Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"Neurovascular"”.
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An integrated neurovascular investigation of cognitive aging
… variations in cognitive aging are connected to neurovascular factors in a cascade fashion, and implicates how we might optimize future interventions aimed at mitigating cognitive aging. Further, it extends our current understanding of how age changes the modular organization of functional …
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Malarial retinopathy and neurovascular injury in paediatric cerebral malaria
… these features appear to reflect two processes: neurovascular sequestration (e.g. orange vessel discolouration and death), and neurovascular leakage (e.g. >5 sites of punctate leak and death). Respective adjusted odds ratios and 95% confidence intervals for these particular associations are: 2.88 …
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
… to widespread defects in homeostasis of the neurovascular unit, including increased intracerebral blood vessels with enhanced perivascular astrogliosis. Additionally, β8 integrin dependent defects in NSC proliferation, survival, and differentiation, as well as neuroblast migration in the RMS …
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Neurovascular mechanisms of cognitive aging: A multimodal neuroimaging investigation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2024-03-01 without embargo terms
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Mechanisms of Hypoxia-Induced Neurovascular Remodeling in PlGF Knockout Mice
Due to the high metabolic demand and low capacity for energy storage of the brain, neurons are vitally reliant on a constant oxygen supply. Under chronic mild hypoxic conditions (10% oxygen), angiogenesis is induced in the brain in an attempt to restore tissue oxygen tension to normal levels. In …
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Multimodal Imaging of Inflammation at the Neurovascular Interface in Cerebrovascular Disease
A carotid atherosclerotic plaque represents a nidus of inflammation mere centimetres below the blood-brain barrier. This inflammation, along with associated regions of microcalcification, are histopathological features of atheroma at risk of rupture (so-called “vulnerable plaques”) that trigger …
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Profiling the neurovascular cell interactions in alcohol exposure and HIV-1 infection
Alcohol use is known to exacerbate the progression of human immunodeficiency virus associated acquired immunodeficiency syndrome or HIV/AIDS in the brain, known as the NeuroAIDS. The mechanisms of this accelerated progression are still poorly understood. The purpose of my thesis is to review the …
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Fabrication and characterization of a magnetic bacterial nanocellulose for neurovascular reconstruction of cerebral aneurysms
A cerebral aneurysm is a condition where a defect protrudes out the arterial wall, and which is formed due among other reasons to abnormal high hemodynamic stresses that contribute to deterioration and dilation of the blood vessel. A desirable treatment of cerebral aneurysms is the complete cut-off …
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Neurovascular complications in displaced extension-type supracondylar fractures in children : outcome of conservative management
… was to review our conservative management of neurovascular complications in displaced extension-type supracond ylar fractures of the humerus in children. We critically analysed the outcomes. Our results shall aim to clarify the management of this contentious issue.
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Neurovascular implications of life-long exposure to contact in rugby union; the link to cognition
<b>Introduction</b>: Recurrent contact and concussion in sport represents a significant and growing public health concern which may contribute to long-term neurologic sequela in later-life. To what extent this relates to an accelerated decline in cerebral perfusion, a major risk factor for …
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Intrinsic Optical Imaging of Cortex During Deep Brain Stimulation: Parameters, Spatiotemporal Dynamics and Neurovascular Coupling
… DBS-induced neural and vascular response — neurovascular coupling, understanding which is necessary to interpret the data acquired with functional imaging techniques used in patients. Neurovascular coupling relationship was developed between 'maximum change in reflectance' (MCR, a measure of …
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The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… the functional and structural integrity of the neurovascular unit (NVU). <br/><br/><b>Methods.</b> <i>Experimental Study 1: </i>In a randomised, single-blind cross-over design, 12 healthy, physically active male participants (age, 23 ± 2 yrs; BMI, 25 ± 4 kg/m<sup>2</sup>) were exposed to 6 hours …
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Development and characterisation of a human in vitro model of the Neurovascular Unit using a biomimetic tissue engineered system
The neurovascular unit (NVU) is a complex structure comprising endothelial cells, pericytes, astrocytes, neurons, and extracellular matrix (ECM) elements. It plays an essential role in regulating cerebral blood flow and maintaining the integrity of the blood-brain barrier (BBB). Over the years, …
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Vertex-Based Analysis of Cerebral Blood Flow and Fractional Amplitude of Low-Frequency Fluctuations (CBF-fALFF) Coupling in Moderate-to-Severe Traumatic Brain Injury During the First Year Post-Injury
… injury (TBI) is known to involve damage in the neurovascular unit. TBI may disrupt the brain’s neurovascular coupling–the relationship between cerebral blood flow and neural activity–that can lead to cognitive and functional impairments. This study attempted to non-invasively investigate …
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Investigating mechanisms of hemodynamic control in the brain
Neurovascular coupling is the relationship between neural activity and blood flow that allows the brain to exhibit increases in blood flow to areas of elevated neural activity during sensory stimulation. It is these localized changes in blood flow, collectively known as the hemodynamic response, …
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An electronically steered, wearable transcranial doppler ultrasound system
… has been clinically indicated in a variety of neurovascular diagnostic applications. Acceptance of conventional TCD methods, however, has been primarily impeded by several constraints, including restrictive system form factors, measurement reliability concerns, and the need for a highly-skilled …
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Neuronal and Vascular Degeneration of the aging retina in the 3xTg-AD mouse
… deposition in the central nervous system (CNS), neurovascular dysfunction, and neuroinflammation. Diagnostic modalities to detect the early phases of these CNS pathologies in preclinical AD are inadequate. Vision abnormalities are common in AD, and Aβ and tau have been detected in the retina …
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