Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 190 for “"Neuronal Cell"”.
-
Monoamine oxidase in neuronal cell death
… (ROS) contribute to oxidative stress in the cell and can directly inhibit electron transport, cause damage to mitochondrial DNA and enhance cell death signalling. In this study the role of MAO in cell death was investigated in dopaminergic neuroblastoma (SH-SY5Y) cells, in three diverse …
-
Investigating Neuronal Cell Classes and their Role in Cognition
Classifying neurons into different cell classes is both an idea that has existed since the origins of neuroscience, and one that is essential to understanding the complex interactions of the brain. While there has been a substantial effort to categorize neurons morphologically, molecularly and …
-
Effects of oxidative stress and neuroprotection in apoptosis in neuronal cell models
The PC12 and SH-SY5Y cell models have been proposed as potentially realistic models to investigate neuronal cell toxicity. The effects of oxidative stress (OS) caused by both H2O2 and Aβ on both cell models were assessed by several methods. Cell toxicity was quantitated by measuring cell viability …
-
Influence of Extracellular Matrix Stiffness and Topography on Neuronal Cell Behavior and Neurite Outgrowth
… disease is on the promotion and growth of neuronal cells. In vitro research attempts to improve this by modifying the stiffness and topography of the extracellular matrix (ECM). However, the limitations of in vitro experiments make it difficult to control the individual factors influencing …
-
Involvement of the Sigma-1 Receptor in Neuronal Cell Death and Alzheimer's Disease
… are thought to be correlated with progressive neuronal cell death in AD. Aβ leads to increased endoplasmic reticulum (ER) stress, decreased autophagy, and increased apoptosis, all of which may be contributing to the neuronal cell death that is seen in AD. The Sig-1R is known to reduce ER …
-
The localization of UCH-L1(Ubiquitin C-terminaHydrolase-L1) in lipid rafts of neuronal cell
… movement, and is characterized by dopaminergic neuronal loss in the substantia nigra, midbrain. Symtoms of PD are resting tremor, rigidity, postural instability and slowness of movement. Lipid rafts enriched glycosylphosphatidylinositol (GPI)-anchored proteins, glycosphingolipid and …
-
Strategies for Neuroprotection Using Passive (Neurotrophin-Deprivation) and Active (Virotoxin Exposure) Models of Neuronal Cell Death
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and Immunology, 2004.
-
Deciphering the mechanism by which humanin binding to IGFBP3 inhibits neuronal cell death in alzheimer’s disease
… humanin (HN) counteracts this IGFBP3-induced cell death. Unfortunately, the natural synthesis of this peptide decreases with age coincident with the time that people are likely to develop AD. In addition, the precise mechanism of action of HN is currently unknown. We have synthesized residues …
-
Integrated computational and experimental analysis of non-neuronal cell molecular mechanisms contributing to Alzheimer's disease progression
… Increasingly, there has been focus on non-neuronal cells, mechanisms by which they affect neurotoxicity, and their varied roles in disease progression. In this thesis, we apply systems techniques towards ADrelevant omics datasets to generate new hypotheses regarding non-neuronal cell …
-
Evaluation of the toxicity of the brominated flame retardants, PBDE-47 and HBCD, in neuronal cell lines
… the modes of action of PBDE-47 and HBCD in two neuronal cell models namely mouse neuroblastoma (N2A) and neuroblastoma x spinal cord (NSC-19). <br/>It was established that PBDE-47 and HBCD reduce cell viability, increase lactate dehydrogenase (LDH) leakage and cause apoptosis as indicated by …
-
Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
… cytokine that has been identified in directing neuronal response to disease or injury. Results are conflicting as to the role of TNF in mediating neuronal injury. TNF can protect neurons from excitotoxic and metabolic injury but can also mediate neuronal toxicity. We hypothesize that cell state …
-
Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target.
… neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, the mPT is defined by a sudden increase in …
-
Investigation of the endoplsmic reticulum calcium stores for their potential roles in neuroprotection using the NG115-401L neuronal cell line model
… and Parkinson's diseases. We have used the neuronal cell line NG115-401L with unique calcium signaling characteristics to test the hypothesis that improving calcium loading into the endoplasmic reticulum (ER) to increase ER calcium levels acts as a possible neuroprotective response. We …
-
K+-Induced Smooth Muscle Calcium Sensitization Requires RhoA Kinase (ROK) Translocation to Caveolae Which Is Inhibited in Non-Neuronal Cell Memory
… smooth muscle contraction by elevating intracellular free calcium ([Ca<sup>2+</sup>]i<sub>)</sub>, while receptor stimulation activates an additional mechanism termed Ca<sup>2+</sup>- sensitization that can involve activation of ROK and PKC. However, recent studies support the hypothesis that …
-
Genetic studies on functional redundancy between profilin1 and profilin2 im mice and the role of the profilin ligand Mena in neuronal cell function and mouse behavior
… mice and the role of the profilin ligand Mena in neuronal cell function and mouse behavior Profilin1 and profilin2 are two actin-binding proteins. Biochemically, proflin1 and profilin2 are similar in respect to their interactions with actin, phosphatidylinositol-4,5-bisphosphate (PIP2), and …
-
An Interactive Natural Host Model System for a Swine Alphaherpesvirus: Aujeszky's Disease Virus Cell Interactions in Immortalized Porcine Olfactory Neuroblasts
… the comprehensive characterization of the novel cell line, we infected the OBGF400 cells with ADY and investigated the ensuing comprehensive gene expression profile in comparison to a non-neuronal cell line, again by utilizing the Affymetrix array chip. The conducted studies exerted a highly …
-
Development of P7C3-Class of Neuroprotective Molecules
… these neuropsychiatric conditions have in common neuronal cell death, for which there is currently no effective pharmacologic treatment. Here, I describe the development of the P7C3-series of neuroprotective compounds, which were originally discovered through an unbiased in-vivo screen for new …
Page 1 of 10