Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Neurotransmitter Agents"”.
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Structure and Function of Proteins Involved in Regulated Secretion: Synaptotagmins and Complexin
The release of neurotransmitter from neurons is a tightly regulated process. There are a number of proteins required for membrane fusion to occur, and then there are regulatory proteins that allow membrane fusion to proceed at incredible speed with the precise timing necessary for complex functions …
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Membrane Lipids and Synaptic Vesicle Trafficking in the CNS
… Moreover, all synapses experience spontaneous neurotransmitter release which may originate from the random exocytosis of vesicles prepared to fuse immediately upon calcium influx; however, spontaneously fusing vesicles may be independent because they prefer spontaneous fusion. The functional …
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Dissection of the Roles of Synaptotagmins in Calcium Dependent Neurotransmitter Release
Neuronal communication is mediated by neurotransmitter release, which is triggered in response to a calcium influx into the presynaptic cell, caused by the arrival of an action potential. Synaptotagmins (Syts) mediate this calcium-dependent regulation of neurotransmitter release by mechanisms that …
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Biochemical studies on the functional and metabolic roles of glycine in the central nervous system and its comparison to some other amino acids
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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In vitro release of endogenous monoamine and amino acid transmitters from rat brain synaptosomes
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Mechanistic Insights into the Role of Munc13 in Synaptic Vesicle Docking, Priming, and Fusion
Neurotransmitter release is a fundamental aspect of neuronal communication that relies on the fusion of synaptic vesicles with the presynaptic membrane. These fusion events are tightly regulated by the influx of Ca2+, which is sensed by the complex protein machinery at the axon terminal. In order …
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Understanding the Structure and Function of GABAA Receptors Using Cryo-Electron Microscopy
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Structural Studies of Complexin/SNARE Interactions
Vesicular neurotransmitter release is mediated by exocytosis of synaptic vesicles at the presynaptic active zone of nerve terminals. The Ca2+-triggered release process is extremely fast, lasts less than half a millisecond, and is tightly regulated by Ca2+. Action potentials cause Ca2+ influx …
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Insights into the Functions of Munc18-1 in Neurotransmitter Release
Neurotransmitter release is an exquisitely regulated process that transmits signals between neurons. The release process includes: docking of synaptic vesicles at the active zone of the pre-synaptic plasma membrane, priming to a release ready state, and then membrane fusion and release of …
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Unraveling the Functions of Synaptotagmin and Munc13 in Neurotransmitter Release
Neurotransmitter release is a central event in interneuronal communication. The release machinery includes three SNAREs (soluble N-ethylmaleimide sensitive factor adaptor protein receptor) and Munc18-1 as core components. Munc13, synaptotagmin and complexin underlie the exquisitely tight regulation …
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Microdialysis in the study of GABA and other putative amino acid neurotransmitters in the dorsomedial hypothalamus
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Towards a Better Treatment of Parkinson's disease
<p>Current therapies for Parkinson's Disease, the second most common neurodegenerative disorder, do not prevent disease progression, and induce extremely detrimental side-effects. Improving the best current pharmacological therapy, L-DOPA, carries important clinical benefits, partly by reducing the …