Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Neurotoxicology"”.
-
Unique applications of cultured neuronal networks in pharmacology, toxicology, and basic neuroscience
… and drug development, biosensors and neurotoxicology, and the study of burst and synaptic mechanisms. Chapter 1 details the testing of seven novel AChE inhibitors, demonstrating that neuronal networks rapidly detect small molecular differences in closely related compounds, and reveal …
-
The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
Parkinson's disease (PD) is an age-related neurodegenerative disease, which is characterized by severe loss of dopaminergic neurons in the substantia nigra pars compacta (SNc) and consequent dopamine depletion in its projecting area. In this dissertation, I evaluated the neurotoxicity of several …
-
Systems Genetics and Systems Biology Analysis of Paraquat Effects in BXD Recombinant Inbred Mice
… systems biology approach in the complexity of neurotoxicology and provides clarification of pathways that may underlay sPD pathogenesis.</p> <p>Abstract (Spanish) El paraquat (PQ) es un herbicida que se utiliza en muchos países, incluyendo Estados Unidos. También es muy tóxico para los humanos …
-
Investigation of Drp1 inhibition as potential therapy in pesticide-based models of Parkinson's disease
In this study I explored the impact of Drp1 inhibition on pathology in two different pesticide-based models of Parkinson’s disease, and found that paraquat induced autophagy blockade in vitro, which was abrogated by inhibition of Drp1 function through siRNA knockdown or expression of the Drp1K38A …
-
Organophosphorus Pesticide Exposure Effects on Neurobehavioral Development of Zebrafish and Characterization of Developmental Switch Between Two Cation-chloride Cotransporters (zfnkcc1 and zfkcc2)
<p>Organophosphorus pesticides (OPs) are neuroactive compounds that can affect the development of the nervous system and behavior. Using zebrafish, we compared the effectiveness of three different OPs, chlorpyrifos (CPF), diazinon (DZN) and parathion (PA) on survival, AChE inhibition and larval …
-
Pesticides and pesticide combinations on brain neurochemistry
Pesticides have been suggested to play a role in the development of many neurodegerative diseases including Parkinson's disease and Alzheimer's disease. Additionally, it has been suggested that exposure to pesticides and other environmental chemicals during the early stages of life could result in …
-
Neurological Effects of Low-Level, Chronic Domoic Acid Exposure in a Nonhuman Primate Model
Global oceans play an important role in many aspects of human life. We build our homes on the shores, take our food from the waters, and create our economies from the wealth of resources in marine waters. There is a growing recognition, however, that certain species of marine algae produce potent …
-
Effects of bisphenol A exposure during early development on behavior and anatomy of the prefrontal cortex in adult male and female rats
Previous work has shown that exposure to bisphenol A (BPA) during early development can affect behavior and sexual differentiation of the brain in rodents, although few studies have examined effects on cognitive behavior and associated areas of the brain. The current study examined if exposure to …