Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Neuron morphology"”.
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Generative probabilistic models of neuron morphology
… it is now possible to image large populations of neurons at single-cell resolution. This imaging capability promises to create a new field of neural circuit microanatomy. Three goals of such a field would be to trace multi-cell neural networks, to classify neurons into morphological cell types, …
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Converting a Neuron-Morphology Reconstruction System: Open-Science Design and Implementation
… Online Reconstruction and functional Imaging Of Neurons (ORION) system for neuron-morphology reconstruction from an interpreted language to a compiled language. The motivation of this conversion is to provide a tool that can be used by neuroscience researchers to analyze their own neuron data and …
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Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… emerges from the coordinated development of neurons and glia. To better understand the processes that enable nervous system development and function we have studied the sensory organs of Caenorhabditis elegans because their anatomy and function are well-characterized. Specifically, we have …
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Distribution and regulation of ion channels in neurons: Quantitative studies of global ion channel transport and homeostatic synaptic scaling
A healthy neuron must continually produce millions of proteins and distribute them to function-specific regions of the cell. Among these proteins are ion channels that modulate neuronal excitability, allowing neurons to fulfill their primary role of information transfer. Neurons are unique among …
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Functional Labeling of Individualized Post-Synaptic Neurons using Optogenetics and trans-Tango
Neural circuitry, or how neurons connect across brain regions to form functional units, is the fundamental basis of all brain processing and behavior. There are several neural circuit analysis tools available across different model organisms, but currently the field lacks a comprehensive method …
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Validating ngn-1 transcriptome targets in C. elegans
… required for fate specification of multiple neuron types and brain structures. Despite its importance in nervous system development and function, the immediate downstream targets of neurogenin are not well characterized. The nematode <em>Caenorhabditis elegans</em> contains a single …
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Investigating the assembly of axonal domains for saltatory conduction
… how the AIS is assembled in central neurons, little attention has been paid to the assembly and maintenance of the AIS-like domain, the Proximal Segment (PS), in peripheral Dorsal Root Ganglion (DRG) neurons. Neurofascin B (NfascB), a zebrafish cell adhesion molecule homologue of the …
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A system-theoretic approach to global and local regulation in neuron morphologies
Synaptic plasticity is a crucial neuronal mechanism for learning and memory. It allows synapses to change their strength over time. This dissertation focuses on a particular form of synaptic plasticity called synaptic scaling, a homeostatic mechanism that preserves relative synaptic strengths in an …
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Role of BDNF-TrkB Signaling in Cocaine Addiction
… that promote changes in protein expression and neuron morphology. Cocaine-induced increases in dopamine ultimately alter dopamine signaling in brain regions modulating reward and motivation, specifically the nucleus accumbens (NAc), and downstream proteins. One protein of particular interest is …
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Early Life Circadian Rhythm Disruptions Alters Brain and Behavior in Adulthood
Children typically sleep much more than adults, and sleep in infancy and childhood is thought to play an important role in brain and cognitive development. However, the problem with examining poor sleep in toddlers is that sleep quality is often confounded with other factors such as socioeconomic …
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An Exploration of Neural Heterogeneity and its Consequences on Network Dynamics and Neuromodulation
… distribution to cell types and patterns of neuron connectivity. This heterogeneity has been linked to stable, persistent behaviour, increased information transmission, and effective neural encoding. Importantly, although neural heterogeneity is often regarded as a static property and …
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Influenza infection induces neuroinflammation and impacts hippocampal structure and function
… can result in a central inflammatory response, neuronal damage, and long-term neurobehavioral effects. Therefore, the broad aim of this research was to determine if peripheral infection with live influenza virus elicits a neuroimmune response and impacts hippocampal structure and function. …