Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Neuronal Maturation"”.
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Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons
Neuronal maturation is an intricate and tightly-controlled process in neurodevelopment, during which neuronal cells acquire their mature molecular, morphological and electrophysiological properties to function as the central components of the nervous system. However, the cell-intrinsic mechanisms …
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THE INTERPLAY BETWEEN HPCAL4 AND MECP2: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PUTATIVE TARGET FOR RETT SYNDROME THERAPY
… abundant in brain and important for proper neuronal maturation and function. In fact, MeCP2 deficiency in neurons is responsible for impairment of fundamental aspects of neuronal development and function including defects in dendritic arborization and spine density. Besides Mecp2, several …
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Postmitotic Dynamics in Chromatin Modification and Regulatory Topology Underlie Cerebellar Granule Maturation
… Their birth is followed by their iterative maturation into functional neurons that can participate in CNS circuitry. This involves the temporally regulated programs of gene transcription enabling them to migrate, generate axons, dendrites, synapses, and spatial connections with other cells …
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Modelling Huntington’s Disease Using Direct Cell Reprogramming
… lines, involving hypoxic culture, BrainPhysTM neuronal medium, and the refinement of a multi-step striatal differentiation protocol. HD iNPs and MSNs were generated from HD HDFs using this refined protocol, and HD neurons exhibited significant alterations in neuronal morphology and …
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The Functional Role for Chromatin Loops in Gene Expression Control During Human Neuron Maturation
… stem cell (iPSC)-derived post-mitotic neuronal maturation. We find thousands of ablated and hundreds of ectopically formed loops upon auxin treatment in post-mitotic neurons. By contrast to previous reports in dividing cell lines, disruption of CTCF-mediated enhancer-promoter and …
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Developmental origins of cortical circuit dysfunction in a 22q11 deletion mouse model
… of progenitor proliferation, neurogenesis, and neuronal maturation. Disruptions in these processes contribute to the cortical circuit pathology observed in neurodevelopmental disorders such as schizophrenia and autism, intellectual disability. The 22q11.2 deletion syndrome (22q11DS) is a major …
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Chromatin accessibility informs cell identity: studies in silico, in vitro, and in vivo
… expression changes during mouse motor neuron maturation in vivo. Using a time-series of RNA-seq and ATAC-seq collected from embryonic, juvenile, and adult stages of mouse motor neuron development, we find that chromatin accessibility and gene expression changes become static as mice reach …
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THE EVOLUTION OF THE MODERN CONDITION THROUGH THE LENS OF NEURODEVELOPMENT DIVERSITY: INSIGHTS FROM A PARADIGMATIC REWIRING OF GENE REGULATION
… variant contributed to the modern pace of neuronal maturation. Through this framework we also exposed a fine-tuning of the oxygen-tension response mediated by a human-derived HFV associated to the CADPS2 gene and predicted to alter HIF1A binding. These findings implicate a modulation of the …
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Human induced pluripotent stem cell models of Rett Syndrome reveal deficits in early cortical development
… We generated a variety of monolayer and 3D neuronal models and found that RTT phenotypes are present at the earliest stages of brain development including neuroepithelial expansion, neural progenitor migration and differentiation, and later stages of membrane and synaptic physiological …
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Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro
… exposure to phenobarbital and carbamazepine on neuronal maturation of iPS-derived neurons was investigated. Exposure to both AEDs resulted in diminished membrane potentials and reduced the proportion of cells that were able to fire action potentials spontaneously in culture. The data from these …
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Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons
… neurons (ORNs), and is up-regulated with neuronal maturation. In the MeCP2 null OE there is a transient delay in ORN maturation and an increase in neurons of an intermediate developmental stage. Two protein variants of MBD2 are expressed in the OE, with MBD2b expressed in cycling …
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Mechanism of CASK-linked ophthalmological disorders
… CASK heterozygous knockout (CASK(+/-)), CASK neuronal knockout (CASKNKO) and tamoxifen inducible CASK knockout (CASKiKO) mouse models to investigate the mechanism and pathology of CASK-linked ONH. Our observations indicate that ONH occurs with 100% penetrance in CASK(+/-) mice, which also …
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
… These analyses revealed disruptions in neuronal maturation and migration processes from day 25 to 250 of differentiation. We observed temporally regulated gene expression defects and asynchronous cell type emergence in WVS, particularly affecting indirect neurogenesis. By identifying …
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The role of <em>Pax7</em> in the formation of the superior colliculus and the vertebrate visual system
… has explored the role of Pax7 in formation and maturation of the mouse superior colliculus, an important brain region associated with topographic visual input and the capacity to evoke appropriate visuomotor responses to environmental stimuli. The research performed was explicitly targeted at …
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Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
… the migration, differentiation and functional maturation of SVZ derived progenitors in models of cortical injury. We first characterized the temporal dynamics of electrophysiological maturation of layer V pyramidal neurons during postnatal development, establishing a baseline to interpret …
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Identification and characterisation of non-coding RNAs involved in ductal carcinoma in situ
… (GSEA), pathways related to the cell cycle and neuronal maturation were prominent. Overall, MEG3 appears to be tumour suppressive in DCIS and could be a marker of indolent disease. By discovering these ncRNAs found in abundance in high-grade DCIS, but not in normal-like or invasive breast cancer …
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Investigating the Impact of Sleep on Early Dynamic Functional Connectivity: A High-Density Diffuse Optical Tomography Study in Term and Preterm Neonates
… (McCann et al., 2018). The impact of sleep on neuronal maturation is especially critical for preterm neonates who experience environmental sleep disruptions early in development. Preterm birth has been associated with cognitive, social, and sleep difficulties later in life, outcomes that may be …
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The Effects of Neuropathy-Inducing Organophasphate Esters om Chick Dorsal Root Gangli Cell Cultures
Cultures of dorsal root ganglia (DRG) can achieve neuronal maturation with axons, making them useful for neurobiological studies. They have not, however, previously been used to investigate subcellular events that occur following exposure to neuropathy-inducing organophosphorus (OP) esters. Recent …
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Examining Hippocampal Reelin Expression and Neural Plasticity in an Animal Model of Depression
… decreased hippocampal neurogenesis, slowed cell maturation, and decreased cell complexity. Although we already know that these neurobiological changes are associated with significant impairments in important psychological functions such as learning, memory and motivation, we know little about the …
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A Developmental Pathway for Epithelial-to-Motoneuron Transformation in C. Elegans
… from the epithelium, cell migration, and neuronal maturation. A similar sequence of events characterizes formation of pancreatic insulin-secreting β-cells, which are innervated and express genes also active in motoneurons. Here, epithelial progenitor cells lining pancreatic ducts express …
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