Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 172 for “"Neurotoxicity"”.
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Neurotoxicity of environmental pollutants
… the food industry. This study investigated the neurotoxicity of the most commonly used groups of BFRs and APs on SH-SY5Y human neuroblastoma cells. The results presented in this thesis showed (using cell viability assays) that these pollutants are toxic at low concentrations. Some compounds such …
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The neurotoxicity of acrylamide
The experiments described in this thesis compared conventional methods of screening for neurotoxins with potential electrophysiological and pharmacological tests in an attempt to improve the sensitivity of detection of progressive distal neuropathy. Adult male albino mice were dosed orally with the …
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The Neurotoxicity of Insecticides to Striatal Dopaminergic Pathway
… area. In this dissertation, I evaluated the neurotoxicity of several classes of insecticides/drugs/neurotoxins to the striatal dopaminergic pathway and their potential relationship to Parkinsonism in the C57BL/6 mouse model, using biochemical and molecular biology methods. In the first …
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Mechanisms Regulating Amyloid Processing Enzymes in HIV-Associated Neurotoxicity
… HAND as well as in our cell culture model of HIV neurotoxicity. Additionally, ADAM10 is decreased in response to excitotoxicity, a process crucial to HAND pathology, suggesting that there might be a shift in APP secretases contributing to HIV-mediated neurotoxicity. Therefore, understanding the …
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Pharmacological determinants of oxaliplatin neurotoxicity in patients undergoing cancer chemotherapy
… gastrointestinal cancers. Oxaliplatin-induced neurotoxicity often compromises treatment delivery and causes long-lasting neurological deficits that negatively impact upon patient's quality of life. Calcium and magnesium (Ca/Mg) infusions had been suggested as an effective intervention for …
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Mechanisms of DNA double strand break-mediated neurotoxicity in neurodegenerative disease
Neurons are highly susceptible to DNA damage accumulation due to their large energy requirements, elevated transcriptional activity and long lifespan. DNA double strand breaks (DSBs) are also linked to neurodegeneration and senescence. However, it is not clear how DSB-bearing neurons influence …
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Evaluation of Novel Carbamate Insecticides for Neurotoxicity to Non-Target Species
… vector control agents were selected for further neurotoxicity testing in non-target organisms. For commercial carbamate insecticides, the IC50 varied from 9.1 nM to 2,094 nM. For the novel carbamate insecticides, it varied from 58 nM to 388,800 nM. Based on IC50 data from previous work on A. …
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Severe Neurotoxicity Associated with supra-therapeutic Efavirenz concentrations: a retrospective cohort study
… often occurring early in therapy. Severe neurotoxicity has been reported but the clinical phenotype and risk factors are poorly defined. Methods We retrospectively identified adults with supratherapeutic efavirenz concentrations (> 4 mg/L) obtained as part of routine clinical care at five …
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Genetic polymorphisms and organophosphate neurotoxicity amongst emerging farmers in the Western Cape
… No previous study investigated XME modulation of neurotoxicity outcomes. OBJECTIVES: To investigate whether XMEs polymorphisms modulate OP neurotoxicity among emerging farmers. METHODS: A cross-sectional study of 301 emerging farmers was conducted in the rural Western Cape of South Africa. …
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Pesticides and Pesticide Mixtures Induce Neurotoxicity: Potentiation of Apoptosis and Oxidative Stress
Several epidemiological studies have suggested a role for environmental chemicals in the etiology of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Endosulfan (an organochlorine) and zineb (zinc-ethylene-bis-dithiocarbamate) are used as pesticides on a variety of …
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Effects of Ganglioside GM1 on MDMA-Induced Serotonergic Neurotoxicity in the Rat Brain
MDMA (Ecstasy), a methylamphetamine derivative, has been found to produce severe and somewhat selective damage to CNS serotonergic (5-HT) neurons. This damage, though extensive, does not involve cell death. The ganglioside GM 1 has demonstrated potential neurotrophic properties which may enhance …
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The enduring challenges of antiretroviral therapy. Focus on drug-related neurotoxicity and inflammation
Contains fulltext : 236306.pdf (Publisher’s version ) (Open Access)
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Programmed axon death as a driver of environmental neurotoxicity triggered by pyridine derivatives
… suggest that SARM1 mediates environmental neurotoxicity and contributes to toxic neuropathies induced by various molecules through different activation mechanisms, raising the question of whether other environmental chemicals or structurally similar drugs in use today also activate …
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Neonatal Hyperbilirubinemia: <i>in vivo</i> Characterization of Mechanisms of Bilirubin Neurotoxicity and Pharmacological Treatments
… explores three different aspects of bilirubin neurotoxicity: 1. The role of Bf in vivo by the administration of human serum albumin; 2. The events preceding death by a time-course analysis of mutant pups; 3. The investigation of the role of neuroinflammation by the administration of a …
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Development of mouse models of hydrogen sulfide-induced neurotoxicity for the evaluation of neuroprotective strategies
… as an antidote for treatment of H2S-induced neurotoxicity as it reduced H2S-induced mortality by 90% when given prior H2S exposure, and reduced mortality induced by H2S by 50% when given during the exposure. Midazolam administered pre-exposure prevented clinical signs, motor deficits, and …
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Relationship between pesticide residue levels and neurotoxicity among women on farms in the Western Cape
… pesticide residues in human body fluids and neurotoxicity. This study therefore aims to investigate the relationship between urinary pesticide residue levels and neurotoxicity amongst women working in farms in the Western Cape, South Africa.
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A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… used as an in vitro model for the study of the neurotoxicity of MPTP, including the mechanisms associated with exposure to this neurotoxicitant.
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