is influenced by the co-evolution of …
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Development and Evaluation of an Isospora Suis Sporozoite Neutralizing Antibody Assay in Swine Testicular Cells
An in vitro Isospora suis sporozoite neutralizing antibody assay has been developed in swine testicular (ST) cells. This assay measures the titer of neutralizing antibodies present in sera, milk and monoclonal antibody culture fluids by determining both the amount of intracellular sporozoites by …
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Engineering of HIV gp120 by yeast surface display for neutralizing antibody characterization and immunogen design
… Virus (HIV) allows the virus to escape from antibody selection pressure. Certain conserved epitopes, like the CD4 binding site, are required for viral fitness and antibodies against these epitopes are able to neutralize HIV from multiple clades. Passive immunization experiments suggest that …
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Evaluating the neutralizing antibody response to HIV-1 membrane proximal external regional; Implications for vaccine design
Inducing broadly neutralizing antibodies targeting the HIV-1 envelope is thought to be crucial for developing an effective vaccine. The Membrane Proximal External Region (MPER) within the HIV- 1 gp41 envelope is a promising vaccine target. The MPER is highly conserved, functionally constrained, …
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The impact of neutralizing antibody and ADCC responses on HIV-1 envelope evolution in early infection
… HIV-1 vaccine remains a global priority. Neutralizing antibodies (nAbs), which block infection by cell-free virus, are likely to be an important response for vaccines to elicit. However, evidence from the RV144 vaccine trial and non-human primate vaccine studies suggest antibody-dependent …
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Humanized Mouse with a Diverse Polyclonal B Cell Repertoire as a Model for Neutralizing Antibody Responses against EBV and HIV
… has been historically difficult to model human neutralizing B cell responses to these two viruses using small animals. I leveraged a transgenic mouse model that encodes a genetically human antibody repertoire to generate neutralizing monoclonal antibodies (mAbs) against the EBV gp350 and gp42 …
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Assessing TMV as an immunogenic particle : the expression of HIV-1 subtype C V3 loop neutralizing antibody epitopes on the surface of TMV virions
… Human immunodeficiency virus-1 (HIV-1) subtype C neutralizing antibody stimulating vaccine, a Tobacco mosaic virus (TMV) derived vector was used to express recognized HIV neutralizing antibody epitopes. These epitopes were expressed on the surface of the TMV coat protein, which served as an ideal …
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Evaluation of Transmissible Gastroenteritis and Porcine Respiratory Coronavirus Immunologic Interaction in Seronegative Pregnant Gilts
… do not produce significantly higher TGEV serum neutralizing antibody titers when compared with gilts sensitized to either PRCV or TGEV alone, Anti-TOEV IgG and IgA levels were assayed for in post-farrow milks from all gilt groups. Only IgG was detected which indicated a lack of mucosal priming. …
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Antigenic profiling of the porcine reproductive and respiratory syndrome virus
… PRRSV-specific immunity, namely the weak virus-neutralizing antibody response upon infection or vaccination in pigs, in sharp contrast with the robust non-neutralizing antibody response. Chapter 1 summarizes the current literature on general aspects of the virus and the disease, PRRSV-specific …
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Understanding the interplay between HIV-1 diversity, humoral immune responses and viral fitness
HIV-1 antibody dependent cell cytotoxicity (ADCC) and neutralizing antibody (nAb) responses are both thought to be important responses to elicit through vaccination. This thesis characterises neutralizing response in two cohorts in Africa, and in a detailed study of one individual, elucidates the …
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Examination of HIV-1 diversity and evolution by a bioinformatics approach
… are under host immune response pressure. The neutralizing antibody, non-neutralizing antibody, and CTL responses were found to be the major forces driving genetic diversity of HIV-1 env and gag genes at population level. However, PS pressures on both Env and Gag proteins remain stable over …
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West Nile virus vaccination protects against Usutu virus disease in mice
… (E) protein on the outside of the virion. Neutralizing antibodies against both WNV and USUV have been found in birds and humans across Europe. In vitro cross-neutralization of WNV and USUV has been modeled experimentally and been observed in clinical settings. The neutralizing antibody …
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In vitro cytotoxic activity of equine lymphocytes on equine herpesvirus-1 infected allogenic fibroblasts
… if any correlation existed between virus-neutralizing antibody titers and the percent cytotoxicity. Results of the study indicate that <i>in vitro</i> cytotoxic activity of equine lymphocytes against EHV-1 infected allogenic fibroblasts can be measured with a standard 4 hour 51Cr release …
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Glycan Shielding of the Influenza Virus Hemagglutinin Elicits Evasion of the Adaptive Immune Response and T-Cell-Driven Pathology
… glycosylation of HA seems to shield neutralizing antibody epitopes while leaving T-cell epitopes unaffected. These results may be particularly significant in the context of the recent influenza pandemic.</p>
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Type I Interferon-Mediated Killing of Cancer Cells with IAP-Targeted Combination Immunotherapy
… is completely abrogated upon treatment with TNFα-neutralizing antibody. The synergistic effects are mediated by tumour cells and by contribution of immune cells, particularly macrophages and dendritic cells, as the systemic depletion of phagocytic innate immune cells results in an increase in …
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The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling
… we exposed cells to strain in the presence of a neutralizing antibody to TGF-P 1 and demonstrated that autocrine TGF-1l signaling was essential for load-induced HSPG production and sustained p38 MAPK and ERK activation.
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The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
… mouse model through continuous delivery of CCL2 neutralizing antibody. Despite the steady delivery of the antibody, CCL2 blocking did not significantly affect tumor progression. Examination of CCL2 level in blood and tumor sites revealed that CCL2 blocking significantly induced higher free CCL2 …
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