Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 99 for “"Neuronal Differentiation"”.
-
The growth-arrest-specific protein gas7 potentiates neuronal differentiation
… gas7 protein is involved in neuronal development. Its role in neuronal differentiation and its potential neuroprotective activity were investigated in PC 12 and NT2 cells. gas7 overexpression in PC12 cells promoted neurite outgrowth and potentiated nerve growth factor-induced …
-
Transcriptional Regulation of Neuronal Differentiation in the Drosophila Central Nervous System
… thesis research has focused on the generation of neuronal diversity: specifically how neurons adopt individual, often unique, identities. Work in many labs has revealed that a large set of transcription factors act in combinatorial manner to specify the fate of individual neurons or small groups …
-
VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
… together with morphological alterations of motoneuronal phenotype. In this scenario, we decided to deeper investigate the role of VGSCs in neurite elongation, by taking advantage of the NSC34 cell line, an in vitro model often used in the study of motoneuron disease. Thus, we used two different …
-
Regulation of neuronal differentiation by activity-induced calcium influx in striatal neural precursors
Neuronal activity induces Ca2+ influx that regulates neurogenesis and distinct aspects of neuronal differentiation in the embryonic and adult brain. This thesis focusses on the regulation of neuronal differentiation in striatal neural precursors (NPCs) by activity induced Ca2+ influx. Neurons …
-
Neuronal Differentiation and Functional Recovery after Transplantation of Human Mesenchymal Stem Cell in The Ischemic Rat Model
… - glial fibrillary acidic protein(GFAP) and neuronal marker - neuronal nuclear antigen(NeuN). These findings show that some cytokine-inducted human mesenchymal stem cells were differentiated into neurons and astrocytes to replace the damaged neural cells in the rats of cerebral stroke. The …
-
The Role of Pax3 in Neuronal Differentiation of the Ophthalmic (OpV) Trigeminal Placode and Neural Tube during Chicken Embryonic Development
… Using several markers of placode cell differentiation, we have determined the experimental effects manipulating Pax3. Blocking placodal Pax3 with gene specific morpholinos resulted in a loss of migratory placode cells, and a downregulation of all opV placode markers in targeted cells. …
-
DIFFERENTIATION OF NEURAL STEM CELL USING SMALL MOLECULES IN 2D AND 3D CULTURE SYSTEM
The neuronal differentiation of neural stem cells (NSCs) has received much attention due to its potential for the treatment of neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). In this regard, discovering compounds that direct differentiation of NSCs is highly required to …
-
In vitro investigation of the molecular relationship between mitochondrial dysfunction and neurogenesis in autism aetiology
… between mitochondrial dysfunction and neuronal differentiation as it pertains to ASD aetiology. A key differentially methylated gene was Propionyl-CoA Carboxylase Subunit B (PCCB), a mitochondrial enzyme involved in metabolizing short fatty acids like propionic acid (PPA). Disruption of …
-
Transcriptional and Post-Translational Mechanisms Contribute to Maintenance of Rest In Neural Tumors
… system development. It negatively regulates neuronal lineage specification in neural progenitors by binding to its consensus <em>RE-1</em> element(s) located in the regulatory region of its target neuronal differentiation genes. The developmentally coordinated down-regulation of REST mRNA and …
-
Role of ASCL1 and Its Interactors in Neuroblastoma
Neuroblastoma (NB) arises due to incomplete differentiation of sympathoadrenal cells during development, and is maintained by either an adrenergic or mesenchymal core transcriptional regulatory circuitry (CRC). Differentiation therapies are an attractive therapeutic approach for NB. However, it is …
-
Study of Rest As A Negative Regulator of P16Ink4A
… Factor (REST) is a negative regulator of neuronal differentiation. It is expressed ubiquitously in early embryos, but downregulated in neural progenitors concomitant with onset of neuronal differentiation in these cells. REST has been widely studied as a negative regulator of neuronal …
-
Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
… molecular mechanisms regulating the migration, differentiation and functional maturation of SVZ derived progenitors in models of cortical injury. We first characterized the temporal dynamics of electrophysiological maturation of layer V pyramidal neurons during postnatal development, …
-
Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
… axon outgrowth. To explore the roles of Shh in neuronal differentiation, we utilized embryonal carcinomal P19 cells as an in vitro model system. We overexpressed Shh in P19 cells and investigated it’s effects on proliferation and differentiation of P19 cells., P19/Shh, P19 cells overexpressing …
-
NADPH oxidase in PC12 cell differentiation and apoptosis
<p>Neuronal differentiation is an important process during human development and regenerative medicine. One factor linked to differentiation of neurons <em>in vivo</em> as well as <em>in vitro</em> is the generation of reactive oxygen species (ROS). In addition, neurodegeneration is the disease of …
-
Neuroglial differentiation and neo-innervation in extracellular matrix-based tissue engineered innervated smooth muscle sheets
… quality of life. Neural-crest derived enteric neuronal progenitor cells persist in the adult mammalian gut, and contribute to the plasticity observed in the adult enteric nervous system. Neural stem cell transplantation is an emerging therapeutic paradigm aimed at repopulating enteric ganglia …
-
The effect of the cyanobacterial toxin saxitoxin on neurodevelopment
… low dose extended exposure using two models of neuronal development. Further, we aimed to establish an assay which could be used to determine if any adverse neurodevelopmental effects recorded were due to direct STX toxicity. Firstly, using model neuronal cell lines it was shown that STX at or …
-
THE ROLE OF DMRT GENES DURING NEUROGENESIS IN THE ZEBRAFISH FOREBRAIN
… I show that dmrt5 is a critical regulator of neuronal differentiation in the fore- and midbrain and of particular importance for the development of the telencephalon, olfactory system and the neuro-endocrine system. In parallel, I was able to knock-out dmrt3 in zebrafish by introducing …
-
Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
… neural stem cell pool and for proper pacing of neuronal differentiation. NeuroD1, a bHLH transcription factor, is necessary for the terminal differentiation, maturation, and survival of newborn neurons. In addition, both factors are necessary for the neurogenic response to both physiological and …
Page 1 of 5