Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 201 for “"Neuroscience and Neurobiology"”.
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Running, Attention Restoration Theory and Environmental Compatibility.
… environments, most notably, nature, has been expanded beyond its current paradigm to incorporate activities, such as running (Norlinget al., 2008, 2010). This paper qualitatively explores the experience of running within the ART paradigm through pre- and post-intervention interviews with 18 …
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DISRUPTED GABA SIGNALING IN THE VENTRAL TEGMENTAL AREA DRIVES ADDICTION-LIKE BEHAVIORS
… are among the leading causes of premature death and disability. Most prominent among these, opioid misuse and dependence have become a devastating crisis. Despite this, a complete understanding of the neural circuit adaptations driving substance use disorders remains unknown.Animal models have …
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Neuroimaging Brain Changes Associated With Depression Treatment: A Meta-Analytic Informed Investigation
… psychiatry such as focusing on patient outcomes and using larger neuroimaging datasets. The present work explores these two different solutions to glean new insights into brain changes associated with depression treatment. First, coordinate based meta-analysis was utilized to search for brain …
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INTERNEURON TRANSPLANTS AS A TREATMENT FOR SEIZURES AND SOCIAL DEFICITS IN A MOUSE MODEL OF DRAVET SYNDROME
… have been shown to ameliorate seizures and epilepsy-associated behavioral deficits in several preclinical rodent models of epilepsy. These studies have generally focused on focal temporal epilepsy models, but less is understood about the efficacy of targeted interneuron transplants in …
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FEAR EXTINCTION AND INFRALIMBIC CORTEX IMPAIRMENT AFTER MILD TRAUMATIC BRAIN INJURY
… injury (TBI) is a leading cause of morbidity and disability, with mild TBI (concussions) representing over 80% of cases. Although often considered benign, mild TBI is associated with persistent neuropsychiatric conditions, including posttraumatic stress disorder, anxiety, and depression. A …
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CELL TYPE-SPECIFIC EFFECTS OF OPIOID DEPENDENCE ON CENTRAL AMYGDALA NEURONS
Opioid use disorder and chronic pain impact millions of Americans every year. Given the interactions of pain with opioid withdrawal, it is critical to understand how the neural substrates for pain, such as the central nucleus of the amygdala (CeA), are impacted by opioid dependence. Growing …
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IMAGING THE GLUTAMATERGIC SYSTEM WITH GLUCEST MRI: CYTOARCHITECTURE, AGING, AND INTERVENTION
… neurotransmitter in the mammalian brain and a key metabolic intermediate in neurons and astrocytes. Shifts in glutamatergic biology can both reflect and drive changes in circuit excitability, synaptic structure, glial function, and cellular metabolism, providing a mechanistic bridge from …
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Investigating circuit and spatial heterogeneity of human brain tumors with patient-derived organoid models
… prognosis. Both malignant cell heterogeneity and the influence of myriad cell types present in the tumor microenvironment, such as neurons, contribute to glioma progression. This dissertation represents a multi-pronged effort to unravel GBM heterogeneity by leveraging patient-derived GBM …
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A TALE OF TWO NEUREXINS: NRX-1 AND NLR-1 FACILITATE FUNCTION OF MONOAMINE CIRCUITS AND FORAGING BEHAVIORS
… (SAMs) have major roles in the structure and function of the neural circuits that control behavior. Alterations in neural circuits either from genetics or the environment can have major consequences on behavior and can be associated with conditions like autism spectrum and schizophrenia. …
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A central medullary circuit regulating REM sleep and pontine waves
… well as its theorized role in memory formation and consolidation. REM sleep is composed of tonic features such as hippocampal theta oscillations and skeletal muscle paralysis, which are interleaved with short-lived phasic events such as rapid eye movements, limb twitches, and spike-like pontine …
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Mechanisms Regulating Amyloid Processing Enzymes in HIV-Associated Neurotoxicity
… (HIV)-associated neurocognitive disorders (HAND), cognitive impairment seen in approximately 50% of HIV+ patients, shares similar pathological hallmarks with Alzheimer’s disease (AD). Extracellular plaques composed of amyloid-beta (Aβ), which are produced by cleavage of amyloid precursor …
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Striatal Control of Sensory-Driven Behavior and Its Relevance for Neuropsychiatric Disorders
… neuropsychiatric symptoms, including impulsivity and attentional deficits, making it critical to understand the underlying neural basis. In this study, we examined how the tail of the striatum (TS), a major sensory hub within the basal ganglia, regulates actions in response to sensory stimuli. …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… the regulation of hypothalamic hormones and has been implicated in various mood disorders such as depression. Preclinical and clinical data from studies in adults have shown that antidepressant drugs produce time-dependent changes in serotonergic and other systems and can also normalize …
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Morphometric characterization of individual sympathetic postganglionic axons innervating the muscle layers of the gastrointestinal tract of the rat: A complex effector model
… common assumptions about the morphology and distribution of catecholaminergic terminal fields have been strongly shaped by the limitations of the techniques employed to distinguish the fibers and complicated by inconsistent findings generated with various methodologies. Thus, the present …
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Microglia-Mediated Neuroprotection from Concussion
… impacts are highly prevalent in contact sports and are thought to increase concussion likelihood. However, we do not precisely understand the conditions under which subconcussive impacts affect concussion recovery, limiting both our mechanistic understanding and resultant recovery monitoring …
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THE ROLE OF INNERVATION IN ENGINEERED MUSCLE
… minor strains to devastating traumatic events, and represent a significant clinical challenge worldwide. Millions of individuals experience severe muscle deficits each year, including volumetric muscle loss (VML) resulting from ballistic trauma, blast injury, surgical resection, and accidental …
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Postmortem image analysis of the human brain to characterize Alzheimer's disease and related dementias
Alzheimer’s disease and related disorders are heterogeneous, age-related neurodegenerative diseases characterized by the co-occurrence of multiple pathologies that manifest themselves decades before a patient becomes symptomatic. Clinical trials have focused on preclinical stages of AD to detect …
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Single Cell Transcriptomics and Spatial Localization in Mouse Neurons
… cells whose primary functions are to send and receive electrochemical signals to and from other neurons in their connected network. Though their primary functions are similar, neurons are spatially and functionally specialized across a wide array of neuronal subtypes. Characterizing the …
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THE PROPHYLACTIC POTENTIAL OF DOCOSAHEXAENOIC ACID, AN OMEGA-3 FATTY ACID, IN TRAUMATIC BRAIN INJURY
… or even death. Given the unpredictable and heterogeneous nature of TBI symptoms along with the lack of a standard of care for TBI, there is interest in developing prophylactic strategies. Omega-3 fatty acids (ω3 FAs), known for their anti-inflammatory and neuroprotective benefits, are …
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Regulation and function of histone variant H2BE in neurons
… unit of the genome that organizes DNA and is made of four histone proteins: H2A, H2B, H3, and H4. Regulation of histone proteins affects gene expression through multiple mechanisms, including exchange with histone variants. While variants of H2A and H3 have well defined roles in …
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