Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 254 for “"Neuropsychiatric"”.
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Neuropsychiatric features of HIV/AIDS
The central hypothesis of this thesis was that HIV psychosis and mania are overlapping manifestations of the neuropathophysiological consequences of HIV characterized by symptoms suggestive of sub-acute delirium and cognitive impairment. It was also hypothesised that HIV-associated mania and …
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Pilot validation of the Tuberous Sclerosis Associated Neuropsychiatric Disorders (TAND) checklist as a screening tool for neuropsychiatric manifestations
Includes abstract. Includes bibliographical references.
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Identification of biological markers for neuropsychiatric disorders
Geriatric population is a rapidly growing segment of western communities. The need of management of this specifically vulnerable group of individuals has led to numerous studies concerning early detection of factors, which could be of importance for the course and prognosis of disorders in the …
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Transcriptomic and proteomic dysregulation in neuropsychiatric disorders
… human genome is involved in the development of neuropsychiatric disorders such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD), but the causal genomic molecular players remain unclear. Therefore, in this thesis, we evaluated disorder-associated disruptions …
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Exploring the role of Rapgef6 in neuropsychiatric disorders
Schizophrenia is highly heritable yet there are few confirmed, causal mutations. In human genetic studies, we discovered CNVs impacting RAPGEF6 and RAPGEF2. Behavioral analysis of a mouse modeling Rapgef6 deletion determined that amygdala function was the most impaired behavioral domain as measured …
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MicroRNA Dysregulation in Neuropsychiatric Disorders and Cognitive Dysfunction
… involvement of miRNAs in the development of neuropsychiatric disorders and cognitive dysfunction. In addition, the identification of key players in miRNA dysregulation has implications for both basic and translational research in psychiatric disorders and cognitive dysfunction.
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Identification of natural TSC-Associated Neuropsychiatric Disorders (TAND) clusters
… Conference coined the term TAND (TSC-Associated Neuropsychiatric Disorders) to capture the multidimensional concerns seen in TSC, and recommended that each person with TSC should be screened for TAND every year. To facilitate the process, a TAND Checklist was designed. Many professionals and …
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Neuropsychiatric symptoms in thymoma-associated and non-thymoma myasthenia gravis
… of thymoma may lead to other antibody-mediated neuropsychiatric manifestations including limbic encephalitis. We hypothesized that the prevalence of neuropsychiatric symptoms may be higher in MG subjects with thymoma-associated MG when compared with those who have non-thymoma MG. This study aims …
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Neuropsychiatric complications of efavirenz in children with HIV-1 infection
… Efavirenz is associated with transient neuropsychiatric manifestations but the impact on neurocognition is unknown. Genetically determined black South Africans who are slow metabolizers of efavirenz may be at risk of toxicity. This study describes neuropsychiatric and neurocognitive …
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Converging roles of neurodevelopment and Wnt signaling in neuropsychiatric disorders
Neuropsychiatric Disorders are the leading category contributing to disability-adjusted life years (DALYs) in the U.S. according to the World Health Organization. These findings underline the vast burden caused by neuropsychiatric disorders on patients. However, effective treatments do not exist …
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The development of intensive case work in a Veterans Neuropsychiatric Hospital.
Thesis (M.S.)--Boston University
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Mapping Molecular Changes in Human Neuropsychiatric Disorders to Zebrafish Behavioral Profiles
Despite decades of work, understanding the etiology of human psychiatric disorders has remained elusive. Recent advances in molecular profiling have allowed researchers to probe genetic and transcriptomic differences in post-mortem samples from individuals with healthy and diseased brains, which …
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A systems approach to determine how Toxoplasma gondii Infection causes neuropsychiatric disease
T. gondii infection acquired during life has been associated with psychoneurological disease in humans and behavioural changes in mice. However, less is known about the potential of congenitally acquired T. gondii infection, or for maternal T. gondii infection induced immune activation, to cause …
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Striatal Control of Sensory-Driven Behavior and Its Relevance for Neuropsychiatric Disorders
… this process are associated with a wide range of neuropsychiatric symptoms, including impulsivity and attentional deficits, making it critical to understand the underlying neural basis. In this study, we examined how the tail of the striatum (TS), a major sensory hub within the basal ganglia, …
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Lentiviral-mediated gene delivery to investigate the functional role of neuropsychiatric genes
… that may contribute to the risk of developing neuropsychiatric disorders. For example, dopamine receptor genes are established candidates for a number of psychiatric disorders such as Parkinson’s Disease, alcohol addiction and mood disorders. On the other hand, a gene of unknown function, AUTS2 …
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NOVEL APPROACHES TO MODELING AND TREATMENT OF COGNITIVE DEFICITS IN NEUROPSYCHIATRIC DISEASES
Kognitive Defizite und Beeinträchtigungen höherer Hirnfunktionen sind die meist belastenden Aspekte neuropsychiatrischer Erkrankungen (z.B. Elvevag & Goldberg, 2000). Bis jetzt existieren keine zufriedenstellenden Therapien zur Behandlung kognitiver Störungen bei neuropsychiatrischen Erkrankungen …
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School-Based Services for Children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
<p>Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) is an emerging disorder affecting school age children causing deleterious cognitive, social, emotional, and academic effects. Most frequently, children with PANS demonstrate severe, rapid-onset obsessive-compulsive symptoms in addition to a …
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Integration of common and rare genetic variation across complex traits and neuropsychiatric disorders
Research into the genetic basis of human disease has progressed rapidly over the past 20 years. Genome-wide association studies have identified thousands of links between common variants and phenotypic outcomes. More recently, whole exome and genome sequencing has catalogued patterns of ultra-rare …
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