Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Neuronal Nitric Oxide Synthase"”.
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Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment
… rates have continued to increase over the years. Neuronal nitric oxide synthase (nNOS) produces nitric oxide (NO) has been found to be overexpressed in human melanoma and the expression of nNOS is induced by interferon-gamma (IFN-γ). In our studies, nNOS has been implicated in IFN-γ-stimulated …
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Expression, inhibition and in silico modelling of human neuronal nitric oxide synthase
Nitric oxide (NO) is a free radical, gaseous molecule that is involved in a vast range of biological signalling processes including long term memory formation, neurogenesis, vasodilation and inflammation. The molecule is produced by a family of enzymes called nitric oxide synthases (NOS). There are …
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Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… fibers (PFs) that produce high levels of nitric oxide (NO) via neuronal nitric oxide synthase (nNOS). Previous studies demonstrate that nNOS/NO signaling is crucial for PF-PN synaptic transmission. This study sought to examine nNOS/NO signaling regulation of excitatory amino acid …
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Potential Prodrugs of the Neuronal Nitric Oxide Synthase and Monoamine Oxidase Inhibitor 7-Nitroindazole and Structurally Related Compounds
… nigrostriatal neurons. Two enzyme systems, the neuronal form of nitric oxide synthase (nNOS) and monoamine oxidase B (MAO-B), have been linked to neurodegenerative pathways leading to PD. Several MAO-B and nNOS inhibitors have been evaluated for their neuroprotective properties in the mouse …
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Regulation of skeletal muscle glucose uptake during contraction/ exercise by nitric oxide (NO)/ neuronal nitric oxide synthase MU (NOSμ)
… In humans, there is convincing evidence that nitric oxide (NO) plays a role in contraction-stimulated muscle glucose uptake and may be promising from a therapeutic standpoint for people with T2D since they have a greater reliance on NO-mediated glucose uptake during exercise. However, evidence …
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Genetically encodable calcium sensors for Magnetic Resonance Imaging
… the hemodynamic response, which is coupled to neuronal activity through a calcium-activated enzyme, neuronal nitric oxide synthase (nNOS). We show that chemical stimulation of ectopically expressed neuronal nitric oxide synthase (nNOS) elicits an artificial hemodynamic response detectable by …
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Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier
The neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) protects against the neurotoxicity of MPTP in a mouse model of neurodegeneration. Since 7-NI also inhibits the monoamine oxidase-B (MAO-B) catalyzed bioactivation of MPTP, the role of nNOS inhibition as a mediator of 7-NI's …
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Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex in skeletal muscle
… Dp116 did not restore the signaling molecule neuronal nitric oxide synthase (nNOS) to the DGC, and specific parts of the dystrophin rod domain not found in utrophin were shown to participate in localization of nNOS. However, association of nNOS with the DGC was not required for amelioration of …
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A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease
… NMDA receptor activation is linked with nitric oxide (NO) production and changes in synaptic plasticity, suggesting a role in dyskinesia. This led to the hypothesis that NO, produced by neuronal nitric oxide synthase (nNOS), contributes to the occurrence and evolution of dyskinesia in PD. …
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Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
… Our previous study suggests that neuronal nitric oxide synthase (nNOS)-mediated nitric oxide (NO) signaling is crucial for melanoma progression and forms a mechanistic rationale behind nNOS inhibition as a novel treatment strategy for CM. An additional study demonstrated that IFN-γ …
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A toxicological analysis of the cyanotoxin β-methylamino-L-alanine at multiple neural levels and identification of novel modes of activity
… disruption to mitochondrial activity and general neuronal death, indicate that the main mode of activity is via excitotoxic mechanisms. Data presented here indicate that BMAA induces increased intracellular Ca2+ influx, DNA damage, mitochondrial activity, lactate dehydrogenase (LDH) release and …
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A biochemical and molecular analysis of functional differences between dystrophin and utrophin
… was previously shown that utrophin cannot bind neuronal nitric oxide synthase (nNOS) even though dystrophin binds nNOS, establishing for the first time a functional difference between dystrophin and utrophin. Here, we show that transgenic overexpression of utrophin on the mdx mouse background …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… (NMDARs). Stimulation of NMDARs recruits neuronal nitric oxide synthase (nNOS) to the synaptic scaffolding protein, postsynaptic density protein 95 (PSD95), to produce nitric oxide (NO). Our laboratory has previously shown that disruption of the PSD95-nNOS interaction attenuates fear …
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Il Δ9-THC, componente principale della cannabis sativa, attenua la neurotossicità indotta dalla meth
… and adverse consequences like activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrite, microglia stimulation, astrogliosis and hyperthermia [Maxwell JC and Brecht ML, 2011]. Notably, METH abusers also consume Cannabis [UNODC, 2013]. Several line of research have …
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Triggering Nox2 / ROS Signaling During Disuse-Induced Skeletal Muscle Atrophy
Prolonged periods of reduced mechanical loading lead to physiological changes such as a reduction in muscle mass and strength. These morphological and functional changes are allowed to take place to regulate muscle mass, metabolic demand, and availability of the amino acid pool. Dysregulation of a …
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The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… ascorbate free radical [A<sup>•−</sup>] and nitric oxide [NO] metabolites via electron paramagnetic resonance spectroscopy and ozone-based chemiluminescence, respectively) and structural integrity of the NVU (<i>Study 1:</i> S100<i>ß</i> and neuron-specific enolase [NSE]; <i>Study 2 only: …
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Development of Pharmaceutical Inhibitors Targeting nNOS for Melanoma Treatment
… study was to determine whether nNOS-mediated nitric oxide (NO) signaling interacts with the COX-2-PGE2-PD-L1 signaling axis in melanoma. Our overall hypothesis is that in combination with COX-2 inhibitors, nNOS inhibitors may synergistically reduce melanoma tumor growth and extend mouse …