Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Neuroprotective agents"”.
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Synthesis of Fluoroflavones as Potential Neuroprotective Agents
… natural products that are known to have neuroprotective effects against many diseases caused by the formation of reactive species. Flavonoids are subgroup of flavones and they are believed to function as antioxidants. Specifically, they target free radicals and eliminate its harmful …
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Progress Toward the Synthesis of 3-Methoxyflavones as Potential Antioxidants, Neuroprotective Agents, and Trifluoromethylated 19F NMR Probes
The total synthesis of polyhydroxylated flavones have proven to be challenging, due to the presence of more than one hydroxyl group. Direct cyclization was not successful in any of the attempts. However, by using a silyl protecting group, the cyclization was feasible. Other reactions like the …
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Histone deacetylase inhibitors as novel neuroprotective agents in in vitro and in vivo models of Parkinson’s disease
Histone deacetylases (HDAC) shift the balance towards chromatin condensation and silence gene expression. Aberrant recruitment of HDACs to alter transcription suggests the use of HDAC inhibitors (HDAC-Is) as potential therapeutic candidates for neurodegenerative disorders such as Parkinson’s …
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A combinatorial approach to the search for anticonvulsant agents from gou teng and tian ma
… thus the discovery of new antiepileptic agents is urgently needed. Gou Teng and Tian Ma are two famous Traditional Chinese Medicines (TCMs) widely used in the treatment of epilepsy. Some oxindole alkaloids of Gou Teng have been shown to be antagonists of NMDA receptor, possibly …
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The Effects of Ethynodiol Diacetate on Epinephrine-Treated Glial-Derived Cells
<p>Neuroprotective agents, including specific hormones, may play a role in preventing cellular damage following an ischemic event or brain injury. Astrocytes are specialized glial cells within the central nervous system that play roles in synapse development, blood flow regulation, extracellular …
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Electrophysiological biomarkers in genetic movement disorders
… Treatment remains symptomatic. Development of neuroprotective agents has been hampered for various reasons. This includes the inability of making the diagnosis accurately early in the course and the lack of reliable disease progression markers which could be used in future treatment trials. …
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Glial Changes and Role of Connexin43 in a Laser-induced Rodent Model of Retrobulbar Optic europathy
… the injury and to facilitate development of neuroprotective agents. Methods: Rats (200-250g) were first anaesthetised via intraperitoneal approach with a mixture of Xylazine and Ketamine. An incision was made through superior conjunctiva and Tenon’s capsule and orbital portion of the optic …
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Development of P7C3-Class of Neuroprotective Molecules
… I describe the development of the P7C3-series of neuroprotective compounds, which were originally discovered through an unbiased in-vivo screen for new chemicals with proneurogenic and/or neuroprotective properties. My dissertation work focused on evaluating the efficacy of these compounds in …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… protective effects and mechanisms of two novel agents Gly<sup>14</sup> humanin (HNG) and necrostatin-1 (Nec-1) were examined. HNG, a highly potent neuropeptide against amyloid toxicity, exhibited anti-apoptotic properties on cerebral ischemia injury. HNG reduced infarct volume after …
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Development of Polymeric Nanoparticles Containing a Natural Antioxidant (α-Tocopherol) for the Treatment of Spinal Cord Injury
… of SCI includes the delivery of high doses of neuroprotective agents which have not been proven to be effective. The challenge in therapy is to deliver low and effective doses of therapeutics to ameliorate the injury condition. Thus, this study focuses on developing nanoparticles (NP) loaded …
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Development of intranasal therapeutic nanoparticles for the treatment of neurological disorders
… victims receive medical attention. Numerous neuroprotective agents, such as peptides, hormones, and siRNA, have been shown to confer neuroprotection following ischemic stroke in animal models. Clinically, treatment of ischemic stroke is hindered by the relative isolation of the central …
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Synthesis and biological studies of a fullerene-Taxol conjugate and fullerene-based transfection vectors
… a variety of medical applications, which include neuroprotective agents, HIV-1 protease inhibitors, photosensitizers for photodynamic therapy, MRI contrast agents, and radiopharmaceuticals. The first part of this work is dedicated to the development of a new application of C60 as a slow-release …
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DESIGN, SYNTHESIS AND BIOLOGICAL PROFILING OF NEW COMPOUNDS: INFECTIOUS AND NEURODEGENERATIVE DISEASES AS TARGETS
… the synthesis and characterization of innovative neuroprotective compounds aimed at combatting the devastating neuropathologies stemming from misfolded proteins. This ambitious endeavor commenced with a meticulous exploration of Proteolysis Targeting Chimera (PROTAC) technology as a promising …
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Phytochemical, anti-cancer, anti-inflammatory and neuroprotective studies on compounds isolated from Malaysian plants, Aquilaria malaccensis and Hopea dryobalanoides
… such as anticancer, anti-inflammatory and neuroprotective effects. This thesis aimed to : 1) isolate bioactive compounds from two Malaysian plants which are: Aquilaria malaccensis and Hopea dryobalanoides using column chromatography and characterised them by nuclear magnetic resonance …
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Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection
This study focused on the synthesis of a series of novel tricycloundecane derivatives and evaluation of these compounds for neuroprotection using the fluorescent ratiometric calcium assay that indicates the ability of the test compounds to inhibit NMDA receptors and VGCC. The cycloaddition reaction …
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Therapeutic Modalities Targeting Neuroinflammation After Neonatal Hypoxia-Ischemia
… responsible for both neurodestructive as well as neuroprotective outcomes. Herein, we tested the hypothesis that COX-2 mediates mechanisms of brain injury and that G-CSF exerts structural and functional protection after neonatal HI.</p> <p>To mimic the clinical features of HI brain injury, …
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Mechanisms of Neonatal Brain Injury in a Rat Pup Hypoxic-Ischemic Model
<p>Perinatal hypoxic-ischemic (HI) brain injury is a major cause of acute morbidity and chronic nemological mortality in infants and children, with a reported incidence of 2- 9 per 1000 births. The pathophyiological mechanisms leading to immature brain damage after HI are complex and relate to the …
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Crotalus Snake Venom Preconditioning to Prevent Surgical Brain Injury
<p>Preventive measures are increasingly relevant to medical practice. Preconditioning, a preemptive therapy that administers mildly harmful stimuli to induce endogenous protective mechanisms before major injury, has been shown to minimize injury in many animal models. Given the elective nature of …
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MAPK and pro-inflammatory mediators in the walls of brain blood vessels following cerebral ischemia
… and have therefore become a prime target for neuroprotective treatments [13-15]. A number of neurochemical and pathophysiological events are triggered within the ischemic penumbra. As a result of energy depletion, there is disruption of ion homoeostasis, excessive release of excitatory …