Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 77 for “"Neuronal death"”.
-
Neuroprotection of AG490 in Oxidative Stress-induced Neuronal Death
… free radicals, which has an important role in neuronal death. Free radicals oxidize intracellular molecules, the destabilization of membrane integrity, and the mitochondrial dysfunction. In present study, we investigated whether AG490, a specific Janus kinases 2 (JAK2) inhibitor had an effect …
-
Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
… family is essential for ER stress-induced cell death. PUMA is known to be a key transcriptional target of p53, however we have found that ER stress triggers PUMA induction and cell death through a p53-independent mechanism involving instead the ER stress inducible transcription factor ATF4. …
-
Neuroprotective Effects of Anthocyanins on Neuronal Death Induced by Inhibition of Bcl-2 and Oxidative Stress
… mitochondrial oxidative stress (MOS) leading to neuronal death. Here, we investigated the neuroprotective effects of a novel class of nutraceuticals, anthocyanins, against MOS-induced death in primary cultures of rat cerebellar granule neurons (CGNs). Anthocyanins are natural antioxidants whose …
-
Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… response including dopaminergic (DA) neuronal degeneration, microglia activation, inflammatory mediator expression and infiltration of peripheral immune cells in the SN. Additionally, we surveyed whether CAP would have ability to DA neuronal protection against LPS and how CAP regulates …
-
Neuronal Toxicity of Humoral Factors From Patients With Diabetic Neuropathy and Mechanism of Neuronal Death on Cultured Adrenergic Neurons: Studies of Autoimmune Pathogenesis in Diabetic Neuropathy
… 1993; 1995). Some sera were cytotoxic and caused neuronal death. Further characterization of the inhibiting, or toxic, factor in IDDM patient serum indicated that it had the properties of an immunoglobulin. The toxic factor was present in the immunoglobulin fraction, and was pre-absorbed by …
-
Glutamate Excitotoxicty Activates a Novel Calcium Permeable Ion Channel in Cultured Hippocampal Neurons
… is the predominant mechanism implicated in neuronal cell death associated with neurological disorders such as stroke, epilepsy, traumatic brain injury and ALS. Excessive stimulation of NMDA subtypes of glutamate receptors leads to protracted intracellular calcium elevations triggering …
-
NADPH oxidase in PC12 cell differentiation and apoptosis
<p>Neuronal differentiation is an important process during human development and regenerative medicine. One factor linked to differentiation of neurons <em>in vivo</em> as well as <em>in vitro</em> is the generation of reactive oxygen species (ROS). In addition, neurodegeneration is the disease of …
-
Novel Roles for the Tissue Plasminogen Activator System in the Development of Fetal Alcohol Syndrome and the Regulation of Contextual Learning After Stress
… tPA<sup>-/-</sup> mice were protected from neuronal death, suggesting tPA mediates ethanol-induced neurodegeneration and FAS in mice. Commensurate with neuronal death, we observed ethanol-induced cognitive impairments in adult WT, but not tPA<sup>-/-</sup> mice. To understand how ethanol …
-
Excitotoxicity, oxidative stress and neuroprotection in cerebellar granule neurones
Neuronal death due to excitotoxicity and oxidative stress is a critical part of several major disease processes, including ischaemic brain damage and Alzheimer’s disease. This study used cultures of cerebellar granule neurones as a model for investigation of these processes, considering both their …
-
The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… long been established as a key contributor to neuronal death. Also contributing to ischemic/reperfusion-induced neuronal death is oxidative stress, chemically defined as a pathologic state within the cell arising from the increased generation of reactive oxygen and nitrogen species and/or a …
-
The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… long been established as a key contributor to neuronal death. Also contributing to ischemic/reperfusion-induced neuronal death is oxidative stress, chemically defined as a pathologic state within the cell arising from the increased generation of reactive oxygen and nitrogen species and/or a …
-
Misregulation of Iron Handling Proteins in Excitotoxic Brain Injury
… reactive oxygen species (ROS), which can cause neuronal death in neurodegenerative diseases. The present study was also carried out to elucidate the expression of iron handling proteins such as divalent metal transporter-1 (DMT1) isoforms, iron regulatory proteins (IRPs), and ferritin in the …
-
THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING
… and mGluR5 - are believed to contribute to neuronal death upon overstimulation and may be neuroprotective under other conditions. To develop treatment for mGluRs, we must identify proteins involved in their signalling. We have identified proline-rich tyrosine kinase 2 (Pyk2) as an mGluRl/5 …
-
Cell model of DJ-1-associated Parkinson’s Disease
… of motor function resulting from dopaminergic neuronal death in the substantia nigra pars compacta leading to subsequent decreased striatal dopamine levels. The majority of PD cases are diagnosed as sporadic in nature, however 10% - 15% of patients show a positive family history of the disease. …
-
Stacked generalization for early diagnosis of Alzheimer's disease
… disorder characterized by nerve degeneration and neuronal death. The diagnosis of AD at an early stage is a major concern due to growing number of elderly people affected by the disease, as well as the lack of a standard diagnosis procedure available to community clinics. A biomarker that will …
-
Characterisation of substance P and transient receptor potential melastatin channel messenger RNA and protein expression in acute and chronic neurological disorders.
… brain injury (TBI) is the leading cause of death and disability in people under 40 years of age, with motor vehicle incidents accounting for the majority of severe TBI cases. Despite the public health burden of TBI, there are no effective treatment options available, with survivors often …
-
Cell Death Mechanisms in Drosophila Differentiated Photoreceptor Neurons
<p>Apoptosis, or programmed cell death, is a form of physiological cell death that is essential for normal development and homeostasis. At the end of pupal development of the Drosophila retina, cell death terminates and photoreceptor neurons complete their differentiation process. We use these …
-
LRRK2 Regulates Actin Dynamics in ADP-Treated Microglia
… neurodegenerative disease caused by dopaminergic neuronal death in the substantia nigra. Microglia are brain macrophages that continuously survey the microenvironment of the brain to find out and repair brain damage. Although PD associated genes are expressed in microglia, their roles in these …
Page 1 of 4