Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Neuronal processes"”.
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Network activity arising from optimal diameters of neuronal processes
Electrical coupling provides an important pathway for signal transmission between neurons. In several regions of the mammalian brain electrical synapses have been detected, and their role in the synchronization of neural networks and the generation of oscillations has been studied theoretically. …
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Neuronal Processes Underlying Spatial Summation of Heat Sensations Investigated by Functional Magnetic Resonance Imaging of the Entire Central Nervous System
… area is increased. This project investigated the neuronal processes underlying spatial summation of heat sensations in healthy female volunteers, by means of functional magnetic resonance imaging (fMRI) of the central nervous system. The first study of this project involved increasing the surface …
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A multi-photon microscope for three dimensional functional recording of fast neuronal activity
… limitations complicate any attempt to study neuronal function with sub-cellular resolution: First, neurons and neuronal processes are small, second, in realistic experimental situations they can be located deep within optically scattering tissue, third, the chemical and electrical signaling …
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Regulation of Memory by the Actin-Binding Protein Cofilin
… impairments are often correlated with altered neuronal structure or function. Therefore, understanding the molecular mechanisms is important to better understand neurodevelopmental disorders. One process that is important for neuronal development is remodeling of the actin cytoskeleton. This …
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Illuminating the mental memoriam
… cells active during these discrete mnemonic processes can be identified and manipulated at rapid timescales. Here, I begin with historical studies that lead to the modem memory engram theory. Then, I present our recent advances in memory research that combine transgenic and optogenetic …
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Transcranial alternating current stimulation to areas associated with the human mirror neuron system reveals modulation to mu-suppression and corresponding behaviour
… related activity. The hMNS is characterized by neuronal activity that responds to both action observation and execution of the same movement. This activity has been directly observed in both macaque monkeys and in humans. There is an abundance of studies using indirect measures of neuronal …
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The Roles of daf-6 and Cell-Cell Interactions in Sensory Organ Morphogenesis
… The genetic regulation of these morphogenetic processes is poorly understood. As a model for organ morphogenesis, I studied the development of the Caenorhabditis elegans amphid sensory organ. Sensory organs in diverse species are often composed of neuronal sensory endings accommodated in a …
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Neural Correlates of Inter-Individual Differences in Pain Processing Investigated by Functional Magnetic Resonance Imaging of the Entire Central Nervous System
… will contribute to a better understanding of the neuronal processes, as well as substantial inter-individual variability observed in chronic neuropathic pain populations such as fibromyalgia, patients with spinal cord injuries etc.
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The Role of Neuronal Leak Channels in Anesthesia
… potassium (K2P) leakchannels that establish the neuronal resting membrane potential (RMP). Usingthe nematode, C. elegans, I tested the effect on anesthetic sensitivity ofcombining these potassium and sodium leak channel mutations in a singleanimal. I also used the light activated proteins, …
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Analyzing peptide release using mass spectrometry
… and hormones that impact a large variety of neuronal processes. The term neuropeptide refers to bioactive peptides made in neuron, stored in vesicles, and released into the extracellular space. While many peptides can be detected in a tissue homogenate, these will include processing …
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The pathogenesis of murine retroviral-induced noninflammatory spongiform polioencephalomyelopathy: Neuronal degeneration is indirectly mediated by resident microglial cells
… CNS spongiform lesions originated from both neuronal and oligodendroglial degeneration as a result of dilation of the cytocavitary system of proximal neuronal processes and vacuolization of myelin sheaths, respectively. When compared to wt MoMuLV, the neurovirulence of ts1 MoMuLV occurred by …
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Modulating System xc- Activity As A Treatment For Epilepsy
… However, current therapeutics designed to modify neuronal processes, provide no relief to 1-in-3 epileptic patients. Additionally, no disease modifying therapies currently exist to treat the underlying pathological processes involved in epileptogenesis. The overarching goal of this project is to …
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Nano-based drug delivery systems: Targeting to corticospinal tract neurons for controlled release of therapeutics
… motor neurons, and promotion of outgrowth of neuronal processes from release of the outgrowth promoting therapeutic, C3 transferase. Each SFNP construct stably bound between 68.2 and 74.7% of the initial amount of BDNF. About 40.7% of the N150 and 42% of C150 SFNPs either not derizatized or …
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Prenylation-independent activation of RhoA and Rac1: Effects on localization and neurite outgrowth
… of focal adhesions, retraction of neuron processes in response to injury or insult and growth cone collapse. Rac1, another Rho GTPase, is implicated in regulating cell proliferation, cell cycle entry, and extension of neuronal processes. Both RhoA and Rac1 require prenylation for membrane …
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Analisi dei profili di espressione dei microRNA: identificazione di biomarker nel suicidio
… pattern are associated with several pathological processes. In particular, post-mortem brain studies support miRNA involvement in the pathophysiology of psychiatric disorders but their role as peripheral biomarkers or targets of pharmacological treatments has been scarcely investigated. Our …
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Analytical applications of nanostructured plasmonic crystals
… crystal surface, and the thicknesses of neuronal processes were quantitated using the calibrations derived for this reflection imaging protocol using common laboratory equipment: a reflection microscope, commercially available bandpass filters, and a digital camera. The imaging-based …
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Lysosomes and Ribonucleoprotein Dynamics in Neurons
… the critical role for this organelle in neuronal function and homeostasis. However, little is known about why diseases that impair this ubiquitous organelle often give rise to neuron-specific deficits. Given the selective vulnerability of neurons to lysosomal dysfunction, a better …
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The Transcriptional Profile of Microglia: From Brain to Dish
… expression in primary cells can be linked to neuronal processes such as CNS myelination. Data from the third chapter of this thesis identified the CNS environment as a major stimulating factor in the gene expression profile of primary microglia. Therefore, I used single cell analysis to …
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Visualisation of dynein complexes in vitro and inside cells
Proper neuronal function relies on efficient transport within axons and dendrites, the long processes which extend from neuronal cell bodies. Within neuronal processes, the microtubule cytoskeleton provides tracks for motors to carry cargo over long distances. In axons, cytoplasmic dynein-1 …
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Mechanism of mRNA localisation and posttranscriptional modification in Drosophila melanogaster embryonic neurons
In recent years it has become apparent that neuronal development and function relies not just on the regulation of transcription but also on post-transcriptional events. Two prevalent mRNA-based regulatory mechanisms in neurons are asymmetric mRNA localisation and the generation of different 3’UTR …
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