Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 310 for “"Neuroprotective"”.
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Development of P7C3-Class of Neuroprotective Molecules
… I describe the development of the P7C3-series of neuroprotective compounds, which were originally discovered through an unbiased in-vivo screen for new chemicals with proneurogenic and/or neuroprotective properties. My dissertation work focused on evaluating the efficacy of these compounds in …
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Synthesis of Fluoroflavones as Potential Neuroprotective Agents
… natural products that are known to have neuroprotective effects against many diseases caused by the formation of reactive species. Flavonoids are subgroup of flavones and they are believed to function as antioxidants. Specifically, they target free radicals and eliminate its harmful …
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Neuroprotective Effects of FGF20 on Dopamine Neurones
… fibroblast growth factor-20 (FGF20) to have neuroprotective effects on dopamine neurones in vitro. In this thesis, FGF20’s neuroprotective effects on dopamine neurones were further investigated. A ventral mesencephalic (VM) embryonic dopamine neurone culture system and a partially lesioned …
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Facilitating Healthy Ageing: Neuroprotective Effects of Mindfulness Practice
Mindfulness-based meditation practices involve various attentional skills including the ability to sustain and focus ones attention. During a simple mindfulness based breath awareness meditation, sustained attention is required to maintain focus on the breath while meta-cognitive awareness and …
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Defining a Neuroprotective Pathway for the Treatment of Ataxias
Spinocerebellar Ataxias (SCAs) are a group of genetic diseases characterized by progressive ataxia caused by neurodegeneration of specific cell types, namely Purkinje Cells (PCs) of the cerebellum. Mouse models of SCA Type 1 (SCA1) can be used to study the molecular mechanisms underlying PC …
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Alcohol/HIV-Induced Neurodeficit and Circumvention by Neuroprotective Agent
… out a three-pronged study to demonstrate the neuroprotective properties of PPAR γ agonist, Rosiglitazone. We investigate the efficacy of this treatment using an animal study, and further investigate the effects on receptors and cytokines. We also evaluate the type of drug effect rosiglitazone …
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
… 2 (Nrf2) and how these pathways might influence neuroprotective abilities of SFN. Basal assessments confirmed that SFN can induce Nrf2-driven phase II enzymes, as determined by qPCR as well as immunoblotting. The elevation of the main autophagy marker light chain 3-II (LC3-II) by SFN could be …
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NEUROPROTECTIVE THERAPIES CENTRED ON POST-TRANSLATIONAL MODIFICATIONS BY SUMOYLATION
Ischemic stroke poses a massive burden of disease and continues to be a leading cause of morbidity and mortality throughout the world. However, beyond thrombolysis/mechanical thrombectomy we possess few effective therapies that are able to modulate the pathogenesis of evolving ischemic brain …
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A Neuroprotective Role for Mir-1017, a Non-Canonical Mirna
<p>miRNAs are post-transcriptional regulators of gene expression, with numerous being involved in neurobiology. Within the human genome a quarter of the identified miRNA loci derive from a class of miRNAs termed tailed mirtrons. Despite the identification of this large population of miRNA, no …
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Investigating the protein targets of the neuroprotective E3 ligase, CHIP
… phenotype seen in CHIP KO mice support its neuroprotective effects, but the underpinning molecular mechanisms remain largely unknown and understudied. This project aimed to identify the protein targets of CHIP in a neuronal cell model of disease. I knocked out CHIP expression using …
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Rapid neuronal responses during spreading neurotoxic and neuroprotective network activity
… (small beads). We determine that a network neuroprotective capacity exists that limits spreading toxicity, which may be recruited from a distal site even after an excitotoxic insult has occurred. Together, we may have identified a new therapeutic opportunity to limit on-going brain damage in …
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Hydrogen Sulfide in Glaucoma: Delivery System, Hypotensive and Neuroprotective Effects
… further decreased the IOP by 32.3%. Lastly, the neuroprotective effects of H2S on the bovine retina were evaluated with H&E, TUNEL, glutathione, and superoxide dismutase assays. The biochemical assays reveal the ability of H2S to protect RGCs from oxidative stress-induced damage, attenuate …
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Synthetic Investigations towards the Total Synthesis of Neuroprotective Natural Products
… work undertaken towards the synthesis of the neuroprotective natural products mescengricin (12), palmyrolide A (13) and sanctolide A (14). Investigations towards the synthesis of mescengricin (12) were initially directed towards cyclisation of diarylamines 175. Attempts were made to elaborate …
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Neuroprotective Functions of Docosahexaenoic Acid and Epidermal Fatty Acid Binding Protein
<p>Lipotoxicity (LTx) is involved in mostly every process of neuronal injury. Using NGFDPC12 cells we show that palmitic acid (PA) induces the expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. …
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Neuroprotective effects of PACAP, VIP and NAP against hyperglycaemic retinal damage
Diabetic retinopathy, one the most significant and disabling chronic complications of diabetes mellitus, has mainly been regarded as a microcirculatory disease of the retina. However, there is emerging evidence to suggest that a primary and early neurodegenerative process characterizes DR. The …
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NEUROPROTECTIVE STUDIES ON THE MPTP AND SOD1 MOUSE MODELS OF NEURODEGENERATIVE DISEASES
… treatments and determination of their neuroprotective mechanism (target validation). Taken together, ideal candidates for the treatment of neurodegenerative disease would need to exert their neuroprotective effect on multiple pathological pathways. Previous studies from this laboratory …
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Design and Synthesis of a Novel Neuroprotective Brain-Targeting Amylin Receptor Antagonist
… this study is to design and synthesize a novel neuroprotective analog of AC253 called R16 for enhanced blood-brain barrier targeting. R16 was synthesized using solid-phase peptide synthesis, purified and characterized by MALDI-TOF mass spectrometry and reversed-phase HPLC. The proteolytic …
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Synthesis of novel vanillin derivatives: study of their antioxidant and potential neuroprotective properties.
… properties and to study their potential neuroprotective activities in oxidative stress models in vitro. To achieve this aim, novel vanillin derivatives were synthesised through a reductive amination reaction, by reacting vanillin with a selection of amines. All the derivatives were …
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… and clinical translation. In the development of neuroprotective strategies and translation of experimental results in HIE, there are many limitations and challenges to master based on an appropriate study design, drug delivery properties, dosage, and use in neonates. Since there are no …
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