Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Neurovascular Coupling"”.
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Intrinsic Optical Imaging of Cortex During Deep Brain Stimulation: Parameters, Spatiotemporal Dynamics and Neurovascular Coupling
… DBS-induced neural and vascular response — neurovascular coupling, understanding which is necessary to interpret the data acquired with functional imaging techniques used in patients. Neurovascular coupling relationship was developed between 'maximum change in reflectance' (MCR, a measure of …
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Vertex-Based Analysis of Cerebral Blood Flow and Fractional Amplitude of Low-Frequency Fluctuations (CBF-fALFF) Coupling in Moderate-to-Severe Traumatic Brain Injury During the First Year Post-Injury
… injury (TBI) is known to involve damage in the neurovascular unit. TBI may disrupt the brain’s neurovascular coupling–the relationship between cerebral blood flow and neural activity–that can lead to cognitive and functional impairments. This study attempted to non-invasively investigate …
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Investigating mechanisms of hemodynamic control in the brain
Neurovascular coupling is the relationship between neural activity and blood flow that allows the brain to exhibit increases in blood flow to areas of elevated neural activity during sensory stimulation. It is these localized changes in blood flow, collectively known as the hemodynamic response, …
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Effects of Aerobic Exercise on Cognitive and Cerebrovascular Function in Hypertensive Adults
… during cognitive activity as a measure of neurovascular coupling. Adults with and without hypertension exhibit similar increases in large artery stiffness and decreases in extracranial hemodynamic pulsatility during cognitive activity, indicating similar neurovascular coupling between …
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Optical Cerebral Blood Flow Monitoring of Mice to Men
… I used optical techniques to characterize neurovascular coupling at several levels of cerebral ischemia in a rat model (Chapter 7). Neurovascular coupling refers to the relationship between increased blood flow and oxygen metabolism and increased neuronal activity in the brain. In the rat, …
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Advances in functional magnetic resonance imaging to facilitate brain research
… tortuous BOLD origins entangled with the complex neurovascular coupling. In this thesis, we provide effective solutions to each challenge in specific applications, aiming to advance the current fMRI technology to facilitate cutting edge brain research. We also demonstrate the feasibility of using …
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Segmentation et extraction de caractéristiques des vaisseaux sanguins cérébraux à l'aide de l'IRM
The neurovascular coupling is a growing field; it studies the effects of cerebral activity on the behaviour of cerebral blood flow (CBF) and the blood vessels themselves. With the help of magnetic resonance imaging (MRI), it is possible to obtain images such as susceptibility weighted imaging (SWI) …
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Simultaneous PET/fMRI for imaging neuroreceptor dynamics
… dynamics of the signals show that a direct neurovascular coupling between receptor occupancy and hemodynamics exists and that a temporal divergence between PET and fMRI can be used to investigate previously unexplored neurochemical parameters and adaptation mechanisms in vivo. Overall, our …
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Retinal Ischemia in the In Vivo Rodent: Cellular and Vascular Characteristics
… To determine the role of glial Ca2+ signaling on neurovascular coupling, we developed a method of injecting Ca2+ indicator dyes and caged Ca2+ compounds into the vitreous, near the retinal surface. This study demonstrated that glial Ca2+ signaling plays a role in retinal blood flow regulation. …
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Optical Imaging Of Tissue Physiology With Exogenous Contrast Agents
… for characterization of oxygen metabolism and neurovascular coupling in the brain. The second set of experiments developed instrumentation and a simple theoretical methodology for imaging fluorescent targets in turbid media such as tissue. This approach used the ideas of spatial frequency …
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Structural and functional imaging of the human and small animal eyes using ultrahigh speed Fourier domain optical coherence tomography
… hemodynamic imaging, and (7) imaging of neurovascular coupling in small animals using ultrahigh speed OCT.
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Predicting adverse neurological outcomes in infants receiving therapeutic hypothermia for hypoxic ischemic encephalopathy
… may have dysregulation in oxygen extraction, neurovascular coupling (NVC) or cerebral autoregulation in the cerebral cortical region of the brain. Future work should include increasing the sample size, enhancing data capture and machine learning (ML) algorithms, expanding follow-up to school …
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Biological Monitoring of Oxygen and Nitric Oxide: The Development and Characterisation of Real-Time Microelectrochemical Sensors.
… receptor (NMDA) and the potential role of NO in neurovascular coupling. Chapter 2 discusses the theory behind the project and Chapter 3 describes the experimental protocols utilised throughout this research. Chapter 4 discusses the development and characterisation of the monomer modified O2 …
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Robust and Cross-Domain Anomaly Detection and Mitigation
… Astrocyte Ca2+ Signals and Vascular Responses in Neurovascular Coupling) to assist researchers in identifying anomalous Ca2+ signals and their corresponding vascular responses.
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Relationships between subtle ocular changes and microvascular complications in people with type 2 diabetes
… patients with T2DM. •Reduced in FIV (relating to neurovascular coupling) was associated with retinal neurodegeneration, but not vascular markers, in T2DM. Conclusion: Together, these results indicate ocular pathologies in T2DM, even in the absence of complications. Diabetic ocular disease is not …
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Vliv oxidu dusnatého na průtok krve mozkem při neuronální aktivitě
Název práce Vliv oxidu dusnatého na průtok krve mozkem při neuronální aktivitě Cíl práce Cílem této diplomové práce bylo zjistit, zda aplikace 7-nitroindazolu, relativně specifického inhibitoru neuronální syntázy oxidu dusnatého, ovlivňuje bazální krevní tlak. Dále zjistit, zda má aplikace této …
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The Effects of Aging on EGFR/pSTAT3-Dependent Gliovascular Structural Plasticity
Astrocytes comprise the most abundant cell population in human brain (1). First described by Virchow as being 'glue' of the brain (2), modern research has truly extended our knowledge and understanding regarding the vast array of roles these cells execute under normal physiological conditions. …
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The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… the functional and structural integrity of the neurovascular unit (NVU). <br/><br/><b>Methods.</b> <i>Experimental Study 1: </i>In a randomised, single-blind cross-over design, 12 healthy, physically active male participants (age, 23 ± 2 yrs; BMI, 25 ± 4 kg/m<sup>2</sup>) were exposed to 6 hours …
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Spatiotemporal Dynamics of Tissue Oxygenation in Awake, Behaving Mice
Brain arterioles respond to local neural activity by altering regional blood flow patterns in a manner which optimizes oxygen supply to respiring cells (‘functional hyperemia’). Recent studies of functional hyperemia in awake rodents shows a bimodal arteriole diameter increase when neural activity …