Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Neuroprotective action"”.
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Molecular mechanism of Abeta recognition and neuroprotection by the glycoconjugate beta-sheet-breaker peptide Ac-LPFFD-Th
… mechanisms underlying the antifibrillogenic and neuroprotective action exhibited by a new class of trehalose conjugated pentapeptides. Trehalose (Th), a non-reducing disaccharide of alpha-(D)glucose, has been demonstrated to be effective in preventing the aggregation of several proteins. We …
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Investigations into the Neuroprotective Effects of Osteopontin in In Vitro and In Vivo Models of Parkinsons Disease
… of PD. This effect may be mediated through interactions between the RGD binding domain of OPN and integrin receptors resulting in an attenuation of reactive gliosis and the production glial-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF). Therefore, the aim of …
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Cellular Effects of Cerebral Ischaemia In Vitro’. Cerebroprotective Actions of GABAmimetic agents
… in the glutamate efflux and also to study the actions of selected GABAmimetics in order to explain why some GABAmimetic agents are neuroprotective but others are not. In parallel electrophysiological studies, the actions of clomethiazole were analysed further. Incubating rat cortical prisms in …
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Studies on Bioactive Lipid Mediators Involved in Brain Function and Neurodegenerative Disorders. The effect of ¿-3PUFA supplementation and lithium treatment on rat brain sphingomyelin species and endocannabinoids formation; changes in oxysterol profiles in blood of ALS patients and animal models of ALS.
… EPA and DPA are thought to exhibit a range of neuroprotective effects many of which are mediated through production of such lipid mediators. The aims of this study were to evaluate the effects of n-3 EPA and n-3 DPA supplementation on RBC membranes and in this way assess dietary compliance and …
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Non-invasive drug delivery to the posterior segment of the eye: Development of formulation strategies and evaluation of ocular distribution and pharmacological activity
… model, HT levels were maintained above the neuroprotective and antiinflammatory IC50 levels for upto 6 h. We also prepared HT loaded (0.1% w/v) solid lipid nanoparticles (SLN’s) using a combination of 85% glyceryl monostereate and 15% compritol ATO 888. The particle size, zeta potential and …
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The effect of eicosapentaenoic acid on brain and platelet produced bioactive lipid mediators. The effect of eicosapentaenoic acid, docosapentaenoic acid and other polyunsaturated fatty acids on the eicosanoids and endocannabinoids produced by rat brain and human platelets using electrospray ionisation tandem mass spectrometry-based analysis.
… is a polyunsaturated fatty acid (PUFA) with neuroprotective and cardioprotective properties. It is thought that some of the actions of EPA may be attributed to its elongated metabolite, the PUFA docosapentaenoic acid (DPA). Docosahexaenoic acid (DHA) and arachidonic acid (AA) are bioactive …