Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 64 for “"Neuropsychiatry"”.
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Ready, Set, Action: Potential Breakthrough Therapy for Treatment-Resistant Depression
… as treatment-resistant depression. At Kadima Neuropsychiatry Institute, Dr. Feifel treats individuals with treatment-resistant depression with advanced treatments such as TMS and ketamine. During my fieldwork internship at Kadima Neuropsychiatry Institute, my project focused on evaluating the …
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A clinical audit of the management of ADHD in children and adolescents and comparison between two treatment sites in Cape Town
… the Red Cross War Memorial Children’s Hospital Neuropsychiatry Clinic. The 'peripheral’ group included cases from community clinics in Retreat, Vanguard, Heideveld, and Kensington. Fifty cases were randomly selected from each group. Data were captured using an audit template derived from NICE …
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Towards an evolutionary perspective of bipolar disorders: Is there a genetic link between bipolar disorders and non-pathological (adaptive) hyperactivity?
… Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) tool, which measures its pathological characteristics. According to the results regarding the investigated genetic variant (RS1006737) of the CACNA1C gene, an association was found with the characteristics of hyperactivity …
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Identification of natural TSC-Associated Neuropsychiatric Disorders (TAND) clusters
… cause the greatest burden of disease in TSC. The Neuropsychiatry Panel at the 2012 TSC Consensus Conference coined the term TAND (TSC-Associated Neuropsychiatric Disorders) to capture the multidimensional concerns seen in TSC, and recommended that each person with TSC should be screened for TAND …
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Screening for HIV-associated neurocognitive disorders in perinatally infected youth: Validation of the CAT-rapid version 2 screening tool
Objectives: There is a lack of locally validated cognitive screening tools for youth living with HIV. To test the validity of the Cognitive Assessment Tool Rapid v2 tool in screening for all forms of neurocognitive impairment in a sample of youth living with HIV in Cape Town, South Africa. Design: …
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An Evaluation of the Psychometric Properties of the Montreal Cognitive Assessment Tool when Administered in a Memory Clinic At Groote Schuur Hospital, Cape Town, South Africa
Worldwide, the population is aging, and the prevalence of neurocognitive disorders is expected to rise exponentially. Therefore, early detection of dementia is favorable for the patient and may even be of greater significance if disease-modifying treatments are discovered. The Montreal Cognitive …
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The Measure and Meaning of Structural Similarity in the Brain
… the brain and their translational relevance in neuropsychiatry and beyond.
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What makes us tic?
Published work 1971-2006, comprising 4 books, various articles, 2 review discussions on a videorecording, and supporting documents.
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White matter correlates of neuropsychological function in young adult methamphetamine users
Background: Methamphetamine (MA) abuse is a global health concern due to widespread use and harmful effects, which includes neurotoxicity. This study aimed to describe neurocognitive deficits associated with MA dependence in young adults and to explore whether these deficits correlate with white …
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The relationship between neurocognitive disorders, prospective memory impairment and white matter damage in clade C HIV-positive subjects
AIMS: To examine the relationship between prospective memory, cognitive function and Diffusion tensor imaging (DTI)/ White matter integrity of human immunodeficiency virus (HIV) positive individuals in the Western Cape. We hypothesize that: 1. Individuals infected with HIV will exhibit …
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Validation of the Mild Behavioral Impairment-Checklist in Subjective Cognitive Decline, Mild Cognitive Impairment and Dementia
Introduction: Neuropsychiatric symptoms (NPS) are early markers of dementia preceding cognitive impairment. The Mild Behavioral Impairment Checklist (MBI-C) was developed to characterize NPS for pre-dementia patients. This thesis examines the validity and utility of the MBI-C for detecting …
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Neurocognitive and Psychosocial Profiles of Pediatric Multiple Sclerosis and Transverse Myelitis
Research shows that youth with multiple sclerosis (MS) are at risk for neuropsychological deficits due to cerebral involvement, but establishing a clear profile remains difficult due to disease complexity. Emerging evidence also shows neuropsychological deficits and the possibility of brain-based …
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Response of sensorimotor pathways of the spinal cord to injury and experimental treatments
Many spinal cord injuries (SCI) are incomplete, variable numbers of spared fibres passing the lesion level and supporting some residual function below the injury. One approach to improving function following injury is to develop therapies that maximise the potential of these spared fibres. The aim …
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Analysis of nerve terminal dysfunction in autoimmune neuropathy
In studies on the pathophysiology of the autoimmune neuropathy, Miller Fisher syndrome (MFS), monoclonal antibodies to the disialosyl epitopes on GQ1b, GT1a and GD3 gangliosides have been produced. Antibodies to these complex gangliosides are thought to be crucial in the pathogenesis of MFS. These …
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The entrainment of brain oscillations through transcranial alternating current stimulation (tACS) delivered at off-peak frequencies.
It has been demonstrated that endogenous brain oscillations can become entrained to rhythmic stimulation. Four studies were conducted to investigate the possibility of modulating endogenous frequency peaks, through entrainment, from stimulation delivered at off-peak frequencies. Study 1 utilised …
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The effect of mindfulness movement therapy on arm and hand function in people with and without stroke
Upper extremity motor deficit is a big issue in patients with stroke. Mindfulness meditation may have potential to improve arm and hand function in stroke patients. However, there is no mindfulness programme specifically concerned with motor performance. Therefore, this thesis proposed a new …
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Characterisation of a recombinant human cysteine dioxygenase
Cysteine Dioxygenase is an enzyme that catalyses the reaction of cysteine to cysteinesulfinic acid and is thought to regulate the intracellular concentrations of its substrate. The enzyme may also be involved in the oxidation of exposed sulfidrils of protein and by implication, involved in cell …
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Electrophysiological characterization of a mouse deficient for oligophrenin1: a mouse model of X-linked mental retardation
Mental retardation is the most common brain disease. One of the first genes identified in X-linked mental retardation (XLMR) was the OPHN-1 gene. Mutation of this gene has been described in patients with moderate to severe cognitive impairments. MR is characterized by reduced cognitive function …
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From objects to action: a neuropsychological analysis
This thesis is concerned with the factors that determine the performance of everyday action. Six empirical chapters are subsequently presented. First, I sought to investigate the effects of the presence of distractors and of task load on the performance of everyday life tasks, comparing a patient …
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