Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 234 for “"Neuropeptide"”.
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Neuropeptide FF and Neuropeptide VF and their control in the regulation of energy homeostasis and glucose metabolism
… pathway tracing to investigate the role of the Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) in the regulation of energy balance and glucose homeostasis. This study reveals that NPFF signalling plays important roles in fluid and glucose homeostasis, since Npff-/- mice exhibit an increased …
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Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
… (GPCR) for the recently identified ligands neuropeptide B (NPB) and neuropeptide W (NPW), was found to be specifically down-regulated after GTG treatment. The physiological role of GPR7 was investigated by generating and analyzing mice with targeted disruption of GPR7. Male GPR7-/- mice …
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Effects of Neuropeptide Y on Adipocyte Metabolism
Recently, we have shown that neuropeptide Y (NPY) is produced and upregulated in visceral adipose tissue of an early-life programmed rat model of central obesity. Moreover, we have demonstrated that NPY contributes to the pathogenesis of obesity. However, the role of NPY in regulating adipocyte …
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Bioinformatics and Mass Spectrometry for Neuropeptide Characterization
The methods employed for the discovery of neuropeptide genes and gene products in insect, echinoderms and chordates along with neuropeptide processing predictors present generalized and successful approaches for neuropeptide discovery in any organism.
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Neuropeptide hormones from the eyestalks of Jasus Lalandii
… are known to be a source of a variety of neuropeptide hormones that regulate a number of diverse physiological processes. This neuroendocrine complex was investigated in 3 crustacean species, viz. the European shore crab Carcinus maellas, and 2 spiny lobster species Jasus lalandii and …
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Hexamerine und Neuropeptide in der postembryonalen Entwicklung der Insekten
… Insekten eingreifen. Hexamerine und Neuropeptide besitzen sehr unterschiedliche Funktionen. Während Neuropeptide zusammen mit anderen Gewebshormonen auf einer übergeordneten regulatorischen Ebene wirken, sind Hexamerine als Speicher- und Verteidigungsproteine ein Endglied dieser …
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Satiety induced by neuropeptide FF and gastrin in birds
… was to determine how two satiety-inducing neuropeptides regulate feeding behavior in avian models. Neuropeptide FF (NPFF) was intracerebroventricularly (ICV) injected into Japanese quail and decreased food intake at a dose of 32 nmol. NPFF-injected quail had increased expression levels of …
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Preliminary characterisation of the neuropeptide melanin concentrating hormone in humans
… concentrating hormone (MCH) is an orexigenic neuropeptide expressed centrally in the zona incerta and lateral hypothalamus. Evidence from rodent studies implicates hypothalamic MCH in the modulation of varied and diverse physiological functions most notably in energy homeostasis but also …
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Systems based approaches to unravelling neuropeptide-receptor interactions in nematodes
… of novel drug targets in these worms. Neuropeptide G protein-coupled receptors (NP-GPCRs) are an appealing anthelmintic target, however, a lack of knowledge on the profiles and functions of neuropeptide ligands and receptors in nematode parasites currently limits their exploitation. …
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Folding, dynamics and interaction studies of the Neuropeptide Y family.
… advance the treatment of human disease. The Neuropeptide Y family of peptides are highly conserved peptides found in nature, consist of 36 amino acids, and are widely distributed in the central nervous system of mammals. A detailed study of thermodynamics, kinetics, membrane translocation, …
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Liquid chromatography-mass spectrometry-based neuropeptide characterizations across neuronal models
Neuropeptides, as one largest category of cell-to-cell signaling molecules, play a regulatory role in a range of physiological and behavioral functions within an organism, such as reproduction, feeding, metabolism regulation, learning and memory. They act as neurotransmitters,neuromodulators, …
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Exploring relationships between stress and olfaction as mediated by neuropeptide y
… and resilience to stress, specifically examining neuropeptide y (NPY) as a mediator. In phase I, 197 UTC students participated in a survey measuring stress and resilience among other factors. Of this sample, 25 students volunteered for phase II, in which they took an olfactory threshold test and …
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The Neuropeptide Regulation of Host-Seeking Behavior in Aedes Aegypti Mosquitoes
… studies identified Head Peptide-I as a candidate neuropeptide modulating this suppression in host-seeking behavior. This conclusion was strengthened by the observation that Head Peptide-I injection into non-blood-fed females triggered the inhibition of host-seeking. The mechanism by which this …
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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE
… ASICs, I also studied mechanisms of ASIC1a neuropeptide modulation. Modulation of ASIC can potentiate or inhibit its activity and therefore may affect physiological and pathological roles of ASIC. Yet, the mechanism of peptide modulation of ASIC is unknown. I have discovered a potential …
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Design synthesis and biological evaluation of non-peptide neuropeptide FF ligands
Neuropeptide FF is an endogenous RF-amide with two receptor subtypes originally described as having anti-opioid characteristics. While peptide work helped to elucidate key features for targeting the subtypes of the neuropeptide FF receptor, non-peptide small molecules offer a more refined tool to …
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Molecular and Genetic Analysis of Neuropeptide Signalling in Mammalian Circadian Timekeeping
… Vasoactive intestinal peptide (VIP), a neuropeptide expressed in the retinorecipient ventrolateral region of the SCN, is vital to this circuit-level co-ordination by signalling to its cognate VPAC2 receptor. In addition, VIP is important for the integration of light input into the SCN …
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The Role of Neuropeptide Y Y1R in Skeletal Muscle Lipid Metabolism
The Hulver laboratory has recently found that the neuropeptide Y Y1 receptor (NPY Y1R) mRNA expression is elevated in skeletal muscle of obese humans (Hulver, unpublished). The goal of this research is to study the role of the NPY Y1R in skeletal muscle lipid metabolism. Rat L6, mouse C2C12, and …
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Following Neuropeptide Processing, Distribution, Transport, and Release Using Novel Mass Spectrometric Approaches
Using these strategies and the improved sampling protocols, a large number of novel peptides have been discovered in molluscan and other invertebrate model systems. The utility of MALDI-MS has grown from simple molecular-weight profiling to elegant experiments that enable the discovery and …
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