Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Neuronal apoptosis"”.
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… essential role for Rho GTPases as regulators of neuronal morphology and neuronal survival. In particular, Rac GTPase generally induces neurite outgrowth and promotes neuronal survival while Rho GTPase typically provokes neurite retraction and induces neuronal apoptosis. However, the precise …
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Molecular regulation of neuronal apoptosis in PC12 cells.
In this study apoptosis was induced in neuronal PC12 cells by 2-5 $\mu$M VM26 (teniposide, a known apoptotic inducer) and changes in the expression of genes considered to be involved in apoptosis were examined by RT-PCR. Cell death, DNA fragmentation and morphological changes associated with …
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Determining the Role of Trib3 in Neuronal Apoptosis
Naturally occurring apoptosis in the developing nervous system is an important event for the proper shaping of the system, for eliminating precursor cells with mutations and for curbing the population of post-mitotic neurons so that appropriate target innervation can take place. In the latter case, …
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Rutas de señalización intracelular que regulan la apoptosis inducida por lovastatina en neuroblastos fetales de rata
… signals and molecular mechanisms that control neuronal apoptosis. We have mainly focused our attention to the survival pathways Duch as RAS/RAF/MAP-kinases, PI3-K/PKB, as well as death pathways, stress-activated MAP-kinases (JUN-kinases and p38).
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The Role of Wnt3a in Ischemic Stroke
<p>After ischemic stroke, apoptosis of neurons is a primary factor in determining outcome. Wnt3a is a naturally occurring protein that has been shown to have protective effects in the brain for traumatic brain injury. Although wnt3a has been investigated in the phenomena of neurogenesis, …
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Regulations and functions of P2Y₂ and P2X₇ nucleotide receptors in the central nervous system
… It is stored in synaptic vesicles, released upon neuronal excitation, and activates both ion channel receptors (P2X) and G protein-coupled receptors (P2Y) on post-synaptic cells. In addition to its role as a neurotransmitter, ATP and other nucleotides are known to be released from injured or …
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Cellular and Circuit Level Responses to Neural Stem Cell Transplantation in the Rodent Cortex
… marked depletion in host neurons and associated neuronal metabolites. Microglial activation preceded neuronal loss in the transplanted brain and deactivation with doxycycline exerted a neuroprotective effect. Analysis of C17.2-conditioned supernatants showed they secrete a number of …
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The role of neuron-microglial interactions in Ataxia-Telangiectasia
… interactions between neurons and non-neuronal cell types, such as the resident macrophages of the central nervous system called microglia, may underlie the neurological deficits observed in A-T. The loss of ATM has been shown to drive cell-intrinsic microglial dysfunction, however, it …
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EXERCISE-INDUCED ORGAN PROTECTION IN A MURINE MODEL OF CARDIAC ARREST AND RESUSCITATION
… was evidenced by a lower fraction of hippocampal neuronal apoptosis compared with non-exercised animals and a concomitant preservation of retrograde memory.
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스트레스에 의한 Long-term potentiation (LTP)의 저하를 감소시키는 리튬의 효과
… in vivo and in vitro, including prevention of neuronal apoptosis and stress-induced structural remodeling. Enhancement of LTP by lithium treatment was reported by an in vitro study. On the other hand, some studies have reported the attenuation of effects of chronic stress situation. In this …
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Subtile dosisabhängige Aufmerksamkeitsstörungen im Bereich der Hintergrundbelastung mit Blei im Blut : Bewertung empirischer Studienergebnisse unter Berücksichtigung neuropsychologischer und biochemischer Wirkungsmechanismen von Blei
… light on the modulation of synaptic plasticitiy, neuronal apoptosis, neural degeneration and adult neurogenesis due to lead. There are few references to be found on the effects of lead below the HBM-I-value with respect to neurocognition in adults. It is for this reason that the Institute of …
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Role of Membrane Contact Sites in the Neuropathogenesis of GM1-Gangliosidosis
… overload, activation of the caspase cascade and neuronal apoptosis. Purpose. Given the similar functions between the MAM and ER-PM junctions in Ca2+ dynamics and lipid transport, we sought to determine if GM1 accumulation at the respective membranes of β-Gal KO neurons would facilitate the …
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Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
… of ATF4 sensitizes neurons to ER stress induced apoptosis, and that ATF4-deficient neurons exhibit markedly reduced levels of PUMA expression and cell death. However, chromatin immunoprecipitation experiments suggest that ATF4 does not directly regulate the PUMA promoter. Rather, we found that …
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Role of BCL-XL in cell death after spinal cord injury
… spinal cord injury (SCI) results from secondary apoptosis regulated in part, by SCI-induced decreases in protein levels of the anti-apoptotic protein Bcl-xL. In this dissertation, I assessed the role that Bcl-xL subcellular re-routing and post-translational phosphorylation play in SCI-induced …
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Infant populations exposed to prolonged sedation: are they at risk for long-term sequelae?
… opioid exposure is associated with increased neuronal apoptosis (neuronal cell death). In addition, human studies in premature children have suggested that prolonged opioid treatment is associated with decreased visual intelligence, social skills, and memory function. The goal of this study …
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Therapeutic Effects of Human Mesenchymal Stem Cells on Traumatic Brain Injury in Rats: Secretion of Neurotrophic Factors and Inhibition of Apoptosis
… mechanisms for functional recovery by reducing neuronal apoptosis.
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Discovery of a Novel Signaling Circuit Coordinating Drosophila Metabolic Status and Apoptosis
<p>Apoptosis is a conserved mode of cell death executed by a group of proteases named caspases, which collectively ensure tissue homeostasis in multicellular organisms by triggering a program of cellular "suicide" in response to developmental cues or cellular damage. </p><p>Accumulating evidence …
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Revelation of new properties of pro-apoptotic human proteins, Bax and α-synuclein, using baker's yeast
Apoptosis is a form of programmed cell death which is essential for growth of dividing human cells whereas, in contrast, it is deleterious for post-mitotic cells such as neurons. Bax and α-synuclein are two human proteins which play a role in the induction of neuronal apoptosis in neurodegenerative …
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Treatment of HIV associated neurocognitive disorders
… mediates inflammation signaling pathways and neuronal apoptosis. Lithium has been used in mood disorders and other neuropsychiatric conditions for more than 40 years. In addition, lithium is a low-cost drug and widely available in public service settings in low and middle-income countries. …
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