Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Neuronal toxicity"”.
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Neuronal Toxicity of Humoral Factors From Patients With Diabetic Neuropathy and Mechanism of Neuronal Death on Cultured Adrenergic Neurons: Studies of Autoimmune Pathogenesis in Diabetic Neuropathy
… 1993; 1995). Some sera were cytotoxic and caused neuronal death. Further characterization of the inhibiting, or toxic, factor in IDDM patient serum indicated that it had the properties of an immunoglobulin. The toxic factor was present in the immunoglobulin fraction, and was pre-absorbed by …
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Cholinesterase Inhibitors and Neuropathology of Cerebrovascular Disease and Other Dementias in Patients with Alzheimer’s Disease: A Study of NACC Autopsy and Medical History Data, 2005 – 2017
… inhibitors suggested protective effects against neuronal toxicity from multiple sources. Investigations in primates found ChEI restored cerebral blood flow. Work in animals suggests ChEI may have a neuroprotective effect, though not necessarily impacting pathologies associated with Alzheimer’s …
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Using cannabidiol and trazodone to treat protein misfolding neurodegenerative disease in C. elegans
… behavioral deficits, glial inflammation, and neuronal toxicity. Laboratory animals, which have long been used to study this disease, have been genetically modified to express the two aforementioned proteins and express similar deleterious effects. However, despite the individual targeting of …
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Identification of novel palmitoyl acyl transferases and characterization of the role of Huntingtin palmitoylation in Huntington Disease
… The importance of the finding that HIP14 is a neuronal palmitoyl transferase is further emphasized by our recent discovery that huntingtin protein folding, trafficking and function are regulated by the enzyme HIP14. Expansion of the polyglutamine tract in huntingtin as seen in Huntington …
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Retroviral envelope glycoproteins: mediators of neuropathology in nervous system development and neurodegeneration in HIV-1 infection
… HIV-1, the causative organism of AIDS, produces neuronal death as a primary viral effect in many AIDS cases, and it does so even though the virus does not infect neurons. The search for the pathomechanisms by which HIV-1 causes neurologic disease has frequently focused on the possible role of the …
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Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
… cytokine that has been identified in directing neuronal response to disease or injury. Results are conflicting as to the role of TNF in mediating neuronal injury. TNF can protect neurons from excitotoxic and metabolic injury but can also mediate neuronal toxicity. We hypothesize that cell state …
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Effects Of Altering The Peroxisomal Redox State In Models Of Degenerative Disease
… Alzheimer's disease, β-amyloid peptide-induced neuronal toxicity is significantly reduced.</p>
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Direct neuronal and microglia-mediated effects of group I metabotropic glutamate receptors in neurodegenerative and neuroinflammatory processes
… were transferred onto neurons, they increased neuronal toxicity induced by rotenone. Among possible factors released by MVs, in preliminary studies, we have identified miRNA146a as a potential mediator of this effect. At the same time, the other member of group I mGlu receptor, mGlu1 receptor, …
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Studies on transient receptor potential vanilloid subtype 1 (TRPV1)-mediated degeneration of mesencephalic cellsin vivo and in vitro
… system (CNS). However, little is known about toxicity via TRPV1 in the SN. Intranigral injection of the TRPV1 agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by …
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Structural Properties of α-Synuclein in Functional and Pathological Contexts
… by αS oligomers resulting in the generation of neuronal toxicity in PD (Chapter V). Indeed, while fibrillar aggregates of αS represent the major histopathological hallmarks of PD, small oligomeric assemblies of this protein are believed to play a crucial role in neuronal impairment. We obtained …