Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"Neurotrophic factors"”.
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Effects of Neurotrophic Factors on Osteoblast Growth and Differentiation
… by the release or secretion of osteogenic growth factors in the form of neuropeptides. These neuropeptides could act locally on osteoblasts to increase bone formation and/or mineralization. Since calcitonin gene-related peptide (CGRP) and Substance P (SP) are the most abundant neuropeptides …
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On The Future Of Antidepressant Treatments: Targeting Neurotrophic Factors And Plasticity
For 60-plus years the explanatory model for Major Depressive Disorder (MDD) has been the monoamine theory, which states that low levels of monoamine neurotransmitters or alterations in their post-synaptic receptors are responsible for depressive symptoms. Drugs designed to elevate synaptic …
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Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin
… the survival and growth of brain cells, called neurotrophic factors. There are also neuropeptides, which are involved in signaling between brain cells. Both neurotrophic factors and neuropeptides have been shown to have an important role in suppressing epileptic activity. In this thesis, we …
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Nicotine Sensitization in a Rodent Model of Schizophrenia: A Comparison of Adolescents, Adults, and Neurotrophic Factors.
… than controls given nicotine. Brain-derived neurotrophic factor (BDNF) was analyzed in the nucleus accumbens. BDNF was significantly increased in nicotine treated adolescent females but was not affected in males. Nicotine alleviated BDNF deficits in D2-primed adults. These results suggest …
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Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
… the secondary mechanism of TBI depends upon two factors: injury severity (mild, moderate or severe) and location of the primary injury. Secondary brain damage has been known to involve neuroinflammatory, apoptotic and oxidative stress mechanisms which are mainly dependent on intracerebral …
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The Role of Raf-mediated Signalling Pathways for Motoneuron
… mouse embryos, after addition or withdrawal of neurotrophic factors to induce Raf kinases activation in vitro. Furthermore, in order to investigate the potential anti-apoptotic function of Raf kinases on motoneurons, we isolated motoneurons from B-raf-/- and c-raf-1-/- mouse embryos and analysed …
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Opto-mechanical control of nerve growth
… ability of peripheral nerves. Among those neurotrophic factors, topography, and electrical stimulation have been proposed to enhance nerve growth. This thesis explores optogenetic neural stimulation as a means to control neurite growth that promises greater cell-type specificity than …
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Roles Of Neuregulin1 In Neuromuscular Junction Development
… neuronal growth and differentiation factors that are important for many aspects of nervous system development. In this thesis, both the effects of NRG1 on NMJ development and reciprocal effects of neurotrophic factors on NRG1 expression were studied as a means to define the complex …
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Identification and characterization of a novel neurotrophic factor secreted by a mouse Schwann cell line
During development, neurotrophic factors regulate morphologic and functional differentiation in addition to their role as regulators of neuronal survival. Schwann cells are the major glial elements in the peripheral nervous system and, therefore, could play a major functional role in supporting …
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Immuno-suppressive hydrogels for stem cell therapy after traumatic brain injury
… immune cells and to increase the expression of neurotrophic factors that promote the survival of the neuronal tissue surrounding the injury site. However, the active rejection of the transplanted MSC by the host immune system could strongly diminish the stem cell's survival and therapeutic …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
… gliosis and the production glial-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Therefore, the aim of these studies was to determine the involvement of OPN and an RGD containing peptide in the regulation of glia and neurotrophic factors in the …
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Peptide hydrogels as novel scaffolds for dental pulp cell culture
… from the dental pulp (DPCs), and/or growth factors for regeneration of the dentine-pulp complex. <br/><br/>In this project, the viability of DPCs was determined in vitro with inhouse synthesised ultrashort peptide hydrogels (NapFFKK-OH and NapFFK’K’-OH) as well as commercially available …
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Transcriptional regulation of human mu-opioid receptor gene: functional characterization of activating and inhibitory transcription factors
… of immune cells and systemically acting soluble factors such as antibodies, cytokines, and chemokines. Its short-range communication either is mediated by locally acting soluble factors or transpires during direct cell–cell contact across specialized areas called “immunological synapses” …
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Astrocyte-mediated immune modulation during mycobacterial infection
… of well-described pro- and anti-inflammatory factors as well as chemotactic factors following mycobacterial infection. Furthermore, increased expression of neurotrophic factors by astrocytes was observed, which can assist in the recovery and repair of the CNS during CNS-TB. By supporting the …
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Nitric oxide induces chromatin remodelling in the developing central nervous system
… for limited survival and growth promoting factors, such as neurotrophic factors. The neurotrophin brain-derived neurotrophin factor (BDNF) has been shown to play an important role in proliferation and differentiation of cortical neuronal precursors (Bartkowska et al 2007). Moreover, BDNF …
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Iron deficiency affects spatial learning in neonatal piglets
… prefrontal cortex. Gene expression of several neurotrophic factors and proinflammatory cytokines, as well as whole-brain and hippocampal volume, were not affected.
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… showed that MPTP induced glial cell line-derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF) in the substantia nigra (SN). Interestingly, treatment with EP prevented degeneration of nigrostriatal DA neurons, increased striatal dopamine levels, and improved motor function. …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… is known to promote neuronal brain-derived neurotrophic factors (BDNF). Lithium is also an inhibitor of glycogen synthase kinase-3 beta (GSK-3-β). We analyzed biomarkers obtained from participants in a randomized placebo-controlled trial of lithium in ART-treated individuals with moderate or …
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NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES
… containing a multitude of neuroprotective and neurotrophic factors, was selected as ASC-CM has been previously shown to be neuroprotective by using both animal and cell culture models of neurodegeneration.
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Regulation der Capsaicin-Sensitivität von murinen Spinalganglienzellen durch neurotrophe Faktoren
In der vorliegenden Arbeit konnte anhand von Zellkulturen von Spinalganglienzellen herausgearbeitet werden, dass die Regulation der Capsaicin-Sensitivität in der Maus von vielen Faktoren abhängig ist: Es ließ sich ein komplexes System der Regulation von Capsaicin-induziertem Cobalt-Uptake als …
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