Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 44 for “"Neurotoxins."”.
-
Tetrahydroisoquinoline Neurotoxins in Parkinson Disease
<p>The goal of this dissertation work was to (1) determine the distribution of several tetrahydroisoquinoline (TIQ) derivatives in rodent, normal human and Parkinson disease (PD) brain, (2) quantify the levels of these TIQ derivatives in common food sources in an effort to link specific food intake …
-
CYP2D in the Brain Alters Response to Drugs and Neurotoxins
… that metabolize many centrally acting drugs and neurotoxins. In humans, CYP2D6 is genetically polymorphic, resulting in variable activity. CYP2D in the liver is regulated primarily by genetics, while CYP2D in the brain is affected by genetics and other factors, including xenobiotic induction and …
-
Untersuchungen zur endogenen Bildung, Cytotoxizität und DNA-schädigenden Wirkung des dopaminergen Neurotoxins TaClo
… von TaClo im Menschen sowie den Einfluß dieses Neurotoxins auf die DNA herauszuarbeiten und näher zu untersuchen. Im einzelnen wurden folgende Ergebnisse erzielt: TaClo schädigt die DNA, wie Versuche an zellfreier DNA und in-vitro-Experimente an PC12-Zellen belegen. Die endogene Bildung von …
-
Serotonergic and dopaminergic systems as targets for exogenous neurotoxins causing a parkinsonian syndrome
This thesis explored the mechanism of action of MPTP and its toxic metabolite, MPP⁺, and compared it to the mechanism of action of haloperidol metabolites, some of which are found in schizophrenic patients. Experiments assessed the effects of these compounds on several aspects of amine uptake in …
-
Interactions of insecticidal spider peptide neurotoxins with insect voltage- and neurotransmitter-gated ion channels
Two families of peptide neurotoxins that target insect large-conductance calcium-activated potassium channels (BKCa) have been isolated from the venom of two unrelated spiders. The ƙ-TRTX-Ec2 toxins are a family of three homologous peptides isolated from the African tarantula, Eucratoscelus …
-
Toxicology of Three Plant Neurotoxins in Drosophila Melanogaster, Gallus Gallus Domesticus, and Mus Musculus
To elucidate the fate of coniine within the body, the feces, urine, and body tissues of house mice were examined after oral administration of a sub-lethal dose of coniine. Coniine was quickly eliminated.
-
From Small Molecules to Neurotoxins: Characterizing Neuromodulatory Compounds Using Liquid Chromatography Coupled to Mass Spectrometry
Thus, this work demonstrates mass spectrometric approaches for analyzing biological samples from a variety of animal models resulting in detailed chemical and structural characterization of highly modified toxins, neuropeptides, and small molecules, which can ultimately contribute to our …
-
Tick toxinology : isolation and characterisation of the toxin from the Australian paralysis tick, Ixodes holocyclus
… species of ticks have been reported to secrete neurotoxins which can be fatal to mammals, including man. Envenomation by the Australian paralysis tick, I. holocyclus, is a considerable veterinary problem affecting tens of thousands of domestic and native animals each year. Envenomation is …
-
THREE-FINGER TOXINS AS SELECTIVE PROBES TO DISTINGUISH SUBUNIT INTERFACES OF NICOTINIC ACETYLCHOLINE RECEPTORS
… are a major family of snake toxins, containing ?-neurotoxins and ?-neurotoxins that selectively antagonize postsynaptic nicotinic acetylcholine receptors (nAChRs). For the first time, the cryo-EM structure of a natural ?-neurotoxin, Erabutoxin-A (Ea), complexed with Tetronarce californica nAChR …
-
The Examination of the Link Between Pesticides in Food and Learnig Disorders in Children
… children.</p> <p>Pesticides that are established neurotoxins have been used for decades in agriculture and home gardening. The research literature on pesticides in food and their impact on children's behavior was examined. Other literature examined the effect of neurotoxins on the human body. A …
-
STRUCTURE, FUNCTION AND FOLDING OF THREE FINGER TOXINS
… the same acetylcholine binding pocket as the -neurotoxins, it lacks key functional residues. In this thesis, I describe the three-dimensional structure of Oh9-1 by NMR. Unlike the above class of postsynaptic neurotoxins, we identified a 3FTx that acts at the presynaptic site. This toxin, …
-
The Delayed Neurotoxicity of Thio-, Allylthio- and Dithio-Carbamates and Its Relevance to a Mode of Action
… hen. Several carbamates proved to be delayed neurotoxins with this ability being particularly concentrated in the thiocarbamates bearing short, unbranched alkyl sidechains. The toxicity of these compounds was further examined in Musca domestica (LD(,50)) and Culex quinquefasciatus (LC(,50)) to …
-
The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
… of several classes of insecticides/drugs/neurotoxins to the striatal dopaminergic pathway and their potential relationship to Parkinsonism in the C57BL/6 mouse model, using biochemical and molecular biology methods. In the first objective, I investigated the neurotoxicity in striatal …
-
ANALYSIS OF PROTEASE ACTIVITY USING MEMBRANE- COATED BIOMIMETIC MICROSPHERES
Poisoning by Botulinum Neurotoxins (BoNTs) leads to the severe neuroparalytic illness known as botulism, which is characterized by flaccid paralysis, respiratory failure, and death. BoNTs are the most acutely toxic substances on the planet, so detection at physiologically relevant concentrations is …
-
Behavioral, Neurochemical, and Histological Characterization of Mice Deficient for Parkin, DJ-1, and Antioxidant Proteins
… dismutase are more sensitive to dopaminergic neurotoxins whereas mice with increased levels of superoxide dismutase are more resistant to dopaminergic neurotoxins. We predicted that reducing levels of antioxidant proteins in parkin-/-DJ-1-/- mice would result in age-dependent nigral cell loss, …
-
Impacts of developmental exposures to the harmful algal bloom toxin domoic acid on neural development and behavior
Harmful algal blooms (HABs) can produce potent neurotoxins that accumulate in seafood and affect human health. One HAB toxin of concern is domoic acid (DomA), a glutamate analog produced by the marine diatom Pseudo-nitzschia spp. Current regulatory limits are designed to prevent acute neurotoxicity …
-
A combinatorial approach to the search for anticonvulsant agents from gou teng and tian ma
… (MES) and neuronal cells insulted by neurotoxins. The results showed that neither of the herbal extracts could protect mice from MES induced seizures, but some compounds found in Tian Ma and the new synthesized 2-oxindole derivatives could be acting as neuroprotectants against …
-
In Vitro Metabolism Study of Brevetoxins by LC-ESI-MS
<p>Brevetoxins are natural neurotoxins that are produced by "red tide" algae. In this study, brevetoxin-1 and brevetoxin-2 were incubated with rat liver hepatocytes and rat liver microsomes, respectively. After clean-up steps, samples were analyzed by liquid chromatography (LC) coupled with …
-
Functional genomics of a non-toxic Alexandrium lusitanicum culture
… of shellfish contaminated with a family of neurotoxins called saxitoxins. Many species in the dinoflagellate genus Alexandrium have been shown to produce these toxins. Here I report the first case of a culture of Alexandrium that has completely lost the ability to produce saxitoxins. The …
Page 1 of 3