Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 166 for “"Neuronal cells"”.
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Investigations on the Effects of Palmitate on Neuronal Cells
… podocytes, myocytes, and pancreatic islet cells. However, the effects of FAAs on neuronal cell function are not well characterized. In this study, mouse neuroblastoma cells from the Neuro-2a (N2a) cell line were treated with either bovine serum albumin (BSA) or different concentrations of …
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Effects of Aggregated Alpha-Synuclein on Cultured Neuronal Cells
… that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular mechanisms governing this cytotoxicity and spread are poorly characterized. Recent studies of viruses and bacteria, which achieve their cytoplasmic entry by …
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mRNA stability in soma and neurites of cultured neuronal cells
… of neural projections and soma of mouse neuronal cells following inhibition of transcription with actinomycin-D. Less stable transcripts were enriched for GU-rich elements in their 3' UTRs. Around 12% of alternative splicing isoform pairs differed in stability, and cassette alternative …
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Chemical Induced Hypoxia Differentially Affects Gene Expression in Human Neuronal Cells
… (a low oxygen condition) which decreased human neuronal cell viability, but some cells still survived. These surviving neurons showed no morphological changes when compared to the non-treated group. However, the alteration of several intracellular events were detected, such as an increase of …
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Characterization of peptide release from neuronal cells with microfluidics and mass spectrometry
… network of a large number of neurons, and the neuronal communication between these cells often relies on chemical signals. Deciphering these signaling molecules, including neuropeptides, is an important but challenging task. Microfluidic technology allows the manipulation of mass-limited …
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Development and application of correlative STED and AFM to investigate neuronal cells
… interest in understanding brain development and neuronal function. Migration is a complex interplay between cytoskeletal reorganisation and cell mechanical stiffness. In order to improve understanding of this process, correlative measurements of cytoskeletal organisation and mechanical stiffness …
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Identification and characterization of glial and neuronal cells in vitro and in bone marrow
… attempts to identify and characterize glial cells and neuronal cells in avian brain and mammalian bone marrow, respectively. The project has four major objectives: (a) to culture and maintain avian glial and neuronal cells up to 20 days, (b) to examine cell cultures using selective …
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In-vitro experiments on neuronal cells and computer modeling over realistic head models in TMS
… dissertation discusses the effects of TMS on neuronal cells in vitro and the computational simulations modelling the stimulations delivered to the head. A dopaminergic neuronal cell line is used to examine how TMS affects the proliferation of the cells in vitro. The effects of TMS promoting …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
… of neurotransmitter systems and contribute to neuronal cell death. This effect can explain the behavioural changes, drug dependence and neuro degeneration observed in steroid abuser. Nandrolone treatment (10-8M–10-5M) caused a time- and concentration-dependent downregulation of mu opioid …
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Novel polymer constructs for controlled release and presentation of topographic cues in support of neuronal cells
… to optimize neuron growth across scaffolding a neuronal scaffold designed with an electrically conductive polymer, polypyrrole (PPy), will be used as a substrate to enhance nerve cell interaction in vitro. The polymer will be analyzed for the capacity to influence cellular phenotype, including …
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The Effect of impaired Cyclooxygenase 2 activity on gene regulation in the developing mouse brain and the role of PGE2 in oxidative stress production in Differentiated Neuronal Cells
… gene expression and alter oxidative stress in neuronal cells. In study 1 we use microarray analysis to identify differentially expressed genes among males and females at embryonic day 16 (E16) and 19 (E19). Bioinformatics software outlined genes involved in mitochondrial function, inflammatory …
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Electrochemical Determination of Extracellular Phosphorylation in Neuronal and Neuroblastoma Cells
… profiles of human neuron and neuroblastoma cells through the use of surface-based electrochemical sensors. This investigation started by demonstrating electrochemistry as a simple and effective technique to determine the phosphorylation state of neuronal proteins. The nAChR α7 subunit, an …
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SF-1, BUT NOT DAX-1, PREVENTS P19 CELLS FROM DIFFERENTIATING TO EITHER TROMA-1 OR TUJ1 POSITIVE CELLS UPON RA-TREATMENT
… factors (PBX) mRNA and protein levels in P19 cells prevents them from differentiating to either endodermal or neuronal cells. This suggests that PBX is an important regulator of RA-induced differentiation of P19 cells. A microarray analysis was performed to identify PBX regulated genes, …
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Cerebrovascular and Neuronal Cellular Consequences of Amyloid-β Induced Nuclear Factor-κB Activation
… that a common element in cerebrovascular and neuronal cells mediates disease progression. With its significant role in inflammatory responses, the nuclear factor-κB (NF-κB) pathway is hypothesized to play such a regulatory function in AD.</p> <p>The work presented here examines the cellular …
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Neuroprotective Effects of Sulforaphane and the Involvement of Autophagy
… aims to investigate the bioactivities of SFN on neuronal cells. PC-12 and SH-SY5Y cells were used to resemble neuronal-like systems to research especially autophagy as well as nuclear factor E2-related factor 2 (Nrf2) and how these pathways might influence neuroprotective abilities of SFN. Basal …
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Characterization of the mechanisms behind the alternative splicing of the mutually exclusive exons 18N and 18A in the sodium channel gene SCN8A and mutually exclusive exons 5N and 5A in the soldium channel gene SCN9A
… of action potentials in electrically excitable cells. There are 10 distinct sodium channel isoforms Na<sub>v</sub> 1.1-1.8 (SCNIA-SCN5A and SCN8A-SCNIIA) and the majority of these undergo tissue and developmentally regulated alternative splicing. Two such examples are those of the SCN8A (Nav …
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MACROPHAGE RESPONSE TO INITIAL MUSCLE DENERVATION IN THE SOD1-G93A MOUSE MODEL OF AMYTROPHIC LATERAL SCLEROSIS.
… It is plausible that early alterations in the neuronal microenvironment could create MN vulnerability which may ultimately affect survival of the MN. Indeed while motor neurons are the primary targets in ALS, non-neuronal cells such as glial cells and immune/inflammatory cells are also known …
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The isolation, partial purification and preliminary characterization of a growth factor from chick embryo brains
… In this study, cultured chick embryo brain non-neuronal cells were employed in a bioassay to monitor CBGF activity throughout various stages of its pllrification. Cell culture and assay conditions were optimized. Nonneuronal cells grew best on collagen-coated culture dishes in complete medium, …
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