Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"Neuronal Protection"”.
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Neuronal Protection by a Novel C-terminal Hsp90 Modulator
… analyses demonstrated significant protection against dendritic pathology and neuronal death in KU-32-treated vs vehicle-treated rTg4510 mice. Further studies were conducted to examine the potential mechanisms of drug action. We hypothesized that KU-32 activated the heat shock …
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E2F6 in axial skeletal development and gliosis
… in response to neurodegeneration, ischemia, and neuronal cell death. This process provides neuronal protection by restricting inflammation and regulating the concentration of molecules in the extracellular environment.
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… response including dopaminergic (DA) neuronal degeneration, microglia activation, inflammatory mediator expression and infiltration of peripheral immune cells in the SN. Additionally, we surveyed whether CAP would have ability to DA neuronal protection against LPS and how CAP regulates …
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Experimental Modelling and Molecular Mechanisms of Wallerian Degeneration in Traumatic Axonal Injury
… and genetic modulators of WD. Using a primary neuronal stretch-injury system we demonstrate that rates of neurite degeneration are altered by modulators of the WD pathway but that a purported neuroprotective compound ‘P7C3-A20’ did not protect primary cultures in vivo and did not act via a WD …
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Uncovering Zn2+ and Ca2+ Homeostasis and Crosstalk in Primary Hippocampal Neurons
… primary hippocampal neurons. We established the neuronal protection roles of MT3 and Zn<sup>2+</sup> spikes during glutamate excitotoxicity, indicating that Zn<sup>2+</sup> is essential to maintain neuronal health during development of functional neuronal network, where large synchronous neuronal …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… largest immune compartment, as well as a vast neuronal network, the enteric nervous system (ENS). In concert with the commensal intestinal microbiota, the enteric immune and nervous systems communicate with one another, and this crosstalk was the focus of my thesis work. The studies as …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
… with HSV reactivation from neurons. However, neuronal signaling pathways cardinal to HSV latency and reactivation are still not clear. This dissertation provides new understanding of HSV latency and reactivation in response to two orthogonal stress stimuli, viz. stress hormones epinephrine …
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Mechanism of Action of Nicotinamide Phosphoribosyltransferase Mediated Signaling in Oxidative Stress
… that are caused by oxidative stress. Neuroprotection and protection of cells supporting the function of neurons could provide novel therapeutic approaches to treating and preventing neurodegenerative diseases when therapies do not exist or existing therapies fail (3). Nicotinamide …
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Regulation of Transglutaminase by 5-HT2A Receptor Signaling and Calmodulin
… transamidation of Rac1 and htt in cultured neuronal cells and HD transgenic animals, respectively.</p><p>5-HT2A receptors are G-protein coupled receptors which are widely expressed in the brain, peripheral vasculature, platelets and skeletal muscle. They are involved in diverse physiological …
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Effects of Estrogens on Astrocytes Exposed to Stressors
… correlations between estradiol and cellular protection, but recent research has concluded CEE provide less protective mechanisms as compared to endogenous hormones. This research sought to compare the effects of estrogen treatments (single and combined estrogen) on viability when astrocytes …
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Sympathy for the Microbiota: How Changes in Gut Microbial Composition Influence the Immune System and Basic Physiology by Way of the Sympathetic Nervous System
… polarization was dependent upon sympathetic neuronal activation in the celiac-superior mesenteric ganglion (CG-SMG), which enabled communication from the lumen to MM through adrenergic receptor beta 2 (ADBR2) engagement (Gabanyi & Muller et al., 2016). Together, these results established that …