Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Neurotrophins"”.
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Memory, metals and neurotrophins
… to unravel the molecular mechanisms of memory. Neurotrophins are proteins involved in development and survival of neurons as well as they are active player in memory formation and synaptic plasticity. d-block biometals, especially copper and zinc, are emerging as crucial player in the physiology …
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Neurotrophins and neurotrophin receptors in adult primary sensory neurons
Neurotrophins regulate sensory neuron survival, differentiation and phenotype, yet much remains to be discovered. The role of neurotrophins and neurotrophin receptors in adult primary sensory neurons was investigated along three main avenues 'in vivo'. First, to better predict neurotrophin …
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Orthodontic tooth movement and neurotrophins in the rat dento-alveolar complex.
… tissue are distorted, leading to the release of neurotrophins and a common concomitant clinical response of pain and pressure. These neurotrophins may interact with cells within the dentoalveolar complex, including fibroblasts, endothelial and alveolar bone cells, resulting in the initiation of …
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Role of BDNF secretion and signaling in the activity-dependent refinement of synaptic connections
… (Kempermann et al, 2000; Ming and Song, 2005). Neurotrophins, a family of neuronal growth factors, are crucially involved in the modulation of activity-dependent neuronal plasticity. The first evidence for the physiological importance of this role evolved from the observations that the local …
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Interactions of Thyroid Hormones and Nerve Growth Factor in Normal Development of the Rat Hippocampus and Basal Forebrain and in Recovery From Early Hypothyroid Retardation
… by interactions of thyroid hormones with neurotrophins. We have found that hypothyroidism results in decreased hippocampal NGF levels, while up-regulating its receptors: the p75 neurotrophin and p140 trk A receptor. We propose that declining levels hippocampal NGF results in decreased …
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TrkB and gene expression
The neurotrophins are a family of secreted proteins that potently regulate diverse neuronal responses. Family members include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin 4/5(NT4/5). Neurotrophins bind the Trks receptor family (TrkA, B, …
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Effects of nerve growth factor on TGF-Beta,Smad signal transduction in PC12 cells
… superfamily are attributed to synergize with neurotrophins. Together, they mediate neurotrophic effects in different populations of the nervous system, suggesting that an interdependence exists between TGF-ßs on the one hand and neurotrophins on the other. In the present work, the crosstalk of …
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UNDERSTANDING THE INFLUENCE OF TDP-43 LOSS-OF-FUNCTION ON NEUROTROPHIN SIGNALLING
… Sortilin functions as a trafficking receptor for neurotrophins and a co-receptor in pro-neurotrophin mediated death, and its soluble form results in reduced activity-dependent secretion of BDNF, and potentiation of pro-neurotrophin related neurodegeneration. Mice with hippocampal depletion of …
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Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced by Neonatal Quinpirole Treatment.
… demonstrated a significant decrease in the neurotrophins nerve growth factor (NGF) in the hippocampus and brain-derived neurotrophic factor (BDNF) in the frontal cortex. Olanzapine treatment alleviated the decrease in NGF. The results suggest that olanzapine eliminates cognitive impairment …
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The morphology, neurochemistry, and consequences of sympathosensory plexuses
… survival of neurons depend on the function of neurotrophins such as nerve growth factor (NGF). One population of neurons that rely heavily on NGF for axonal growth and survival is the postganglionic sympathetic neurons. Trauma or disease resulting in injury to the peripheral nervous system …
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The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
Neurotrophins are neuromodulatory proteins utilised within neuronal networks for development and survival. Based on previous evidence revealing the expression of neurotrophin components in immune cells, the present study investigates neurotrophin component expression within Burkitt’s Lymphoma B …
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Chronic Stress Effects on Prefrontal Cortical Structure and Function
… studies will assess the roles of serotonin and neurotrophins in mediating these changes.</p>
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Expression and Requirement of Epithelial Fatty Acid- Binding Protein in Neuronal Axon Growth
… P15 retinal cells cultured in the presence of neurotrophins contained 6-fold more E-FABP-positive RGCs relative to controls. Taken together, these results indicate that: (1) E-FABP is expressed in differentiating PC12 cells and RGCs, (2) E-FABP plays a functional role in the elaboration of …
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Localization and Function Of RNA Interference in the Cerebral Cortex
… of signal transduction pathways, including neurotrophins such as brain derived neurotrophic factor (BDNF). Though previous experiments have shown up-regulation of neurotrophins and their receptors in reorganized cortex, it is necessary to remove these factors to definitively prove their …
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Chronic Stress Promotes Tumor Growth Through Increased Bdnf Production and Neo-Innervation
… (NE) leads to increased expression of several neurotrophins, including brain-derived neurotrophic factor (BDNF). Neurite extension assays showed that media conditioned by ovarian cancer cell lines is capable of inducing neurite outgrowth in differentiated neuron-like PC12 cells, and NE …
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Mitochondrial Instability, Lack of Erk1/2 Activation and High Expression of P75NTR in Engrailed-Deficient Mesencephalic Dopaminergic Neurons
… be inhibited by application of TrkB/C-specific neurotrophins, BDNF, NT4 or NT3, by siRNA knockdown (of P75) or by addition of an inhibiting antibody for P75. The rescue effect of these survival factors is diminished by concurrent treatment of the primary cell cultures with an inhibitor of the …
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Early Effects of Organophosphate Compounds on In Vitro Intracellular Signaling and Levels of Active Neurotrophin Receptors, and on In Vivo Neurotrophin Concentrations
… investigated the changes in levels of neurotrophins in vivo and how in vitro levels of neurotrophin receptors and their downstream signaling cascades are affected after exposure to OP compounds. We also characterized the molecular weight of a soluble factor responsible for inducing …
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Voluntary Exercise and Neurotrophin Signaling Affect the Development and Presentation of Painful Neuropathy
… of DN, to investigate how diabetes alters neurotrophins and to determine if voluntary exercise is capable of reducing PDN. Initial studies used a model of obese, type 2 diabetes and investigated if voluntary exercise could reverse PDN. Diabetes resulted in mechanical allodynia, yet because …
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Nose to Brain Delivery of Therapeutic Agents
… In this study, the plausibility of delivering neurotrophins [nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF)], neurotrophinogenic agents (ex: carnosic acid) and antibiotics (ex: cefotaxime) to brain via nose-brain pathway using chitosan as barrier modulating agent was …
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