Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Neurulation"”.
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Cell mechanics-based modelling and in toto imaging describe a new mode of lumen formation in chicken neural tube
… single lumen remains constant. In chick neurulation, lumen formation is thought to employ two disparate processes that happen sequentially, as the neural tube forms from anterior to posterior. Anteriorly, and early in neurulation, the neural tube closes through primary neurulation, where …
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Fibronectin and Laminin, extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure in zebrafish
… nervous system, forms through the process of neurulation. During neurulation, a flat neural plate folds and the lateral edges bind to form a closed tube. Failure of neurulation results in neural tube defects (NTD). In humans, NTD causes life-threatening birth defects such as anencephaly, spina …
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The Role of Cell Division Orientation during Zebrafish Early Development
… required for neural rod midline formation during neurulation, but dispensable for body axis elongation during gastrulation. Our data indicate that SDO during both gastrulation and neurulation is dependent on the non-canonical Wnt receptor Frizzled 7 (Fz7), and that interfering with cell division …
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The role of actomyosin contractility in zebrafish neural tube formation through hollowing.
… brain and spinal cord through the process of neurulation. In amniotes, it forms in two different ways: in the anterior region, primary neurulation occurs through the folding of an already polarised epithelial sheet; and posteriorly, secondary neurulation occurs through de novo apical-basal …
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A multi-lineage in vitro mouse embryo model derived exclusively from mouse embryonic stem cells
… gastrulation, somitogenesis, cardiogenesis, and neurulation. However, it fails to recapitulate the spatiotemporal interplay of signalling pathways between embryonic and extraembryonic tissues. Another approach is to combine ESCs with extraembryonic stem cells (trophoblast stem cells (TSCs) and …
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Characterization of Dishevelled Associated Activator of Morphogenesis 2 (Daam2) in Wnt Signaling During Early Embryonic Development
… proper vertebrate gastrulation and subsequent neurulation. However, the mechanism(s) by how the non-canonical pathway mediates this actin cytoskeleton modulation is not fully understood. Identifying and characterizing novel signaling components of the non-canonical pathway remain essential to …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… is required for MFP formation during zebrafish neurulation. Unlike the previously known MFP inducing factors, mdka is not expressed within the embryonic shield or tailbud but is dynamically expressed in the paraxial mesoderm. I used epistatic and mutant analyses to show that Mdka acts …
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TWIST1: a subtle modulator of neural differentiation and neural tube formation
… is formed from epiblast precursor cells through Neurulation. Neural induction can be studied in its main aspects in vitro. However, the process is poorly understood, especially in regard to when and how a cell becomes specified, and then committed, to be a neural cell. It is, on the other hand, …
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Characterization of NHLRC2 gene-edited mice: a model for bovine developmental duplications
… hypothesize NHLRC2 plays a significant role in neurulation.
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Study of the Evolutionary Role of Nitric Oxide (NO) in the Cephalochordate Amphioxus, “<i>Branchiostoma lanceolatum</i>”
… the enzymatic NO production, during amphioxus neurulation, resulted in the alteration of pharyngeal structures formation in the larvae, in particular opening of the mouth resulted compromised. Moreover, an alteration in larva locomotion was observed. Further studies will be necessary to reveal …
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Elektroporation: Eine Methode zur Transfektion von Wirbeltierembryonen
… Beginn der Gastrulation bis hin zum Abschluß der Neurulation überzuexprimieren. Zur Analyse der veränderten Genexpressionsprofile wurde ein abgeändertes Verfahren der In-situ-Hybridisierung, basierend auf PCR generierten Matrizen entwickelt. Durch die Möglichkeit, ektopisch transiente …
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Ancient origins of the chordate forebrain: Conserved patterning of the anterior neuroectoderm in amphioxus
… lineage, the network was integrated to the neurulation program to specify retinal and hypothalamic areas of the forebrain. Furthermore, this work provides a comprehensive characterization of neuroarchitecture and cell type composition across the amphioxus life cycle, facilitating the …
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Mechanisms of Early Brain Morphogenesis
… studied. In contrast, other than the problem of neurulation: formation of the neural tube), developmental mechanisms in the nervous system have received relatively little attention. The central aim of this research is to characterize the biophysical mechanisms that shape the early embryonic …
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A Translational Approach to Modeling Unique Aspects of Germ Cell Development During Self-Organization of the Primate Embryo
… characteristics of implantation, gastrulation, neurulation, and organogenesis, as well as the curious marmoset phenotype of an elongated peri-gastrulation window, incorporating slowed embryonic growth and rapid extraembryonic development. In doing so, we generate an annotated ultrasound atlas of …
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The role of inherited determinants and embryonic-extraembryonic cell interactions in models of mammalian embryogenesis
Mammalian embryogenesis begins with the fusion of an oocyte and a sperm to create the first cell of the newly developing embryo called the zygote. The mechanisms by which this single cell generates a fully formed organism have long been the subject of study of experimental biologists. Initially, …