Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Neuronal Proteins"”.
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Phosphorylation sites on specific neuronal proteins can control the mode of synaptic vesicle exocytosis and thereby regulate synaptic transmission
Synaptic vesicles (SVs) can exocytose via Full fusion (FF) or by Kiss-and-Run (KR) mechanisms. In this thesis, synaptosomes prepared from adult rat cerebrocortex demonstrated that these modes can be switched by regulating the intracellular calcium levels and/or protein phosphorylation reactions. …
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A Novel Exo-Proteomic Approach to the Study of Traumatic Brain Injury
… there are challenges in proteomic analysis of neuronal proteins. Current methods, such as sampling cerebral spinal fluid via lumbar puncture, are both invasive and carry risk of injury. Discovery of trauma-specific biomarkers present in peripheral blood may present a viable alternative. …
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Electrochemical Determination of Extracellular Phosphorylation in Neuronal and Neuroblastoma Cells
… to determine the phosphorylation state of neuronal proteins. The nAChR α7 subunit, an abundant and essential surface receptor protein, was used as an example protein and three important ectokinases, PKA, PKC and Src, were utilized to phosphorylate the protein. To confirm these results, gel …
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The Role of Sulfatide in Alzheimer's Disease
… ST null mice, voltage gated sodium channels, neuronal proteins that normally cluster at the nodes of Ranvier, initially accumulate in the node but are not retained with age. Taken together the findings from the ST null mice indicate that membrane organization is compromised. Recently, a …
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Characterization of the Fast Axonally Transported Proteins in the Rat Optic Pathway
<p>The fast axonally transported proteins represent a subset of neuronal proteins that are conveyed anterogradely as secretory vesicle constituents from the perikarya. Although fast transport displays properties consistent with the general secretory pathway, neuronal structure presents special …
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Regulation of Polarized Protein Transport to Axons, Dendrites, and Sensory Cilia in Caeborhabditis Elegans Neurons
… between these domains are critical for neuronal function, and are a result of asymmetric trafficking of a large number of cellular components including ion channels, neurotransmitter receptors, synaptic vesicles, and signaling proteins. Yet, despite the significance of asymmetric protein …
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Actions of alpha-chimaerins in mechanisms relevant to dendritic spine formation and neurodegeneration
… exchange factors (GEFs) and GTPase activating proteins (GAPs) represent an important class of molecules controlling dendritic spine plasticity. Although they are typically described as cytoskeletal modulators, roles for the GTPases in endocytosis and cell polarity establishment have also been …
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Hedgehog - like Proteins are Involved in a Novel Glia - Neuron Signalling Pathway in C. elegans
… glia-neuron signalling pathway that regulates neuronal properties in very specific ways. Two key players in this mechanism are WRT-6, a Hedgehog-like protein secreted by the socket glia, and PTC-1, a Patched homolog found in the amphid neurons. It is believed that <em>C. elegans</em>, lacking …
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The Effect of Embryonic Alcohol Exposure on Brain Function and Behavior in Zebrafish Strains
… responses result in long-lasting changes in neuronal markers and number of cells in specific brain areas. I included results on multiple strains of zebrafish in some of my studies. Strain differences will facilitate the discovery of molecular mechanisms underlying changes in alcohol-related …