Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 74 for “"Neuronal development"”.
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Endogenous neurosteroid actions at GABAA receptors during neuronal development
… inhibition in the CNS and as such are crucial to neuronal function. Two distinct modes of GABAAR mediated inhibition exist: “phasic” involves the transient activation of postsynaptic GABAARs following presynaptic vesicular GABA release and “tonic” whereby high-affinity extrasynaptic GABAARs are …
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The Role of Edc3 in Drosophila Melanogaster Neuronal Development
… disability (ID), however, the role of Edc3 is neuronal development has never been evaluated. Here, we use the <em>Drosophila melanogaster</em> model system to investigate the effects of Edc3 disruption on neuronal development. We found Edc3 reduction leads to significant hyperplasia at the …
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The Role of Vps54 in Drosophila melanogaster Neuronal Development and Age Progressive Neurodegeneration
… understand the role of Vps54 in motor neuron development, function, and age-related neurodegeneration, we disrupted expression of the Vps54 ortholog in Drosophila and examined the impact on larval neuromuscular junction morphology, locomotor function, and longevity. We show that functional …
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The role of the extracellular matrix in neuronal development and perinatal brain injury
… of ECM structures around neurons, termed perineuronal nets (PNNs). Although HA and PNNs are important for neuronal function in the mature brain, the specific expression and functions of HA and PNNs in the developing CNS under physiological and pathophysiological conditions remain largely …
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Concentration-dependent Splicing through Suboptimal Motifs Enables Waves of Gene Regulation in Neuronal Development
… regulates alternative splicing during animal development and in disease, impacting thousands of exons in the maturing brain, heart, and muscle. Although it is well established that Rbfox binds to the RNA sequence GCAUG with high affinity and specificity, this motif is responsible for only half …
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Characterisation of the role of brain factor 1 in the olfactory neuroepithelium during neuronal development
… playing a critical function in the regulation of neuronal progenitor cell proliferation and differentiation within the developing forebrain. The molecular mechanisms by which BF-1 carries out its function remain to be elucidated. Hence, this study aimed to investigate and characterise the …
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Requirement of Baboon/dsmad2-Mediated Tgf-Beta/activin Signaling for Post-Mitotic Neuronal Development in the Drosophila Brain
… neurons during metamorphosis contributes to the development of the Drosophila adult brain. This study provides evidence for cell-autonomous involvement of widespread Baboon/dSmad2-mediated TGF-beta/Activin signaling in various neuronal developmental processes prior to the prepupal ecdysone peak. …
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The OP27 cell line as a model system to study the effects of FGF-2 in olfactory neuronal development
… the main focus in this study was its effect on neuronal differentiation.
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Human Neuroblastoma, Strain Sk-N-Sh, as a Model System of Nerve Cell Differentiation: Neuronal Development, Plasminogen Activator Release, and Unscheduled Deoxyribonucleic Acid Synthesis
This study characterized morphological and biochemical properties of the cultured human neuroblastoma, strain SK-N-SH, maintained in vitro. In complete growth medium supplemented with 15% fetal bovine serum, SK-N-SH cells exhibited a large nucleus, with several distinct nucleoli, and neurite- and …
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Converging biochemical pathways in psychiatric disorders
… burden, there is a lack of new treatments under development: approved treatments all essentially target the same target(s), if the target itself is known. There is now considerable evidence for a common set of heritable risk for psychiatric disorders including schizophrenia, bipolar disorder, as …
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The growth-arrest-specific protein gas7 potentiates neuronal differentiation
… gas7 protein is involved in neuronal development. Its role in neuronal differentiation and its potential neuroprotective activity were investigated in PC 12 and NT2 cells. gas7 overexpression in PC12 cells promoted neurite outgrowth and potentiated nerve growth factor-induced …
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Biochemical and Genetic Studies of Beclin 1 Function in Autophagy
… autophagy protein and has important functions in development, tumor suppression and neurodegeneration. Beclin 1 exists in a protein complex with Vps34, which is a class III phosphatidylinositol (PtdIns) 3-kinase and mediates multiple vesicle trafficking pathways including autophagy and …
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ELUCIDATING THE ROLE OF BCAT1 IN MITOCHONDRIAL FUNCTION AND NEURODEVELOPMENT
… and immune cell function, the role of BCAT1 in neuronal development and mitochondrial function remains elusive. Further, while recent findings link alterations in BCAT1 activity to neurological disorders, few are well-studied in the context of the brain. The work described here combines both in …
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Cytoskeletal changes in SY5Y neuroblastoma cells exposed to acrylamide: an immunocytochemical study
The neuronal cytoskeleton is vital for normal growth and differentiation of the nervous system, as well as for maintenance of the normal intracellular environment. Without it, major functional deficits occur due to interference with cellular transport of membrane components, proteins and …
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… cofactors govern gene transcription in various developmental and tissue contexts, particularly during cardiovascular and neuronal development. This dissertation aims at studying the in vivo relevance of the partnership between Serum response Factor (SRF) and its Myocardin Related Transcription …
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Neuronal Laterality in Caenorhabditis elegans: Morphological and Functional Aspects
… of C. elegans are an excellent model to study neuronal asymmetry. Lateralization with respect to their genetic fate and function has been well studied, but their more subtle asymmetries have not. This work describes three such asymmetries: that of amino acid gustation, associative learning, and …
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Using light to control and investigate cell biology
… light plays an important role in life. With the development of modern technologies, light has also proven to be a powerful tool for the interrogation of molecular and cellular biology. Beyond its use in microscopic applications, light has emerged as an attractive modulator of cellular function. …
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Modelling Prenatal Hypoxia As A Risk Factor For Schizophrenia Vulnerability In Patient-Derived Cerebral Organoids
Prenatal hypoxia during fetal development is a significant environmental risk factor linked to schizophrenia (SCZ) vulnerability. However, hypoxia’s impact on human brain development at the cellular level remains unclear. Our laboratory has developed human cerebral organoids using induced …
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Neuroprotectant Properties of Neurosteroids During Neonatal Ethanol Exposure
… ethanol exposure significantly affected development of medial prefrontal cortex pyramidal neurons by decreasing apical dendritic length and intersections. Neurosteroid treatment affected neuronal measurements in a sex-dependent manner, with neurosteroids having minimal to no effect on …
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